Skip to main content

Leptospirosis (Weil's Disease)


What is leptospirosis? — Leptospirosis is a disease that can cause fever, muscle aches, and headaches. It is caused by a germ that infects animals. The germ lives in the urine of animals that carry it.
The main way humans get leptospirosis is from water or soil with animal urine in it. The germ gets into the body through cuts or scrapes. It can also get in through the pink, moist tissues called "mucous membranes" that line your mouth, nose, eyes, and other body parts.
Animals that can carry leptospirosis include:
Rodents, such as rats and mice
Farm animals, such as cows, pigs, horses, sheep, and goats
Leptospirosis is more common in certain parts of the United States. These include Hawaii, the South, and the Pacific coast states. The disease is also common in South America, Central America, South Asia, and islands in the Pacific Ocean.
What are the symptoms of leptospirosis? — Leptospirosis can be mild or severe. Some people have no symptoms or very mild symptoms.
If symptoms do happen, they usually start suddenly. The main symptoms include:
Shaking chills
Muscle aches
Other symptoms include:
Whites of the eyes turning red
Dry cough
Nausea, vomiting, diarrhea, or belly pain
Pain in joints or bones
Sore throat
Some people get very sick with leptospirosis. They can have serious problems in the lungs, liver, muscles, and other body parts.
Will I need tests? — Yes. The doctor or nurse will ask about your symptoms and do an exam. He or she can order tests to check for leptospirosis or a different condition that might be causing symptoms. Tests can include:
Blood tests
Urine tests
Tests on samples of the fluid from your spinal cord (called "cerebrospinal fluid" or "CSF")
How is leptospirosis treated? — Most people who get leptospirosis get better on their own. But if you feel sick enough to see the doctor or nurse, he or she can prescribe an antibiotic medicine. You can take this medicine by mouth. This helps most people get well faster.
If you get very sick, you might need treatment in the hospital. Doctors can give antibiotics through an "IV." This is a thin tube that goes into a vein. Doctors can also give treatments for serious symptoms such as breathing problems, if you have them.
Can leptospirosis be prevented? — You can reduce your chances of getting leptospirosis by:
Staying away from water or soil that might be infected, such as:
•Puddles, ponds, or lakes where the water does not move much or has scum on it
•Water that could have animal waste in it – For example, water that drains from a farm or ranch
•Soil on a farm or ranch
Keeping rats and mice out of your house or yard
Not touching rats or mice
Keeping food and drinks away from animals
Getting your animals a vaccine (shot) against leptospirosis, if possible
There is no leptospirosis vaccine for humans in the United States.
All topics are updated as new evidence becomes available and our peer review process is complete.
This topic retrieved from UpToDate on: Mar 30, 2020.
Topic 83289 Version 4.0
Release: 28.2.2 - C28.105
© 2020 UpToDate, Inc. and/or its affiliates. All rights reserved.

6 popular Leptospirosis (Weil's Disease) drugs
  • $10.71+
    Doxycycline Hyclate
    Generic Doryx, Doryx Mpc, Vibramycin Monohydrate
    See prices
  • $80.69+
    Tetracycline Hcl
    Generic Tetracycline Hydrochlorid
    See prices
  • $2.8k+
    Bicillin L-a
    See prices
  • $50.80+
    Penicillin G Potassium
    See prices
  • $17.92+
    Generic Vibramycin Hylate
    See prices
  • $438+
    Penicillin G Sodium
    See prices

New! No Prescription? No problem.

Affordable Online Care is here! Answer a few questions about your concern and receive a treatment plan in as little as 15 minutes, from a board-certified provider, 100% online.

Learn more
Illustration of a prescription hand off from one mobile phone to another