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Medically Approved

Xarelto dosage: A detailed guide

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Forms and strengthsDosageFAQCouponOverdoseBoxed warning(s)
Doctors prescribe Xarelto to treat or prevent blood clots and for certain other conditions. You take it by mouth once or twice per day.
Medically reviewed by Melissa Badowski, PharmD, MPH, FCCP
Updated on

This article describes Xarelto’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for Xarelto. If you want to know more about Xarelto, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.

Xarelto is a brand-name medication that comes as an oral tablet and an oral suspension. It isn’t available in a generic version.

Xarelto oral tablet and oral suspension have a boxed warning for the risk of blood clots if this medication is stopped early. It also has a boxed warning for the risk of spinal or epidural hematoma if you undergo certain surgical procedures. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the end of this article.

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Forms and strengths of Xarelto

Xarelto comes in these forms and strengths: 

FormHow to takeStrengths
oral tablettake by swallowing• 2.5 milligrams (mg)
• 10 mg
• 15 mg
• 20 mg
oral suspensiontake by swallowing• 1 mg/milliliter (mL)

Dosage of Xarelto

This article describes the recommended dosages for Xarelto. The drugmaker provides these dosages. In some cases, doctors may adjust your dosage from those shown below.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of Xarelto without your doctor’s recommendation.

Usual recommended dosages of Xarelto in adults

The dosage of Xarelto will be based on the condition being treated or prevented.

Dosage of the oral tablet for atrial fibrillation (AFib), deep vein thrombosis (DVT), and other conditions

PurposeRecommended dose and frequency
reduce the risk of blood clots and stroke in people with AFib 15 mg or 20 mg once daily
treat DVT or pulmonary embolism (PE)15 mg twice daily for 21 days, then 20 mg once daily for the remainder of treatment
prevent a recurrence of DVT or PE 10 mg once daily
prevent DVT after knee or hip replacement surgery10 mg once daily
lower risk of heart problems if you have coronary artery disease2.5 mg twice daily
lower risk of blood clots if you have peripheral artery disease2.5 mg twice daily
prevention of venous thromboembolism (VTE)10 mg once daily for 31 to 39 days

Dosages of Xarelto in children

Xarelto is FDA approved for use in some children. Specifically it’s used to:

  • treat blood clots in children 2 years and older with congenital heart disease who had a type of open-heart surgery known as the Fontan procedure
  • treat or prevent a recurrence of VTE in children from birth to 18 years of age

In children, the dosage of Xarelto, for both the oral suspension and the oral tablet forms, is based on body weight. Your child’s doctor will use a chart to determine the correct dosage of Xarelto based on your child’s weight.

Xarelto oral tablets are taken once or twice per day. The oral suspension form of Xarelto is taken two to three times per day, depending on your child’s weight.

Talk with their doctor for more information about the dosage of Xarelto for children.

Frequently asked questions

Below are answers to some commonly asked questions about Xarelto and its dosage.

What is the maximum daily dosage of Xarelto?

The maximum daily dosage of Xarelto will vary depending on the condition that Xarelto is prescribed for.

Talk with your doctor or pharmacist for more information about the maximum daily dosage of Xarelto.

Is there a 10-mg dosage of Xarelto for atrial fibrillation (AFib)?

No, the recommended dosage of Xarelto for AFib is 15 mg to 20 mg once daily.

Talk with your doctor or pharmacist if you have questions about the dosage for AFib.

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Overdose of Xarelto

It’s important that you do not take more Xarelto than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of Xarelto overdose

Xarelto overdose may cause bleeding, which could be severe.

What to do if you take too much Xarelto

If you think you’ve taken too much Xarelto, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

Boxed warnings for Xarelto

Xarelto has a boxed warning for the risk of risk of blood clots if this drug is stopped early. It also has a boxed warning for the risk of spinal or epidural hematoma if you undergo certain surgical procedures. A boxed warning is the most serious warning from the FDA.

Risk of blood clots if you stop treatment early: Stopping Xarelto before your treatment plan is finished increases the risk of blood clots, which can lead to a stroke or other serious conditions. It’s important that you do not stop taking Xarelto without first talking with your doctor.

Risk of spinal or epidural hematoma during certain surgical procedures: Taking Xarelto may increase your risk of a spinal or epidural hematoma (blood pooling in your spinal cavity) if you undergo anesthesia or a lumbar puncture. This could result in long-term or permanent paralysis. Your doctor will determine your risk factors before prescribing Xarelto.

Talk with your doctor for more information.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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