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Zubsolv dosage: A detailed guide

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Form and strengthsDosageFAQHow it’s takenCouponOverdoseAsk your doctor
Doctors prescribe Zubsolv sublingual tablet to treat opioid dependence. You take it by dissolving it under your tongue once per day.
Medically reviewed by Elizabeth Scheffel, PharmD
Updated on

This article describes Zubsolv sublingual tablet’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for Zubsolv sublingual tablet.

If you want to know more about Zubsolv sublingual tablet, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.

Zubsolv is a brand-name medication that comes as a tablet you place under your tongue. It’s available in a generic version as a combination of two medications called buprenorphine and naloxone. This article describes dosages of Zubsolv.

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Form and strengths of Zubsolv

Zubsolv sublingual tablet comes as follows:

  • Form: a tablet you dissolve under your tongue
  • Strengths:
    • Buprenorphine 0.7 milligrams (mg) with naloxone 0.18 mg
    • Buprenorphine 1.4 mg with naloxone 0.36 mg
    • Buprenorphine 2.9 mg with naloxone 0.71 mg
    • Buprenorphine 5.7 mg with naloxone 1.4 mg
    • Buprenorphine 8.6 mg with naloxone 2.1 mg
    • Buprenorphine 11.4 mg with naloxone 2.9 mg 

Dosage of Zubsolv

This article describes the recommended dosages for Zubsolv sublingual tablet. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of Zubsolv without your doctor’s recommendation.

Usual recommended dosages of Zubsolv in adults

The dosage of Zubsolv sublingual tablet is highly individualized. When dosing, your doctor will consider which type of opioid you’re dependent on, when your last dose was, and the level of your dependence.

To start Zubsolv sublingual tablet for those dependent on heroin or a short-acting opioid, there is a 2-day induction dosage:

  • Day 1:
    • Initial dose: 1.4 mg buprenorphine with 0.36 mg naloxone (1 tablet of Zubsolv 1.4mg/0.36mg)
      • Additional doses of 1 to 2 tablets of Zubsolv 1.4mg/0.36mg may be taken 1.5 to 2 hours apart.
    • Recommended maximum dosage: 5.7 mg buprenorphine with 1.4 mg naloxone on day 1
  • Day 2: A single daily dose of Zubsolv up to 11.4 mg/2.9 mg

You should be given the first dose of Zubsolv sublingual tablet at the first signs of moderate opioid withdrawal. This should be at least 6 hours after your last opioid dose.

The usual maintenance dosage ranges from 2.9 mg buprenorphine with 0.71 mg naloxone to 17.2 mg buprenorphine with 4.2 mg naloxone per day.

While there is no maximum recommended dosage, doses higher than Zubsolv 17.2 mg/4.2 mg per day were not shown to add any additional benefit.

Dosage adjustments for Zubsolv

Your doctor will prescribe a dosage of Zubsolv sublingual tablet based on several factors. These include:

  • the specific condition being treated and how severe it is
  • your age
  • other health conditions you may have

Missed dose of Zubsolv

If you miss a dose of Zubsolv sublingual tablet, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose of Zubsolv sublingual tablet.

For tips on how to plan your doses of Zubsolv sublingual tablet and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about Zubsolv sublingual tablet and its dosage.

How does the dosage of Zubsolv compare with the dosage of Suboxone?

Zubsolv sublingual tablet and Suboxone are both a combination of buprenorphine and naloxone. Both are tablets you dissolve under your tongue once per day. But your body absorbs them differently.

So they have different strengths. For example, Zubsolv 5.7 mg buprenorphine with 1.4 mg naloxone is the same as Suboxone 8 mg buprenorphine with 2 mg naloxone.

Speak with your doctor or pharmacist if you have questions about the dosages of Zubsolv sublingual tablet or Suboxone.

Is Zubsolv taken long term?

Yes, doctors will continue to prescribe Zubsolv sublingual tablet as long as it’s benefiting you. If you and your doctor determine that it’s safe and effective for your condition, you may take it long term.

If you have questions about how long you should take Zubsolv sublingual tablet, talk with your doctor.

Is there a risk of misuse, dependence, or withdrawal with Zubsolv?

Yes. Zubsolv sublingual tablet contains buprenorphine, which is a controlled substance. This means you can misuse or become dependent on Zubsolv like you can with other opioids.

You should not abruptly stop taking Zubsolv sublingual tablet. Your doctor will recommend how to slowly decrease your dose over time. This will prevent withdrawal symptoms from happening.

Speak with your doctor or pharmacist if you have concerns about the risk of misuse, dependence, and withdrawal with Zubsolv sublingual tablet.

How Zubsolv is taken

You’ll dissolve Zubsolv sublingual tablet under your tongue once per day.

Your doctor may advise that you take this medication around the same time each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

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Overdose of Zubsolv

It’s important that you do not take more Zubsolv sublingual tablet than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of Zubsolv overdose

Symptoms of an overdose can include:

What to do if you take too much Zubsolv

If you think you’ve taken too much Zubsolv sublingual tablet, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for Zubsolv sublingual tablet. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of Zubsolv sublingual tablet without your doctor’s recommendation. You should take Zubsolv sublingual tablet exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • How do I know if my dosage of Zubsolv is working for me?
  • To start Zubsolv, will I need to take my dosage under medical supervision, or can I take it at home?
  • Does my doctor need to change my dosage of Zubsolv if I’m taking other drugs with it?

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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