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Spironolactone oral tablet vs furosemide oral tablet: A detailed guide

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CostBrand namesUsesDosageSide effectsFAQWarningsWhat to ask
Spironolactone oral tablet and furosemide oral tablet are generic prescription drugs used to treat fluid retention caused by certain conditions. These medications come as tablets you take by mouth.
Medically reviewed by Christina Bookwalter PharmD, MS MEd, BCPS, BCACP
Updated on

This article explains how spironolactone oral tablet and furosemide oral tablet are similar and different. You can view detailed articles about spironolactone oral tablet and furosemide oral tablet if you’d like more information about these drugs.

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Cost of spironolactone and furosemide

As with the cost of other medications, the cost of spironolactone oral tablet and furosemide oral tablet can vary. Their price may be affected by:

  • whether they’re covered by health insurance, if you have coverage
  • the pharmacy they’re purchased from

Coupons and cost savings

To view drug prices when Optum Perks coupons are applied, see this coupon page for spironolactone oral tablet and this coupon page for furosemide oral tablet. You can also check with your doctor, pharmacist, or insurance provider.

The options described in this article may also help you save on your prescription.

Download the free Optum Perks Discount Card to save up to 80% on some prescription medications.

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Brand-name versions

Below is information about whether spironolactone oral tablet or furosemide oral tablet is available in a brand-name version.

Both spironolactone oral tablet and furosemide oral tablet are generic medications.

A generic medication is an identical copy of the active ingredient in a brand-name medication. An active ingredient is what makes medication work.

Generics usually cost less than brand-name drugs. And they’re believed to be as safe and effective as the brand-name version.

Here’s a summary about brand-name versions of spironolactone oral tablet and furosemide oral tablet:

 spironolactone oral tabletfurosemide oral tablet
Active ingredientspironolactonefurosemide
Available brand-name version AldactoneLasix

Uses of spironolactone and furosemide

Here’s a summary of the approved uses of spironolactone oral tablet and furosemide oral tablet:

 spironolactone oral tabletfurosemide oral tablet
Approved uses• treat heart failure
• treat high blood pressure, used with other medications
• treat fluid retention related to cirrhosis or nephrotic syndrome
• treat primary hyperaldosteronism in certain situations
• treat fluid retention related to heart failure
• treat fluid retention related to cirrhosis
• treat fluid retention related to nephrotic syndrome or other kidney condition
• treat high blood pressure, used with other medications
Prescribed toadultsadults and children of any age

Spironolactone oral tablet and furosemide oral tablet are prescribed together with other medications for treating high blood pressure. They’re also frequently prescribed together with other medications for treating other conditions listed above.

If you’d like to know more about taking either medication for your condition, ask your doctor. They can recommend whether spironolactone oral tablet or furosemide oral tablet is an option to consider.

Dosage of spironolactone and furosemide

Below is dosage information for the conditions that both spironolactone oral tablet and furosemide oral tablet are prescribed to treat. To find detailed dosage information for all conditions that spironolactone oral tablet and furosemide oral tablet treat, see these articles about spironolactone oral tablet dosage and furosemide oral tablet dosage.

Dosages of spironolactone oral tablet and furosemide oral tablet below are provided by the drugmakers. If your doctor prescribes either medication, you should follow the dosage they prescribe. They’ll advise on the dosage that’s best for your condition. Do not adjust your dosage without first talking with your doctor.

Spironolactone oral tablet’s dosage

Below is a summary of spironolactone oral tablet’s recommended dosages in adults. Strength is measured in milligrams (mg).

ConditionHow it’s takenRecommended doseFrequency
treat high blood pressure, used with other medications in adults by mouth25–100 mgonce or twice daily
treat heart failure in adults by mouth 25–50 mgonce per day
treat fluid retention related to cirrhosis  by mouth25–200 mgonce or twice daily
treat fluid retention related to nephrotic syndrome by mouth25–200 mgonce or twice daily

Furosemide oral tablet’s dosage

Below is a summary of furosemide oral tablet’s recommended dosages in adults. Strength is measured in milligrams (mg).

ConditionHow it’s takenRecommended doseFrequency
treat high blood pressure, used with other medications in adults  by mouth40 mgtwice per day
treat heart failure in adults  by mouth20–80 mgonce per day
treat fluid retention related to cirrhosis  by mouth20–80 mgonce per day
treat fluid retention related to nephrotic syndrome by mouth20–80 mgonce per day

Side effects of spironolactone and furosemide

Spironolactone oral tablet and furosemide oral tablet may cause mild or serious side effects. Some of the more common mild side effects of each drug are listed below. Serious side effects of spironolactone oral tablet and furosemide oral tablet are also listed.

Keep in mind that your side effects may differ from those listed below. They can vary based on your overall health, any other medications you take, and your age.

This article doesn’t include all possible side effects of these medications. To find more information, you can view the prescribing information for spironolactone oral tablet and furosemide oral tablet. You can also check out these articles about spironolactone oral tablet side effects and furosemide oral tablet side effects.

