Neuropathy can cause pain, burning, and tingling sensations throughout the body, especially in the hands and feet. It can result from various health conditions and related issues, such as diabetes, chemotherapy, exposure to toxins, injuries, infections, and tumors.
Doctors can prescribe medication to relieve the pain, but supplements may also help.
Before starting supplements, you should speak with a doctor, as supplements can cause side effects and interact with other medications.
A doctor can advise whether supplements are suitable, suggest which ones to take, and recommend reliable brands.
This article focuses on supplements that may reduce nerve pain and other treatment options for improving neuropathy.
1. Acetyl-l-carnitine
ALC is an amino acid that the kidneys and liver produce naturally. It may help manage various symptoms, including nerve pain.
It may also help people with diabetic neuropathy or those who are undergoing chemotherapy.
However, one 2022 review showed inconsistent research results. In some studies, participants said it provided relief from neuropathy. But in other studies, people with diabetic neuropathy didn’t notice a significant improvement in nerve pain.
According to the review, the results of some older research suggest that taking ALC supplements may worsen neuropathy in people undergoing chemotherapy.
2. Alpha-lipoic acid
Alpha-lipoic acid (ALA) supplements may help relieve the tingling and burning sensation that occurs with diabetic neuropathy.
However, research hasn’t confirmed that it’s effective.
A 2022 review analyzed eight trials involving 1,500 people with diabetes. About 37% of participants in these trials noticed an improvement in diabetic neuropathy symptoms when taking ALA supplements.
The same review reports five out of eight trials didn’t find enough evidence to prove that taking ALA supplements can improve nerve pain.
3. B-complex vitamins
Vitamin B-complex supplements may improve nerve pain.
A 2021 study found that vitamins B1, B6, B9, and B12 can help treat neuropathy.
The research found that vitamin B6 can help improve sensory nerve conduction, while vitamin B12 plays a key role in nerve repair.
You can find vitamin B1 in oranges, meat, and other vegetables. You can also find vitamin B in vitamin B-fortified cereals and oatmeal.
4. Calcium
Calcium keeps your bones strong and healthy. It also has a crucial role in regenerating nerves, ensuring that they continue to function effectively.
Calcium may improve neuropathy symptoms, although no studies have confirmed this.
5. Glutamine
Glutamine is the most abundant amino acid in the body. The human body uses it to produce proteins.
A 2016 study found glutamine may improve neuropathy and other symptoms people may experience during chemotherapy treatment. But according to a 2018 study, glutamine didn’t reduce or prevent any side effects of chemotherapy.
More research is needed to confirm that glutamine is effective in improving nerve pain.
Glutamine is present in foods such as:
- corn
- egg whites
- milk
- barley
- peanuts
- soybeans
- wheat
6. Glutathione
Glutathione is an antioxidant that the human body produces naturally.
In 2017, a study on animals found that peripheral neuropathy may improve with increased glutathione intake.
However, more studies are needed to confirm its efficacy in humans.
7. Magnesium
Magnesium is a mineral responsible for many intracellular functions, including enzyme reactions and transporting nerve signals and information.
A 2018 study found that people who receive chemotherapy treatment, have higher levels of magnesium, and eat a magnesium-rich diet, are less likely to experience nerve pain.
According to a 2022 review, some research showed that magnesium improved nerve pain. But in other research, magnesium made it worse.
More research is necessary to confirm that magnesium supplements can help treat neuropathy.
8. N-acetyl cysteine
N-acetyl cysteine (NAC) is an antioxidant that may help protect the neurological system from inflammation and damage.
A 2019 study found that people with diabetic neuropathy saw an improvement in their symptoms after taking NAC for 8 weeks.
However, more research is needed to confirm the efficacy of NAC in treating chronic nerve pain.
NAC is present in foods such as:
- lentils
- bananas
- beans
Learn more about prescription supplements.
Medical treatments for nerve pain
If you’re experiencing nerve pain, your doctor can prescribe different types of medication depending on how severe your symptoms are.
Medications to treat nerve pain may include:
- anticonvulsants, such as gabapentin (Neurontin) and pregabalin (Lyrica)
- some antidepressant drugs, such as amitriptyline and doxepin
- oral nonsteroidal anti-inflammatory drugs, such as ibuprofen and naproxen, although a 2015 review couldn’t confirm whether they help or not
- topical preparations, such as lidocaine, ketamine, and cannabidiol
Your doctor may also prescribe a combination of drugs rather than a single medication.
A 2017 study found that taking certain combinations of antidepressants alongside anticonvulsants may be more effective than taking either alone.
If you need help covering the cost of medications, the free Optum Perks Discount Card could help you save up to 80% on prescription drugs. Follow the links on drug names for savings on that medication, or search for a specific drug here.
