Skip to main content
Medically Approved

Nucynta dosage: A detailed guide

twitter share buttonfacebook share buttonlinkedin share buttonemail article button
Forms and strengthsDosageFAQHow it's takenCouponOverdoseAsk your doctorBoxed warnings
Doctors prescribe Nucynta and Nucynta ER for severe pain. You take Nucynta by mouth once every 4–6 hours as needed for pain. You take Nucynta ER by mouth every 12 hours.
Medically reviewed by Beth Thomas, PharmD, RPh
Updated on

This article describes Nucynta’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for Nucynta.

Nucynta is a brand-name medication that comes as an oral tablet. Nucynta ER is a brand-name medication that comes as an extended-release oral tablet. “Extended release” means the drug is released into your body slowly over a long period of time. Neither Nucynta nor Nucynta ER is available in a generic version. This article describes dosages of Nucynta and Nucynta ER.

Boxed warnings

Nucynta and Nucynta ER have boxed warnings about the following risks. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). These risks are:

See the end of this article for more information about these warnings.

Need a diagnosis or prescription quickly? For certain health conditions, Optum Perks offers personalized on-demand care with no appointment required. For $25, answer a few questions online and receive a diagnosis and treatment plan from a board certified healthcare professional in 15 minutes or less. Get started here.

Forms and strengths of Nucynta

Nucynta and Nucynta ER come in these forms and strengths described in milligrams (mg):

FormHow to takeStrengths
oral tablettake by swallowing• 50 mg
• 75 mg
• 100 mg
extended-release oral tablettake by swallowing• 50 mg
• 100 mg
• 150 mg
• 200 mg
• 250 mg

Dosage of Nucynta

This article describes the recommended dosages for Nucynta and Nucynta ER. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of Nucynta or Nucynta ER without your doctor’s recommendation.

Usual recommended dosages of Nucynta in adults

Usually, doctors start by prescribing a low dosage of Nucynta or Nucynta ER. Then they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of Nucynta or Nucynta ER that gives the desired outcome. Your doctor will also prescribe the drug for the shortest duration needed for your condition.

Below is the recommended dosage for Nucynta.

PurposeStarting dosageMaximum dosage
short-term, severe pain50–100 mg every 4–6 hours as needed for pain*600 mg total per day*

* On day 1, the second dose may be given as soon as 1 hour after the first dose if the first dose does not provide adequate pain relief. The maximum dosage allowed on day 1 is 700 mg total.

Below is the recommended dosage for Nucynta ER.

PurposeUsual starting dosageUsual maintenance dosageMaximum dosage
severe, persistent pain or severe, persistent pain due to diabetic neuropathy50 mg twice per day, approximately every 12 hours100–250 mg twice per day500 mg total per day

Dosages of Nucynta in children

Nucynta oral tablet is approved to treat short-term, severe pain in children ages 6 years and older who weigh at least 40 kilograms (kg) and are able to swallow tablets. One kilogram is about 2.2 pounds.

Nucynta ER is not approved for use in children.

Usually, doctors start by prescribing a low dosage of Nucynta. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your child’s doctor will prescribe the smallest dosage of Nucynta that gives the desired outcome. Your child’s doctor will also prescribe the drug for the shortest duration needed for their condition. In children, the prescribing information states that treatment should not last longer than 3 days.

Body weightStarting dosageMaximum dosage
40–59 kg50 mg once every 4 hoursmaximum single dose: 50 mg

maximum daily dose: 7.5 mg/kg/day, and no more than 600 mg total per day
60–79 kg50 mg once every 4 hoursmaximum single dose: 75 mg

maximum daily dose: 7.5 mg/kg/day, and no more than 600 mg total per day
at least 80 kg50 mg once every 4 hoursmaximum single dose: 100 mg

maximum daily dose: 7.5 mg/kg/day, and no more than 600 mg total per day

Dosage adjustments for Nucynta

Your doctor will prescribe a dosage of Nucynta or Nucynta ER based on several factors. These include:

  • the specific condition being treated and how severe it is
  • your age
  • how well your liver works
  • other health conditions you may have
  • whether you have taken an opioid pain reliever in the past
  • whether you have any risks for misuse and addiction

Missed dose of Nucynta

Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of Nucynta ER. They will likely advise you to skip the missed dose and take your next dose as scheduled.

