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What causes muscle weakness? Plus treatment options

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ExerciseAge-relatedVitamin deficienciesChronic fatigueMultiple sclerosisHormonesNeurological conditionsSubstance useMedicationsCOVID-19Contacting a doctorSummary
Muscle weakness has many causes, including muscle fatigue, infection, or typical aging. Less often, it can be due to a chronic health condition.
Medically reviewed by Angelica Balingit, MD
Written by Jamie Smith
Updated on

Muscle weakness is when your muscles can’t function at their usual capacity. This is common and is usually not a concern. Depending on the cause, muscle weakness might affect your shoulders, legs, face, arms, hips, or other body parts.

Everyday causes of muscle weakness include:

  • excessive movement, such as exercise, walking long distances, or physical labor
  • fatigue or a lack of sleep
  • a recent viral or bacterial infection that’s left you feeling weak

In other cases, muscle weakness may signal a health condition, such as multiple sclerosis (MS), chronic fatigue syndrome (CFS), or a hormone imbalance.

If you’re concerned about new, sudden, or persistent muscle weakness, consider talking with a doctor. They can assess your symptoms and suggest the most appropriate treatments or remedies.

1. Excessive movement

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The first cause a healthcare professional will rule out is muscle fatigue.

You might have noticeably weaker muscles after starting a new exercise regime or returning to exercise after spending time sedentary, such as when recovering from an illness.

Healthcare professionals will also rule out whether you’re experiencing pain-related movement problems with usual muscle strength, rather than true muscle weakness.

If they rule out these factors, they may test your muscle strength using an objective tool called the Medical Research Council Muscle Scale. Depending on the results, they may recommend further diagnostic tests.

Everyone begins to lose muscle mass and strength as they get older, starting as early as age 30 years. This is a typical bodily process.

Muscle strength reduces more quickly in some people, known as sarcopenia. This affects an estimated 10% to 20% of older adults.

Symptoms of sarcopenia include:

  • muscle weakness
  • falling
  • walking slowly 
  • perceived muscle wasting 
  • having difficulty doing usual daily tasks

Getting more exercise, especially strength training, and following a protein-rich diet can help with these symptoms.

3. Vitamin and mineral deficiencies

Some vitamin deficiencies and mineral deficiencies can cause muscle weakness.

For example, a 2018 case study reports that vitamin D deficiency can lead to proximal muscle weakness, which means weakness near the center of the body, and an increased risk of falls.

Other vitamin deficiencies linked with muscle weakness include:

If you suspect a vitamin deficiency, consider asking a doctor for blood tests. Taking vitamin supplements is a common and effective treatment option.

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4. Chronic fatigue syndrome

People with CFS — also known as myalgic encephalomyelitis (ME) or ME/CFS — experience extreme fatigue after small amounts of activity. The US Institute of Medicine published a report in 2015 renaming CFS as systemic exertion intolerance disease (SEID). Therefore, some institutions refer to the condition as SEID.

The Centers for Disease Control and Prevention (CDC) report that up to 2.5 million people in America may have CFS.

This fatigue may feel like muscle weakness, though the muscles themselves haven’t lost strength. People with CFS may have difficulty maintaining muscle tone as they aren’t able to do as much physical activity.

Research from 2016 says there is increasing evidence that abnormalities in the muscle’s biochemistry, such as acid buildup, may play a major role in fatigue associated with CFS.

Other symptoms of CFS include:

  • difficulty sleeping
  • problems with thinking and memory
  • symptoms worsening when standing or sitting up
  • pain, such as muscle aches, headaches, or joint pain
  • a sore throat
  • digestive issues, including irritable bowel syndrome

There’s no specific treatment for CFS, but over-the-counter painkillers, healthy sleep habits or sleep medication, and mental health treatments can help.

5. Multiple sclerosis

MS is an autoimmune condition where your body attacks healthy nerve fibers. Nearly 1 million people in the United States live with MS.

Muscle weakness is a common symptom of MS. This may be because you’re moving around less due to pain and fatigue, which means your muscles lose strength. It could also result from damage to the nerve fibers in the spinal cord or brain.

You may feel muscle weakness all over your body or specific body parts, including the arms, hands, legs, feet, facial muscles, and muscles that help you talk or swallow. It can also affect bladder control.

Other symptoms of MS include:

  • tingling
  • numbness
  • memory problems
  • mood changes
  • fatigue
  • pain

Treatment for MS aims to slow the disease course and prevent symptom relapse. A doctor may prescribe medications and rehabilitation methods. 

6. Hormonal causes

Various hormonal conditions can cause muscle weakness, including:

Diabetes is another hormonal condition that can affect your muscles. Diabetic neuropathy may affect the nerves that control movement, leading to muscle weakness. If you have diabetes, taking diabetes medication can help with symptoms and complications.

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7. Neurological conditions

Conditions that affect your brain or brain — known as neurological conditions — can also affect your muscle strength.

Muscle weakness on one side of the body is more common in brain-related conditions, such as a stroke.

Muscle weakness with pain is more common in nerve-related conditions (neuropathy), such as a pinched nerve. For example, a pinched nerve in your spine can cause muscle weakness in your legs, and carpal tunnel syndrome can cause weakness in your hands.

Rare neurologic causes of muscle weakness include:

  • amyotrophic lateral sclerosis, a rare progressive disease that damages your nerves
  • Guillian-Barré syndrome, a rare condition where your immune system attacks your nerves
  • motor neuropathy, a condition that develops in adulthood and causes asymmetric muscle weakness, typically in the upper limbs
  • myasthenia gravis, a neuromuscular disorder that causes muscle weakness across the body, including the eyes, throat, arms, and legs

8. Alcohol and other substances

Excessive alcohol use can lead to muscle weakness, particularly in those who drink in excess. Alcohol is toxic to the nerves and muscles. 

Other recreational substances can also lead to muscle weakness, including:

  • cocaine
  • amphetamines 
  • opioids

Treatment for substance use disorders can include detox programs, medications, and therapies.

9. Medication side effects

Various medications can cause muscle weakness as a side effect, including:

If you think your medication may be causing muscle weakness or other undesirable symptoms, consider talking with a doctor about adjusting your medications.

10. COVID-19 infection

Early research, including a 2022 review, suggests that mild, moderate, and severe COVID-19 can cause muscle and skeleton symptoms as well as affect your respiratory system.

Many people experience musculoskeletal symptoms for months after having COVID-19. This is known as long COVID. Symptoms of long COVID can include:

  • fatigue
  • muscle aches
  • joint pain
  • muscle weakness

The researchers say more research is needed — especially muscle imaging and analysis of muscle tissue — to determine how COVID-19 affects the muscles. Possible causes include inflammation, muscle disease, or another disorder directly or indirectly related to COVID-19.

When to talk with a doctor

If you’re unsure what’s causing your muscle weakness, consider talking with a doctor.

They may ask questions about what body parts are affected, your medical history, and other symptoms to determine the cause and suggest the best treatments.


Muscle weakness has a vast range of possible causes, including:

  • muscle fatigue after exercise
  • age-related muscle weakness
  • vitamin deficiencies
  • hormonal causes
  • chronic conditions, like MS and CFS
  • neurological conditions
  • alcohol use
  • a side effect of medications
  • long COVID

The most appropriate treatment differs depending on the cause. A healthcare professional may recommend medication, therapies, or lifestyle strategies to help with your symptoms.

If you need help covering the cost of medications, Optum Perks’ free Discount Card could help you get up to 80% off prescription medication. See how much you can save on your medication here.

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