Methocarbamol oral tablet interactions: A detailed guide

This article describes possible interactions with methocarbamol oral tablet. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.

To find coupon options for methocarbamol and to learn more about the drug, including its uses, see this article.

Methocarbamol is also available as a solution that’s injected into your vein or muscle. Interactions of methocarbamol may vary depending on the form of methocarbamol you’re prescribed.

Other drugs and methocarbamol

Drugs that may interact with methocarbamol oral tablet are listed below. This article doesn’t include all drugs that may interact with methocarbamol.

Drugs that may interact with methocarbamol oral tablet include:

• opioids:
  • drug examples: morphine (MS Contin, others), oxycodone (Roxicodone, others)
  • what might happen: can cause severe central nervous system (CNS) depression, leading to symptoms such as severe sleepiness
• benzodiazepines:
  • drug examples: alprazolam (Xanax), clonazepam (Klonopin)
  • what might happen: can cause severe CNS depression, leading to symptoms such as severe sleepiness
• cholinesterase inhibitors:
  • drug examples: rivastigmine (Exelon), pyridostigmine (Mestinon, Regonol)
  • what might happen: can make cholinesterase inhibitors less effective
• synthetic cannabinoids:*
  • drug examples: dronabinol (Marinol, Syndros), nabilone (Cesamet)
  • what might happen: can increase the risk of respiratory depression (slow, shallow breathing)
• certain antipsychotics:
  • drug examples: clozapine (Clozaril, Versacloz), chlorpromazine
  • what might happen: can increase the risk of CNS depression and side effects such as sleepiness and respiratory depression (slow, shallow breathing)
• promethazine (Promethegan):
  • what might happen: can increase the risk of CNS depression and side effects such as sleepiness
• gabapentin (Neurontin, others):
  • what might happen: can cause severe CNS depression, leading to symptoms such as severe sleepiness
• deutetrabenazine (Austedo, Austedo XR):
  • what might happen: can increase the risk of CNS depression and side effects such as sleepiness
• baclofen (Lyvispah, others)
  • what might happen: can increase the risk of CNS depression and side effects such as sleepiness

* For details about the interaction between methocarbamol and cannabis products, see the “Other interactions and methocarbamol” section below.

Health factors and methocarbamol

Certain medical conditions or other health factors may increase the risk of interactions with methocarbamol oral tablet. Before taking methocarbamol, tell your doctor about your health history. They’ll determine whether methocarbamol is right for you and explain any methocarbamol warnings.

Here’s a list of health conditions or other factors that might interact with methocarbamol oral tablet:

• kidney conditions, such as chronic kidney disease
• pregnancy or breastfeeding
• past allergic reaction to methocarbamol

When to avoid methocarbamol

Certain health conditions or other factors could increase some risks with methocarbamol oral tablet. Because of this, doctors may not prescribe methocarbamol in these cases. These health conditions or other factors are called contraindications.

Here’s a contraindication for methocarbamol oral tablet:

• Past allergic reaction to methocarbamol. If you’ve had an allergic reaction to methocarbamol oral tablet in the past, taking methocarbamol may cause an allergic reaction.

Before starting treatment with methocarbamol, tell your doctor if the above relates to you. They can recommend whether you should take methocarbamol.

Alcohol and methocarbamol

Methocarbamol oral tablet is known to interact with alcohol. Your doctor will likely recommend that you avoid drinking alcohol while taking methocarbamol.

Taking methocarbamol oral tablet and drinking alcohol may cause severe central nervous system depression. Symptoms can include:

• poor judgment
• severe problems with balance and coordination
• slurred speech
• drowsiness or fainting

Drinking alcohol while taking methocarbamol also raises the risk of a methocarbamol overdose. This can be life threatening in rare cases. Symptoms can include nausea, drowsiness, blurred vision, low blood pressure, seizures, and coma.

If you drink alcohol and have concerns about avoiding it during methocarbamol oral tablet treatment, talk with your doctor.

Other interactions and methocarbamol

Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether methocarbamol oral tablet has these interactions.

The information below doesn’t include all other possible interactions with methocarbamol.

Methocarbamol and supplements

Before taking methocarbamol oral tablet, tell your doctor and pharmacist about any supplements, herbs, and vitamins you take. Doing so may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Methocarbamol interactions with herbs

Methocarbamol oral tablet isn’t known to interact with herbs. But this doesn’t mean interactions with herbs can’t happen or won’t be identified later.

Because of this, you should ask your doctor or pharmacist before taking any of these products during treatment with methocarbamol oral tablet.

Methocarbamol interactions with vitamins

Methocarbamol oral tablet isn’t known to interact with vitamins. But this doesn’t mean interactions with vitamins can’t happen or won’t be identified later.

Because of this, you should ask your doctor or pharmacist before taking any of these products during treatment with methocarbamol oral tablet.

Methocarbamol and food

Methocarbamol oral tablet isn’t known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist about foods you should avoid during treatment with methocarbamol oral tablet.

Methocarbamol and vaccines

Methocarbamol oral tablet isn’t known to interact with vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.

Because of this, you should talk with your doctor or pharmacist before receiving any vaccines during treatment with methocarbamol oral tablet.

Methocarbamol and lab tests

Methocarbamol oral tablet may interact with certain urine tests to check 5-hydroxyindoleacetic acid (5-HIAA) or urinary vanillylmandelic acid (VMA). These tests are used to check for certain tumors.

Taking methocarbamol and having these tests may lead to inaccurate test results. Your doctor can suggest other tests instead that won’t interfere with methocarbamol.

Methocarbamol and cannabis or CBD

Reports have shown cannabis (commonly called marijuana) and cannabis products may interact with methocarbamol. Cannabidiol (CBD) is an example of a cannabis product.

Taking methocarbamol and cannabis or cannabis products may lead to severe central nervous system depression. Symptoms can include respiratory depression (slow, shallow breathing), lack of coordination, and poor judgment.

Before you take methocarbamol, tell your doctor and pharmacist if you use cannabis. Doing so may help prevent possible interactions.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Preventing methocarbamol interactions

You may be able to help avoid certain interactions with methocarbamol oral tablet. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.

Things to consider include:

• Whether you drink alcohol or use cannabis.
• Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a medication list.
• What to do if you’re prescribed a new drug during your methocarbamol oral tablet treatment.

Taking methocarbamol exactly as prescribed can also help prevent interactions.

What to ask your doctor

If you have questions about methocarbamol and possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

• Do other medications that can treat my condition have similar interactions as methocarbamol?
• If I drive or operate machinery as part of my job, is it safe to take methocarbamol?
• Should I tell you if I start taking another medication or supplement while taking methocarbamol?
• Can I still take methocarbamol even if it interacts with my other medication?

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.