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What’s the difference between high and low dose birth control?

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Low dose contraceptivesHigh dose contraceptivesDifferencesWho should avoid itSummary
High dose and low dose birth control pills contain different amounts of estrogen. Their effectiveness is similar, but some of their side effects and potential risks differ. 
Medically reviewed by Valinda Riggins Nwadike, MD, MPH
Written by Suan Pineda
Updated on

Birth control pills come in different types and dosages. There are two main types of oral contraception: combination pills and progestin-only pills.

The combination pill, most commonly just called “the pill,” often contains the hormones estrogen and progestin. Progestin is the human-made (synthetic) version of progesterone. Progestin-only pills, as their name indicates, contain only progestin.

Combination pills come in different doses:

  • Low dose: 35 micrograms (mcg) or less of a type of synthetic estrogen, like ethinyl estradiol
  • High dose: more than 50 mcg of estrogen

Combination pills can come in different types, such as monophasic and multiphasic. Monophasic pills contain the same dose of estrogen and progestin in each pill. Multiphasic pills contain varying weekly doses of estrogen and progestin.

Progestin-only pills, also known as the minipill, come in only a single dose: 35 micrograms of progestin. 

About 25% of females ages 15 to 44 in the United States have reported using birth control pills. Learning more about the benefits and disadvantages of low dose birth control pills versus high dose birth control medications, their key differences, and possible side effects can help you to choose the right birth control type for you.

Low dose birth control pills

A person sitting down holding a glass of water and contraceptive pills, representing the difference between high and low dose birth control
Luis Herrera/Stocksy United

Low dose birth control pills contain a lower dose of hormones. Low dose combination pills contain 10–35 mcg of estrogen.

Research from 2016 has shown that low dose birth control pills have the same effectiveness as high dose pills at preventing pregnancy, as long as you correctly and consistently take them. Low dose combination pills are 99% effective at preventing pregnancy when taken properly. 

Because combination birth control pills have been linked to several health conditions, health professionals are likely to prefer to prescribe low dose birth control pills. Potential risks of combination pills include:

Yet according to American Family Physician, low dose birth control pills have higher rates of discontinuation — meaning that people stop using them more often. This is because they have side effects like bleeding, nausea, headaches, and weight gain

Experts recommend that the best dose for most people who take oral birth control is between 30 and 35 mcg of ethinyl estradiol (synthetic estrogen). 

Low dose combination pills include these brands:

Low dose progestin-only birth control pills include the following brands:

Low dose birth control pills have some advantages and disadvantages, according to the U.K. National Health Service.

Pros of low dose birth control pills include:

  • It can reduce acne.
  • It can lower your risk of colon and ovarian cancer.
  • Your menstrual bleeding can be lighter, more regular, and less painful.
  • It can lower your risk of ovarian cysts and fibroids.

The cons of low dose birth control pills include:

  • It can cause side effects like nausea, vomiting, headaches, and breast tenderness.
  • It can raise your blood pressure.
  • It is linked to an increased risk of blood clots and breast cancer.
  • It can lead to breakthrough bleeding during the first months of use.

Remember that birth control pills, no matter their dosage, cannot protect you against sexually transmitted infections.

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High dose birth control pills

Health professionals rarely prescribe high dose birth control pills because low dose pills have the same effectiveness and a lower risk of side effects. 

High dose combination pills contain about 50 mcg of estrogen and progestin. These include the following brands:

  • Demulen 1/50
  • Ogestrel
  • Ortho-Novum 1/50
  • Ovral

The pros and cons of high dose birth control pills are similar to those of low dose pills. Yet high dose pills may lead to a higher risk of certain conditions than low dose pills, including breast cancer, according to some older 2014 research.

Differences between low dose and high dose pills

Besides the amount of estrogen, low dose and high dose birth control combination pills have some key differences:

Type of birth control pillDoseEffectivenessSide effects
low dose between 10 and 35 mcg of estrogen99%headaches, nausea, vomiting, more frequent bleeding and spotting between periods, changes in mood, breast tenderness
high dosemore than 50 mcg of estrogen The effectiveness of high dose and low dose combination pills is similar: About 9 in 100 people on the pill become pregnantless frequent bleeding and spotting between periods, higher risk of mood changes, linked to an increased risk of breast cancer, blood clots, and heart attacks

Who should not take combination birth control pills

Hormonal birth control pills are not for everyone. No matter the dosage, you should avoid taking birth control pills if you:

  • are pregnant
  • are overweight
  • have high blood pressure
  • smoke and are ages 35 or over, or stopped smoking less than a year ago 
  • have had a stroke  
  • have cardiovascular conditions or heart disease
  • have had blood clots
  • have liver or gallbladder problems
  • have breast cancer 
  • have diabetes complications

Summary

Birth control pills come in different types and different dosages. Birth control pills can be combined (containing both synthetic estrogen and progesterone) and progestin-only pills. 

Combined birth control pills can come in different doses as well. Low dose birth control pills contain 10–35 mcg of estrogen, while high dose birth control pills contain more than 50 mcg of estrogen. 

Health professionals prefer to prescribe lower dose birth control pills because research has shown that both low dose and high dose pills have about the same effectiveness. In addition, low dose birth control pills have lower risk of conditions like breast cancer, blood clots, and heart attacks. 

Birth control pills, no matter their dosage, can cause side effects like nausea, vomiting, and spotting.

You should talk with a healthcare professional if these symptoms persist and are affecting your quality of life. They may consider switching you to a different pill or a different birth control method.

Download the free Optum Perks Discount Card to save up to 80% on some prescription medications.

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