Synthroid, Thyquidity, Tirosint-sol, Tirosint, Ermeza

Cost of levothyroxine

Written by Sarah Lewis, PharmD
Medically reviewed by Alex Nguyen, PharmD, RPh, CPh
Updated on January 21, 2026

As with other medications, the cost of levothyroxine can vary. Certain factors may affect its price, such as:

• your insurance plan, if you have coverage
• the pharmacy you use
• whether you use coupons

To find out how much levothyroxine costs, ask your doctor, pharmacist, or insurance provider. They may be able to suggest ways to save money on your prescription, including those described in this article. To find out what the drug costs when using Optum Perks coupons, see the prices shown above on this page.

Need a diagnosis or prescription quickly? Optum Perks offers personalized on-demand care in as little as 15 minutes. For $29, answer a few questions online and receive a diagnosis and treatment plan from a US-licensed healthcare professional. Get started here.

Coupons for levothyroxine

Prescription drug coupons can help you save money by lowering the cost of levothyroxine. The Optum Perks coupons on this page above can provide significant savings on your prescription costs.

Drug prices often vary between pharmacies, such as CVS, Walmart, Rite Aid, and local pharmacies. Check the Optum Perks coupon list on this page above to find discounts available at pharmacies near you.

Note: Optum Perks coupons cannot be used with any insurance copays or benefits.

Available app for coupons

To make finding and using these coupons easier, you can download the Optum Perks app. To learn more about this prescription discount app, see this article.

Common questions about levothyroxine and cost

Here are some common questions about levothyroxine and their answers. 

How much does levothyroxine cost without insurance?

Insurance coverage is one of the main factors in the cost of prescription drugs. In general, the cost tends to be higher if you pay out of pocket instead of using insurance. But levothyroxine is a generic drug, and generics are usually more affordable than brand-name drugs.

If you’re paying for levothyroxine without insurance, you may be able to find online coupons to help with the cost. See the “Coupons for levothyroxine” section.

Is levothyroxine available over the counter (OTC)?

Levothyroxine is not available OTC. You need a prescription from a doctor to get this medication. The medication is not suitable for everyone to take, so speak with a healthcare professional for a diagnosis and prescription.

Need a diagnosis or prescription quickly? Optum Perks offers personalized on-demand care in as little as 15 minutes. For $29, answer a few questions online and receive a diagnosis and treatment plan from a US-licensed healthcare professional. Get started here.

Does levothyroxine 100 mcg cost less than levothyroxine 125 mcg?

It’s possible. Levothyroxine oral tablets, for example, come in many different strengths, from 25 micrograms (mcg) to 300 mcg. The dosage strength of your prescription may be a factor in the cost.

But there are other factors that affect cost, including insurance coverage. If you have insurance, your cost will depend on how your plan covers levothyroxine and the copay they charge for it.

You can find out how much you’ll pay for a levothyroxine prescription by contacting your insurance provider or pharmacy.

Why are costs different for brand-name drugs vs. generic drugs?

Brand-name drugs can be expensive because of the studies needed to test how safe and effective they are.

Makers of a brand-name drug can sell their drug for up to 20 years. When the patent for a brand-name drug expires, other drugmakers can make and sell generic versions. A generic medication is an identical copy of the active drug in a brand-name medication. (An active drug is the ingredient that makes a medication work.)

This competition may help keep the costs of generic medications lower. Also, generic medications contain the same active drugs as brand-name medications. So they don’t require the same testing, which can be costly.

If you’d like to know more about the cost differences between brand-name and generic drugs, talk with your doctor.

Resources

• Food and Drug Administration. (2025). Orange Book: Approved drug products with therapeutic equivalence evaluations. https://www.accessdata.fda.gov/scripts/cder/ob/index.cfm
• Levothyroxine sodium tablets, for oral use. (2025). https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/e3667ab1-2bd9-4e0d-8a97-f907593e7954/spl-doc

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.