This article describes Repatha’s dosages and strengths and gives details on how it’s given. You’ll also find information on cost savings and coupon options for Repatha. If you want to know more about Repatha, see this overview article. It covers details about the drug’s uses, side effects, ways to save on cost, and more.
Repatha is a brand-name medication that comes as a liquid solution injected under the skin. It isn’t available in a biosimilar version.
Dosage of Repatha
This article describes the recommended dosages for Repatha. The drugmaker provides these dosages. In some cases, doctors may adjust your dosage from those shown below.
If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of Repatha without your doctor’s recommendation.
Usual recommended dosages of Repatha in adults
Below are the recommended dosages of Repatha in adults.
Dosage for lowering cholesterol and certain risks
To lower cholesterol and risks due to certain heart-related conditions, the dosages of Repatha expressed in milligrams (mg) are as follows:
| Purpose | Recommended dose and frequency |
|---|---|
| lower low-density lipoprotein (LDL) cholesterol in adults with homozygous familial hypercholesterolemia (HoFH) | 420 mg once monthly and then after 12 weeks, your doctor may increase it to 420 mg every 2 weeks if needed |
| lower LDL in adults with hyperlipidemia or heterozygous familial hypercholesterolemia (HeFH) | 140 mg every 2 weeks or 420 mg once monthly |
| lower the risk of heart attack, stroke, and heart surgery in adults with cardiovascular disease | 140 mg every 2 weeks or 420 mg once monthly |
You’ll inject Repatha under your skin using a syringe, autoinjector, or on-body infuser. (To learn more about these forms, see the “Forms and strengths of Repatha” section below.) Your doctor may advise you to inject Repatha into your thigh, stomach, or upper arm. For details on how to inject Repatha, see the drug’s prescribing information or manufacturer’s website.
There’s no best time of day to inject Repatha. Your doctor may advise that you inject this medication according to a certain schedule.
Dosages of Repatha in children
Repatha is approved to lower LDL cholesterol in children ages 10 years and older who have HoFH or HeFH. The dosages are as follows:
| Purpose | Recommended dosage and frequency |
|---|---|
| lower LDL cholesterol in children with HoFH | 420 mg once monthly, and then after 12 weeks, your child’s doctor may increase it to 420 mg every 2 weeks if needed |
| lower LDL cholesterol in children with HeFH | 140 mg every 2 weeks or 420 mg once monthly |
For more information about how Repatha is injected, see the “Usual recommended dosages of Repatha in adults” section just above.
Forms and strengths of Repatha
Repatha injection comes in the following forms and strengths expressed in milligrams per milliliter (mg/mL):
| Form | How to receive | Strength |
|---|---|---|
| single-dose prefilled syringe | inject under the skin | 140 mg/mL |
| single-dose prefilled SureClick autoinjector | inject under the skin, delivering the dose in up to 15 seconds | 140 mg/mL |
| Pushtronex system* | infuse under the skin, delivering the dose in about 5 minutes | 420 mg/3.5 mL |
* The Pushtronex system is a single-dose on-body infuser that contains a prefilled cartridge. It infuses the medication under your skin over 5 minutes. This form will be discontinued by the manufacturer on June 30, 2024. For more information, see the manufacturer’s website.
Frequently asked questions
Below are answers to some commonly asked questions about Repatha and its dosage.
If my Repatha dosage increases, will the risks of side effects increase?
It’s possible that your risk of side effects from Repatha may increase if your dosage increases. But in studies, the risk of side effects was similar between the once monthly and every 2 week dosing.
Talk with your doctor if you have questions about your Repatha dosage and side effects. For more information on Repatha dosages, see the “Dosage of Repatha” section above. To learn more about the side effects of Repatha, see this article.
Is Repatha used long term?
Doctors typically prescribe Repatha as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.
Talk with your doctor for more information about how long you’ll take Repatha.
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Get free cardOverdose of Repatha
It’s important that you do not inject more Repatha than your doctor prescribes. Doing so can lead to harmful effects.
What to do if you inject too much Repatha
If you think you’ve injected too much Repatha, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.