This article describes Premarin’s dosages and strengths and gives details on how to use it. You’ll also find information on cost savings and coupon options for Premarin. If you want to know more about Premarin, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.
Premarin is a brand-name medication that comes as an oral tablet, vaginal cream, and injection. It is not available in a generic version. This article describes dosages of Premarin.
Boxed warnings
This drug has boxed warnings about the risk of certain cancers and dementia. It also has a boxed warning about the risk of serious heart or blood vessel conditions, such as stroke and blood clots. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).
See the end of this article for more information about these warnings.
Forms and strengths of Premarin
Premarin comes in these forms and strengths:
| Form | How to use | Strengths |
| oral tablet | take by swallowing | • 0.3 milligrams (mg) • 0.45 mg • 0.625 mg • 0.9 mg • 1.25 mg |
| vaginal cream | insert into the vagina | • 0.625 mg per gram (g) |
| injection | injected into your vein or muscle by a healthcare professional | • 25 mg per vial |
Dosage of Premarin
This article describes the recommended dosages for Premarin. The drugmaker provides these dosages.
If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of Premarin without your doctor’s recommendation.
Usual recommended dosages of Premarin in adults
Usually, doctors start by prescribing a low dosage of Premarin. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of Premarin that gives the desired outcome.
Dosage of Premarin oral tablet
The following table outlines the recommended dosages of Premarin oral tablet in milligrams (mg).
| Purpose | Recommended dosage |
| treatment of menopausal symptoms | 0.3 mg once per day* |
| treatment of low estrogen levels caused by hypogonadism | 0.3–0.625 mg once per day† |
| treatment of low estrogen levels caused by ovarian failure or ovarian removal | 1.25 mg once per day† |
| palliative care for breast cancer | 10 mg three times per day for at least 3 months |
| palliative care for prostate cancer | 1.25–2.5 mg three times per day |
| prevention of osteoporosis | 0.3 mg once per day |
* Your doctor may prescribe Premarin oral tablet every day or in cycles. An example of a cycle is 0.3 mg once per day for 25 days, followed by no medication for 5 days.
† Your doctor will prescribe Premarin oral tablet in cycles.
Dosage of Premarin vaginal cream
The following table outlines the recommended dosages of Premarin vaginal cream in grams (g).
| Purpose | Recommended dosages |
| treatment of vaginal dryness and vaginal thinning | Insert 0.5 g once per day for 21 days, then insert no cream for 7 days. Repeat this cycle as prescribed. |
| treatment of painful intercourse due to menopause | Insert 0.5 g twice per week. |
Dosage of Premarin injection
The recommended dosage of Premarin injection is 25 milligrams (mg) as a single dose. This injection will be given to you by your doctor or a healthcare professional.
If needed, the dose may be repeated in 6–12 hours.
Dosage adjustments for Premarin
Your doctor will prescribe a dosage of Premarin based on several factors. These include:
- the specific condition being treated and how severe it is
- your age
- other health conditions you may have
Missed dose of Premarin
Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of Premarin. They may advise you to take the missed dose. Or they may advise you to skip it and take your next dose as scheduled.
For tips on how to plan your doses of Premarin and avoid missing a dose, read this article. You could also try:
- downloading a reminder app on your phone
- setting an alarm
- putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table
Frequently asked questions
Below are answers to some commonly asked questions about Premarin and its dosage.
What is the recommended highest dose and lowest dose of Premarin?
The recommended doses differ depending on the form of Premarin you’re prescribed. The following table contains the recommended highest dose and lowest dose of Premarin, based on the form in milligrams (mg).
| Form | Highest recommended dosage | Lowest recommended dosage |
| Premarin oral tablet | 10 mg three times per day | 0.3 mg once per day |
| Premarin vaginal cream | 0.5 g twice per week | 0.5 g once per day |
| Premarin injection | 25 mg as a single dose | 25 mg as a single dose |
Keep in mind the highest dose that’s recommended for you may vary based on the condition being managed. If you have questions about the right Premarin dosage for you, talk with your doctor.
Is Premarin taken long term?
Possibly. Doctors typically prescribe Premarin as a long-term treatment for:
- treating symptoms of menopause
- treating low estrogen levels
- preventing osteoporosis
It’s recommended for short-term use when prescribed for unusual uterine bleeding. Premarin can be used as short-term or long-term treatment in people with breast or prostate cancer.
If you have questions about how long you should use Premarin, talk with your doctor.
How Premarin is taken
You’ll swallow Premarin oral tablet one to three times per day, depending on what you’re taking it for. Your doctor may prescribe the drug to be taken every day or in cycles. You can take the drug with or without food.
Premarin vaginal cream should be inserted into the vagina using the applicator once per day or twice per week. Your doctor may prescribe the drug to be applied every day or in cycles.
Premarin injection is given by a doctor or another healthcare professional, who will inject a dose of Premarin into a vein or muscle.
Your doctor may advise that you take this medication around the same time each day. This helps keep a consistent amount of the drug in your body and makes it work more effectively.
The drugmaker hasn’t specified whether Premarin oral tablet can be cut, crushed, or dissolved. If it’s hard for you to swallow tablets, view this article. It provides suggestions on how to swallow medications that come in pill form.
Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.
Premarin coupon
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Note: Optum Perks coupons cannot be used with insurance copays or benefits.
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