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Medically Approved

Pioglitazone oral tablet dosage: A detailed guide

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Form and strengthsDosageFAQHow it’s takenCouponOverdoseAsk your doctorBoxed warning
Doctors prescribe pioglitazone oral tablet to help improve blood sugar levels, along with diet and exercise, in adults with type 2 diabetes. You take it by mouth once per day.
Medically reviewed by Fallon Mumford, PharmD
Updated on

This article describes pioglitazone oral tablet’s dosages and strengths and gives details on how to take it. You’ll also find information on savings and coupon options for pioglitazone. If you want to know more about pioglitazone oral tablet, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.

Pioglitazone oral tablet is a generic version of the brand-name drug Actos.

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Boxed warning: Risk of congestive heart failure

Pioglitazone has a boxed warning for the risk of congestive heart failure. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

See the end of this article for more information about this warning.

Form and strengths of pioglitazone

Pioglitazone oral tablet comes as follows:

  • Form: tablet that you swallow
  • Strengths: 15 milligrams (mg), 30 mg, and 45 mg

Dosage of pioglitazone

This article describes the recommended dosages for pioglitazone oral tablet. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of pioglitazone oral tablet without your doctor’s recommendation.

Usual recommended dosages of pioglitazone in adults

Pioglitazone oral tablet is prescribed to help improve blood sugar levels in adults with type 2 diabetes, together with diet and exercise.

Usually, doctors start by prescribing a low dosage of pioglitazone oral tablet. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of pioglitazone oral tablet that gives the desired outcome.

  • Starting dosage: 15 mg or 30 mg once per day
  • Maintenance dosage: 15–45 mg once per day
  • Maximum dosage: 45 mg once per day

Dosage adjustments for pioglitazone

Your doctor will prescribe a dosage of pioglitazone oral tablet based on the health of your heart. This is because pioglitazone oral tablet may cause or worsen heart failure in some people.

If you have early stage heart failure, doctors usually prescribe a low dosage of pioglitazone oral tablet. If you have heart failure that’s causing symptoms, your doctor likely won’t prescribe pioglitazone oral tablet to help manage your type 2 diabetes.

Missed dose of pioglitazone

Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of pioglitazone oral tablet. They may advise you to take the missed dose. Or they may advise you to skip it and take your next dose as scheduled.

For tips on how to plan your doses of pioglitazone oral tablet and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about pioglitazone oral tablet and its dosage.

Can pioglitazone be taken for fatty liver disease? If so, what’s the dosage?

Pioglitazone might be taken for fatty liver disease. But it’s not specifically approved for this purpose. Pioglitazone oral tablet is approved to help improve blood sugar levels in adults with type 2 diabetes. But, in some cases, doctors may choose to prescribe it for fatty liver disease anyway. It’s called an off-label use when doctors prescribe a drug for conditions other than its approved uses.

To learn more about taking pioglitazone for fatty liver disease, talk with your doctor.

Do I need to take my dose of pioglitazone before or after food?

No, you don’t have to take pioglitazone oral tablet before or after food. You can take it with or without food. Try to take it when it’s easiest for you to remember. If taking it with a meal will help you remember, it’s OK to take your dose of pioglitazone with food. If another time works better, it’s fine to take it without food.

Talk with your doctor or pharmacist if you have more questions about taking pioglitazone before or after a meal.

Is pioglitazone taken long term?

Yes, doctors typically prescribe pioglitazone oral tablet as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

If you have questions about how long you should take pioglitazone oral tablet, talk with your doctor.

How pioglitazone is taken

You’ll swallow pioglitazone oral tablet once per day. You can take your dose of pioglitazone with or without food.

Your doctor may advise that you take this medication around the same time each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

If it’s hard for you to swallow tablets, view this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

Pioglitazone coupon

Visit this page to access Optum Perks coupons and get price estimates for pioglitazone when you use the coupons. These coupons can provide significant savings on your prescription costs. 

Note: Optum Perks coupons cannot be used with insurance copays or benefits.

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Overdose of pioglitazone

It’s important that you do not take more pioglitazone oral tablet than your doctor prescribes. Doing so can lead to harmful effects.

What to do if you take too much pioglitazone

If you think you’ve taken too much pioglitazone, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for pioglitazone oral tablet. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of pioglitazone oral tablet without your doctor’s recommendation. You should take pioglitazone oral tablet exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • Will my dosage of pioglitazone oral tablet be increased if my current dosage isn’t working?
  • Will my dosage of pioglitazone oral tablet change if I take other drugs with it?
  • Will my dosage change if I get sick or have an infection?

Boxed warning for pioglitazone

Pioglitazone has a boxed warning for the risk of congestive heart failure. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

If you have heart failure, your doctor may need to adjust your dosage of pioglitazone oral tablet.

You can also talk with your doctor to learn more.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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