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Wegovy interactions: A detailed guide

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Other drugsFAQOther interactionsWhen to avoidAlcoholHealth factorsPreventionAsk your doctorBoxed warning
Wegovy is prescribed to help with weight loss in certain people. This drug may interact with other medications and some supplements. Specifically, it can interact with insulins and sulfonylureas.
Medically reviewed by Amber R. Watson, PharmD
Updated on

This article describes possible interactions with Wegovy. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.

Wegovy comes as a liquid solution that’s injected under the skin.

Boxed warning: Risk of thyroid cancer

Wegovy has a boxed warning for the risk of thyroid cancer. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

See the end of this article for more information about this warning.

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Other drugs and Wegovy

The drugs in the list below may interact with Wegovy. This article doesn’t include all drugs that may interact with Wegovy. Talk with your doctor or pharmacist to find out what medications you should not take with Wegovy.

Drug classes or drugs that may interact with Wegovy include:

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Questions about Wegovy and interactions

Here you’ll find answers to some common questions about Wegovy and possible interactions.

Can I take Wegovy and phentermine together?

It’s not known if taking Wegovy and phentermine together is safe. Your doctor may not recommend taking this combination as phentermine is used for weight management as well.

Wegovy can’t be used and has a limitation of use with other medications for weight management. This is because the safety of using Wegovy with another weight management drug, such as phentermine, isn’t known. A limitation of use is a note to doctors and pharmacists about situations in which the risk or benefit of using a drug for a certain purpose isn’t known.

You shouldn’t use Wegovy with phentermine or another drug for weight management unless you and your doctor agree that the benefits outweigh the risks and they prescribe you this combination.

Talk with your doctor or pharmacist if you have questions about taking Wegovy and phentermine together.

Is there an interaction between Wegovy and antidepressants? Can you take Wegovy together with Wellbutrin or Zoloft?

Yes, Wegovy may interact with certain antidepressants. Examples include Nardil (phenelzine) and Prozac (fluoxetine). However, Wegovy isn’t known to interact with Wellbutrin or Zoloft. (To learn more about the drugs that Wegovy interacts with, see the “Other drugs and Wegovy” section above.)

Be sure to review all your medications and health conditions with your doctor before you begin using Wegovy. They can discuss whether there’s an interaction that affects you.

If you’d like to know more about Wegovy and antidepressants, talk with your doctor or pharmacist.

Can you take Wegovy and Adderall together?

Possibly. There’s no known interaction between Wegovy and Adderall. (Adderall is used to treat attention deficit hyperactivity disorder and narcolepsy.)

But, Adderall has other interactions with medications and health conditions. Depending on your health history, these interactions can affect whether Adderall is safe for you to take.

Talk with your doctor or pharmacist to learn more about whether Adderall interacts with any of your medications or health conditions.

Is there an interaction between Wegovy and ibuprofen?

No, there’s no known interaction between Wegovy and ibuprofen. These medications should be safe to take together. Ibuprofen is an NSAID used to treat pain and inflammation (swelling).

However, Wegovy may interact with certain other NSAIDs. Examples include magnesium salicylate (Doan’s) and aspirin. Like ibuprofen, certain other NSAIDs are available over the counter. To learn more about the drugs that Wegovy interacts with, see the “Other drugs and Wegovy” section above.)

You should check with your doctor or pharmacist before taking any over-the-counter NSAIDs with Wegovy. They can check for interactions and recommend whether the drug is safe for you to take.

Other interactions and Wegovy

Interactions can occur with foods, supplements, vaccines, and some lab tests. Below you can learn whether Wegovy has these interactions. 

The information below doesn’t include all other possible interactions with Wegovy.

Wegovy and food

Wegovy isn’t known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.

It’s important to note that certain mineral supplements that interact with Wegovy may also be found in certain foods or drinks. An example is chromium. However, this mineral isn’t usually present in high enough levels in foods to interact with Wegovy. See the “Wegovy and supplements” section just below for more information.

Because of this, talk with your doctor or pharmacist about what foods to avoid when using Wegovy.

Wegovy and supplements

Before using Wegovy, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.

In addition to the interactions below, Wegovy can interact with several supplements. These include:

Using Wegovy with these supplements may increase the risk of low blood sugar. Because of this risk, talk with your doctor before taking any supplements while using Wegovy. They can check for interactions and recommend whether the supplement is safe for you to take.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Wegovy interactions with herbs

There are no specific reports of herbs interacting with Wegovy. However, certain herbs could possibly increase the risk of having low blood sugar if taken with Wegovy.