Mild side effects

Below are some of the mild side effects reported with spironolactone oral tablet and furosemide oral tablet:

 spironolactone oral tabletfurosemide oral tablet
dizziness ✓
leg cramps 
abdominal cramps
urinating more frequently 
mild allergic reaction

Serious side effects

Below are serious side effects reported with spironolactone oral tablet and furosemide oral tablet:

 spironolactone oral tabletfurosemide oral tablet
boxed warning: risk of dehydration and electrolyte loss*
dehydration, which can lead to low blood pressure ✓
tinnitus or hearing loss
liver problems, such as jaundice
orthostatic hypotension (dizziness on standing up)
kidney problems, including kidney failure
high blood potassium levels 
digestive problems, including stomach ulcer or bleeding
pancreatitis (inflammation of the pancreas)
abnormal breast growth in males†
serious allergic reaction ✓ ✓

* For details about this side effect, see the “Warnings for spironolactone oral tablet and furosemide oral tablet” section below.
Sex and gender exist on spectrums. In this article, we use the term “male” to refer to a person’s sex assigned at birth.

With a lot of drugs, serious side effects are possible, but they’re not common. If you have serious side effects from spironolactone oral tablet or furosemide oral tablet, call your doctor right away. If your symptoms are severe or you’re having a medical emergency, call 911 or a local emergency number.

Questions about spironolactone and furosemide

Below, you’ll find answers to some common questions about spironolactone oral tablet and furosemide oral tablet.

Is it safe to take spironolactone and furosemide together?

Maybe. There’s no reported direct interaction between spironolactone and furosemide.

Spironolactone oral tablet and furosemide oral tablet are both diuretics (water pills), but they work in different ways. Generally, furosemide is considered a stronger diuretic. Spironolactone may be used with furosemide because furosemide causes your body to lose potassium, while spironolactone signals your body to retain potassium.

Both drugs are approved for similar uses and may be combined for certain conditions. For example, the combination of spironolactone and furosemide may be used to treat heart failure and cirrhosis with ascites.

Talk with your doctor or pharmacist to learn more about whether this combination is a potential treatment for your condition.

Between spironolactone and furosemide, is one a better treatment for swelling or fluid buildup?

Doctors may prescribe either spironolactone or furosemide to treat swelling or fluid buildup. In studies, spironolactone oral tablet and furosemide oral tablet were both effective for this purpose.

Keep in mind that your results from taking spironolactone oral tablet or furosemide oral tablet may differ from those seen in studies.

Generally, furosemide oral tablet is considered a stronger diuretic than spironolactone oral tablet. So it may be preferred over spironolactone for treating swelling or fluid buildup. But keep in mind that this depends on factors such as the condition treated, other medications you take, and your health history.

Your doctor can help determine whether one drug is better than the other for your condition. They’ll recommend this based on your specific needs and health factors.

Talk with your doctor if you’d like to learn more about which drug is right for you.

Warnings for spironolactone and furosemide

Some medications may not be recommended for you if you have certain factors affecting your health. These are referred to as a drug’s warnings.

Some people should not take spironolactone oral tablet or furosemide oral tablet, and others should use either medication with caution.

Warnings for spironolactone oral tablet and furosemide oral tablet are summarized below. Before using either medication, talk with your doctor about your health conditions, past surgeries, and any medications you take. Your doctor can recommend whether either drug is safe for you.

Boxed warning for furosemide oral tablet

Furosemide has a boxed warning about the risk of dehydration and electrolyte loss. Boxed warnings are the most serious warnings from the Food and Drug Administration (FDA).

Furosemide is a powerful diuretic (drug that relieves swelling and fluid retention). It can cause serious side effects, including dehydration and electrolyte loss. Examples of electrolyte loss include causing a low potassium or low sodium level in the blood. This risk increases with higher furosemide doses. Due to this risk, it’s important that you take furosemide exactly as directed by your doctor. They’ll monitor you closely during treatment for signs of dehydration or electrolyte problems.

If you have concerns about dehydration or electrolyte loss, tell your doctor. They’ll likely recommend ways to stay hydrated and maintain your electrolyte levels while taking furosemide. They can also advise on symptoms of these side effects to watch for, and when you should contact your doctor regarding side effect symptoms.

To learn more, talk with your doctor or pharmacist.

Other warnings

Besides the boxed warning for furosemide, warnings for spironolactone oral tablet and additional warnings for furosemide oral tablet are summarized in the table below:

 spironolactone oral tabletfurosemide oral tablet
Addison’s disease
anuria (not producing urine) 
electrolyte problem, such as low blood sodium level
condition affecting hearing, such as tinnitus
arrhythmia
conditions affecting the bladder or urination, such as an enlarged prostate gland
type 1 or 2 diabetes
gout
lupus
blood disorders, such as low white blood cell count
kidney conditions, such as chronic kidney disease
liver conditions, such as alcohol-related liver disease
allergic reaction to either drug or any of their ingredients ✓ ✓
currently pregnant or planning to become pregnant ✓ ✓
currently breastfeeding or planning to breastfeed ✓ ✓

You can view more detailed articles about spironolactone oral tablet and furosemide oral tablet if you’d like to know more about warnings for these drugs. You can also view the prescribing information for spironolactone oral tablet and furosemide oral tablet.

What to ask your doctor

If you’re trying to decide whether spironolactone oral tablet or furosemide oral tablet is better for you, talk with your doctor. They can recommend the best option.

Here’s a list of questions you may want to ask your doctor:

  • Is there a reason why spironolactone might be better for my condition than furosemide?
  • Will furosemide or spironolactone interact with any other drugs I’m taking?
  • How long should it take before I feel a difference from taking furosemide or spironolactone?

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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