Repatha Pushtronex, Repatha Sureclick, Repatha

Evolocumab On-Body Infusor

(e voe LOK ue mab)

Pushtronex System

It is used to lower cholesterol. It is used in some people to lower the chance of heart attack, stroke, and certain heart procedures.

If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. This drug may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists. Have blood work checked as you have been told by the doctor. Talk with the doctor. Follow the diet plan that your doctor told you about. High blood sugar has happened with this drug. This includes diabetes that is new or worse. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Nose or throat irritation. Flu-like signs. Signs of a common cold. Back pain. Irritation where the shot is given. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely. It is given into the fatty part of the skin on the top of the thigh, belly area, or upper arm. If you will be using this drug at home, your doctor or nurse will teach you how to use it. Wash your hands before and after use. If stored in a refrigerator, let this drug come to room temperature before using it. Leave it at room temperature for at least 45 minutes. Do not heat this drug. Do not open until you are ready to use. Do not touch the start button until you have put this device on your skin. This button can only be pushed 1 time. Do not get the device wet. Do not give into a mole, scar, or bruise. Do not put on skin with a lot of hair. Do not give into skin that is irritated, bruised, red, infected, or scarred. Move the site where you give this drug as you were told by the doctor. Do not give into the same place as another shot. Do not shake. Do not use this drug if it has been dropped or if it is broken. Do not use if the solution is cloudy, leaking, or has particles. This drug is colorless to a faint yellow. Do not use if the solution changes color. Call the doctor right away if you think that the device may not have worked the right way. Call the doctor right away if the On-body Injector comes off before or during a dose, if it is leaking, or if the sticky part is wet. Call the doctor right away if the light on the On-body Injector flashes red. Throw away after using. Do not use the device more than 1 time. Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

Take a missed dose as soon as you think about it. If it has been 7 days or more since the missed dose, take a missed dose and start a new schedule based on when the dose is given. Do not take 2 doses at the same time or extra doses. If you are not sure what to do if you miss a dose, call your doctor.

Store in a refrigerator. Do not freeze. If needed, you may store at room temperature for up to 30 days. If stored at room temperature and not used within 30 days, throw this drug away. If stored at a temperature higher than room temperature, talk with the doctor to see if this drug may still be used. Store in the original container to protect from light. Do not use if it has been frozen. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.