Because of this, ask your doctor or pharmacist before taking any herbal products while using Wegovy.

Wegovy interactions with vitamins and minerals

Wegovy may interact with the mineral chromium. This vitamin is often used for sports performance and general health.

Using Wegovy and a chromium supplement may increase the risk of low blood sugar.

Because of this, ask your doctor or pharmacist before taking any of these products while using Wegovy.

Wegovy and vaccines

Wegovy isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist before receiving any vaccines while using Wegovy.

Wegovy and lab tests

Wegovy isn’t known to interact with lab tests. But this doesn’t mean interactions with lab tests can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist before having any tests while using Wegovy.

Wegovy and cannabis or CBD

Wegovy isn’t known to interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But this doesn’t mean interactions can’t happen or won’t be identified later.

As with any drug or supplement, tell your doctor before taking cannabis with Wegovy.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

When to avoid Wegovy

Certain health conditions or other factors could increase some risks with Wegovy. Because of this, doctors may not prescribe Wegovy in these cases. These health conditions or other factors are called contraindications.

Here’s a list of contraindications for Wegovy:

  • Personal or close family history of medullary thyroid carcinoma (MTC): If you or a family member ever had MTC (a type of thyroid cancer)* using Wegovy may worsen your condition.
  • Personal history of multiple endocrine neoplasia syndrome type 2 (MEN2): If you have MEN2, using Wegovy may further increase your risk of thyroid cancer. (MEN2 is a type of inherited endocrine condition that can cause thyroid cancer.*)
  • Past allergic reaction to Wegovy: If you’ve ever had an allergic reaction to Wegovy, using it again may cause another allergic reaction.

Before you start using Wegovy, tell your doctor if anything listed above relates to you. They can recommend whether you should take Wegovy.

* Wegovy has a boxed warning for thyroid cancer. A boxed warning is the most serious warning from the FDA. To learn more, see the “Boxed warning for Wegovy” section below.

Alcohol and Wegovy

Wegovy is not known to interact with alcohol.

However, alcohol consumption plays a role in weight management and can affect weight loss. Wegovy is prescribed along with lifestyle changes, such as diet and exercise, to help with weight loss. Because alcohol contains “empty calories“, your doctor or dietician may suggest you lower or avoid consuming alcohol to help with weight management.

If you drink alcohol, talk with your doctor about how drinking it can affect your weight management plan while using Wegovy.

Health factors and Wegovy

Certain medical conditions or other health factors may increase the risk of interactions with Wegovy. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before using Wegovy, tell your doctor about your health history. They’ll determine whether Wegovy is right for you.

These health conditions or other factors might interact with Wegovy:

* Wegovy has a boxed warning for thyroid cancer. A boxed warning is the most serious warning from the FDA. To learn more, see the “Boxed warning for Wegovy” section below.

Suicide prevention

If you or someone you know is in crisis and considering suicide or self-harm, please seek support:

If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely.

If you are not in the same household, stay on the phone with them until help arrives.

Preventing Wegovy interactions

You may be able to help avoid certain interactions with Wegovy. Before using this drug, you may want to discuss possible interactions with your doctor and pharmacist.

Things to consider include:

Using Wegovy exactly as prescribed can also help prevent interactions.

What to ask your doctor

If you have questions about Wegovy and possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

  • Should I tell you if I start taking another medication or supplement during my Wegovy treatment?
  • How do interactions of Wegovy compare with those of phentermine?
  • Could I still take Wegovy even if it interacts with a health condition I have?

Boxed warning for Wegovy

Wegovy has a boxed warning for the risk of thyroid cancer. A boxed warning is the most serious warning from the FDA.

In animal studies, Wegovy increased the risk of certain thyroid cancers. This includes a type of thyroid cancer called medullary thyroid carcinoma (MTC). It’s important to note that animal studies don’t always predict the effects a medication will have on humans.

Because of this risk, doctors won’t typically prescribe Wegovy if you or a close family member ever had MTC. They also won’t prescribe Wegovy if you have an inherited endocrine condition called multiple endocrine neoplasia syndrome type 2.

If your doctor prescribes Wegovy to you, they’ll monitor you closely for signs of thyroid cancer. Talk with your doctor right away if you notice symptoms such as a hoarse voice or difficulty swallowing.

To learn more, talk with your doctor.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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