For tips on how to plan your doses of Nucynta ER and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about Nucynta and its dosage.

How does the dosage of Nucynta compare with the dosage of oxycodone or tramadol?

It depends. Nucynta is an opioid pain reliever. Oxycodone or tramadol are also opioid pain relievers. The dosage of any opioid must be tailored to each person.

Like Nucynta, both oxycodone and tramadol come as an immediate-release oral tablet and an extended-release oral tablet. The immediate-release oral tablets release the drug into the body right away after you take a dose. The extended-release oral tablets release the drug into the body slowly over time.

There are some similarities with dosages of these drugs. The following are examples.

  • The immediate-release oral tablets of Nucynta, oxycodone, and tramadol, are taken by mouth every 4–6 hours as needed for pain.
  • The extended-release oral tablets of Nucynta ER or oxycodone are taken by mouth every 12 hours. The extended-release oral tablets of tramadol are taken by mouth once per day.

That said, the dosages of these medications differ in some ways. For instance, the tablets come in different strengths and may be used in different age groups.

For more details about how the dosage of Nucynta compares with the dosages of oxycodone or tramadol, see our articles about oxycodone oral tablet or tramadol oral tablet.

Is Nucynta taken long term?

Yes, it can be. It depends partly on whether you’re prescribed Nucynta or Nucynta ER.

Doctors don’t typically prescribe Nucynta oral tablet as a long-term treatment. Instead, it’s usually recommended for the shortest duration needed for your condition. Many conditions that cause short-term pain require no more than a few days of an opioid pain reliever, such as Nucynta. In children, treatment with Nucynta should not last longer than 3 days.

On the other hand, doctors typically prescribe Nucynta ER as a long-term treatment. It’s not approved to be used as needed for pain. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term. But it’s still important for Nucynta ER to be prescribed for the shortest duration of time needed to meet your treatment goals.

The dosage and duration of any opioid must be tailored to each person. If you have questions about how long you should take Nucynta or Nucynta ER, talk with your doctor.

How Nucynta is taken

You’ll swallow Nucynta oral tablet by mouth once every 4–6 hours as needed for pain. It can be taken with or without food.

You’ll swallow Nucynta ER by mouth twice per day, approximately every 12 hours. It can be taken with or without food. You should swallow the tablets whole. Take one tablet at a time, with enough water to ensure you can completely swallow it right after putting it in your mouth. Do not cut, chew, crush, or dissolve the tablets. Doing so can increase the risk of an overdose that could be fatal.

Your doctor may advise that you take Nucynta or Nucynta ER around the same time each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

With Nucynta or Nucynta ER, take the drug exactly as your doctor prescribed. Do not adjust the dose without talking with your doctor first.

If it’s hard for you to swallow tablets, view this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

Nucynta coupon

Visit these pages to access Optum Perks coupons and get price estimates for Nucynta and Nucynta ER when you use the coupons. These coupons can provide significant savings on your prescription costs.

Note: Optum Perks coupons cannot be used with insurance copays or benefits.

Download the free Optum Perks Discount Card to save up to 80% on some prescription medications.

Pill bottle with text 'Starts at $4'

Free prescription coupons

Seriously … free. Explore prices that beat the competition 70% of the time.

