This article describes possible interactions with rosuvastatin oral tablet. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.
Other drugs and rosuvastatin
The drugs in the list below may interact with rosuvastatin oral tablet. This article doesn’t include all drugs that may interact with rosuvastatin.
Drug classes or drugs that may interact with rosuvastatin oral tablet include:
- certain antacids:
- drug examples: calcium carbonate/magnesium hydroxide (Rolaids, others) and aluminum hydroxide/magnesium hydroxide (Maalox, others)
- what might happen: can make rosuvastatin less effective
- certain antivirals:
- certain cancer drugs:
- drug examples: capmatinib (Tabrecta) and enasidenib (Idhifa)
- what might happen: may increase risk of side effects of rosuvastatin
- fibrates (drugs used to lower cholesterol):
- colchicine (Colcrys, others):
- cyclosporine (Sandimmune, others):
- what might happen: may increase risk of side effects of rosuvastatin
- febuxostat (Uloric):
- what might happen: may increase risk of side effects of rosuvastatin
- niacin (Niacor):
- what might happen: may increase risk of serious muscle problems as a side effect of rosuvastatin
- teriflunomide (Aubagio):
- what might happen: may increase risk of side effects of rosuvastatin
- warfarin (Jantoven):
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Health factors and rosuvastatin
Certain medical conditions or other health factors may increase the risk of interactions with rosuvastatin oral tablet. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking rosuvastatin, tell your doctor about your health history. They’ll talk with you about rosuvastatin warnings and determine whether the drug is right for you.
These health conditions or other factors might interact with rosuvastatin oral tablet:
* For details, see the “When to avoid rosuvastatin” section below.
Alcohol and rosuvastatin
Rosuvastatin has no known interactions with alcohol. But it may not be safe to consume large amounts of alcohol while taking rosuvastatin oral tablet. Doing so can increase your risk of liver damage as a side effect of rosuvastatin.
If you drink alcohol and have concerns about limiting it while taking rosuvastatin oral tablet, talk with your doctor.
Other interactions and rosuvastatin
Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether rosuvastatin oral tablet has these interactions.
The information below doesn’t include all other interactions possible with rosuvastatin.
Rosuvastatin and supplements
Before taking rosuvastatin oral tablet, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.
Rosuvastatin oral tablet may interact with red yeast rice supplements. Some people take these supplements to lower cholesterol and for other uses. Rosuvastatin and red yeast rice supplements work in similar ways. So taking them together may raise your risk of side effects from rosuvastatin and red yeast rice supplements. This includes an increased risk of serious muscle problems such as myopathy and rhabdomyolysis.
Because of this, ask your doctor or pharmacist before taking supplements with rosuvastatin oral tablet. These include red yeast rice and other supplements. They can tell you whether it’s safe to take them together.
Rosuvastatin interactions with herbs
Rosuvastatin oral tablet isn’t known to interact with any herbs. But this doesn’t mean interactions with herbs can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before taking any of these products while taking rosuvastatin oral tablet.
Rosuvastatin interactions with vitamins and minerals
Rosuvastatin oral tablet isn’t known to interact with any vitamins. But the drug may interact with mineral supplements such as magnesium and aluminum. Keep in mind that some multivitamins may contain these minerals.
Taking rosuvastatin with these mineral supplements may lead to low levels of rosuvastatin in your body. This could make rosuvastatin less effective than usual for treating your condition.
Because of this, your doctor may recommend taking rosuvastatin at least 2 hours after consuming magnesium or aluminum supplements. Talk with your doctor or pharmacist before taking any of these products during treatment with rosuvastatin.
Rosuvastatin and food
Rosuvastatin oral tablet isn’t known to interact with foods. But this doesn’t mean rosuvastatin interactions with foods can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist about what foods you should avoid while taking rosuvastatin oral tablet.
Rosuvastatin and vaccines
Rosuvastatin oral tablet isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before receiving any vaccines while taking rosuvastatin oral tablet.
Rosuvastatin and lab tests
Rosuvastatin oral tablet isn’t known to interact with lab tests. But this doesn’t mean interactions with lab tests can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before having any tests while taking rosuvastatin oral tablet.
Rosuvastatin and cannabis or CBD
Rosuvastatin oral tablet isn’t known to interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But this doesn’t mean interactions can’t happen or won’t be identified later.
As with any drug or supplement, tell your doctor before taking cannabis with rosuvastatin.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Questions about rosuvastatin and interactions
Here you’ll find answers to some common questions about rosuvastatin and possible interactions.
Are there rosuvastatin interactions with grapefruit?
Rosuvastatin does not have interactions with grapefruit or grapefruit juice, unlike other statin drugs. But taking other statin drugs with grapefruit products could increase your risk of side effects from statins.
If you have other questions about rosuvastatin and grapefruit or grapefruit juice, talk with your doctor or pharmacist.
Does rosuvastatin interact with other medications that lower cholesterol?
Yes, rosuvastatin has interactions with certain other cholesterol medications. Specifically, rosuvastatin can interact with the following medications:
If your doctor prescribes these drugs with rosuvastatin, they’ll watch you closely for muscle problems and other side effects. They may adjust your rosuvastatin dosage to help lower these risks.
To learn more about rosuvastatin and other cholesterol medications, talk with your doctor or pharmacist.
When to avoid rosuvastatin
Certain health conditions or other factors could increase some risks with rosuvastatin oral tablet. Because of this, doctors may not prescribe rosuvastatin in these cases. These health conditions or other factors are called contraindications.
Here’s a list of contraindications for rosuvastatin oral tablet:
- Certain liver problems. If you have certain liver problems, taking rosuvastatin oral tablet may worsen them. These problems include acute (sudden) liver failure and decompensated cirrhosis (severe scarring of the liver). Rosuvastatin may cause liver damage as a side effect, and that can worsen these liver problems.
- Past allergic reaction to rosuvastatin. If you’ve ever had an allergic reaction to rosuvastatin oral tablet, taking it again may cause another allergic reaction.
Before you start taking rosuvastatin, tell your doctor if anything listed above relates to you. They can recommend whether you should take rosuvastatin.
Preventing rosuvastatin interactions
You may be able to help avoid certain interactions with rosuvastatin oral tablet. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.
Things to consider include:
- Whether you drink alcohol or use cannabis.
- Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
- What to do if you’re prescribed a new drug while taking rosuvastatin oral tablet.
Taking rosuvastatin exactly as prescribed can also help prevent interactions.
What to ask your doctor
If you have questions about rosuvastatin and possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- What should I do if I think I’m having a drug interaction with rosuvastatin?
- How do interactions of rosuvastatin and other statin drugs compare?
- I’ve started taking a supplement or another medication during my treatment with rosuvastatin. Should I tell my doctor or pharmacist?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