Get free card

Overdose of Nucynta

It’s important that you do not take more Nucynta (oral tablet or extended-release oral tablet) than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of Nucynta overdose

Symptoms of an overdose can include:

What to do if you take too much Nucynta

If you think you’ve taken too much Nucynta, call your doctor or pharmacist right away. Or you can call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for Nucynta (oral tablet or extended-release oral tablet). If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of Nucynta without your doctor’s recommendation. You should take Nucynta exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • Will my dosage of Nucynta be the same throughout my treatment?
  • How long will I be prescribed Nucynta?
  • Will you need to change my dosage of Nucynta if I’m taking other drugs with it?
  • Would a different dosage of Nucynta raise or lower my risk of side effects from the drug?
  • Should I take Nucynta with food?

Boxed warnings for Nucynta

This drug has boxed warnings about the following risks. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

Risk of misuse and addiction: Like other opioid pain relievers, Nucynta has a risk of misuse and addiction. With misuse, a drug is taken in a way other than how it’s prescribed. Addiction means taking a drug even if it’s causing harm. Misuse of Nucynta can lead to overdose and death. Due to this risk, your doctor will likely assess your risk of misuse before prescribing the drug and will monitor you throughout treatment. You should take Nucynta exactly as your doctor prescribes.

Nucynta is classified as a Schedule I controlled substance in the United States. A controlled substance is a drug the government regulates due to the risk of dependence or misuse. This means doctors and pharmacists must follow strict rules when prescribing and dispensing Nucynta. These rules are in place to help reduce the risk of misuse and addiction.

Because of these risks, healthcare professionals are strongly encouraged to complete a training program so they can educate people about the risks and safe use of opioids, including Nucynta. This is called an opioid analgesic risk evaluation and mitigation strategy (REMS). Your doctor or pharmacist will likely talk with you about how to take, store, and dispose of Nucynta safely. Your pharmacist will also give you a medication guide to read each time you fill your Nucynta prescription.

Risk of serious respiratory depression: Like other opioid pain relievers, Nucynta can cause serious or life threatening breathing problems, even at recommended dosages. This can include symptoms such as respiratory depression (slow, shallow breathing). This can happen at any time during treatment, but the risk is higher when starting the drug or after a dosage increase. Due to this risk, you should take Nucynta exactly as your doctor prescribes. If you’re prescribed Nucynta extended-release oral tablets (Nucynta ER), you should swallow the tablets whole. You should not cut, crush, chew, or dissolve the tablets. This could make the drug release too quickly and lead to overdose, which could be fatal. Immediately call 911 or go to the closest emergency room if you develop symptoms of respiratory depression.

Risk of accidental ingestion: Taking even one dose of Nucynta accidentally, especially by children, can lead to an overdose of Nucynta. This could cause respiratory depression or death. If you’re prescribed Nucynta, your doctor or pharmacist may recommend having naloxone on hand. Naloxone can help treat severe breathing problems that may occur if an opioid is taken. Also keep Nucynta in a safe, preferably locked place, where others can’t get to it, including children.

Risk of neonatal opioid withdrawal syndrome: If an opioid, including Nucynta, is needed during pregnancy for a long time, there is a risk of the infant having neonatal opioid withdrawal syndrome. Withdrawal describes symptoms that can occur when you stop taking a drug your body is dependent on. This can be life threatening if it’s not treated. Talk with your doctor about how to best manage pain during pregnancy. If you take Nucynta during pregnancy, the newborn must be monitored closely after delivery.

Risk of serious effects if taken with certain other medications or alcohol: Taking an opioid, like Nucynta, with certain other medications or alcohol can increase the risk of serious side effects. Examples of these medications include benzodiazepines or other drugs that can affect the central nervous system (CNS), such as sleeping pills or muscle relaxants. Taking these with Nucynta can increase the risk of symptoms such as excessive sleepiness, respiratory depression, coma, and death. Due to this risk, your doctor will likely not prescribe Nucynta with these drugs. For the same reason, your doctor will tell you to avoid alcohol during therapy with Nucynta or Nucynta ER. Consuming alcohol or products that contain alcohol together with Nucynta ER can increase blood levels of the drug and could lead to an overdose. Talk with your doctor to learn more about these risks.

You can talk with your doctor to learn more about these risks.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Article resources