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Knee injections for pain and arthritis

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When are they used?TypesSide effectsSummary
Arthritis happens when the cartilage in your joints wears down and exposes your bones to friction. Injections into the joints can reduce the pain that arthritis may cause.
Medically reviewed by Stella Bard, MD
Updated on

Cartilage is the connective tissue that cushions your joints. When the cartilage wears away, it exposes the bones to each other. Arthritis can result from the natural wear and tear of the cartilage, and it can cause joint pain and swelling. Certain autoimmune conditions may speed up the loss of cartilage.

Exercising, taking arthritis medications, and maintaining a moderate weight can help reduce arthritis symptoms. But if these strategies are not helping you manage your condition, knee injections may be a treatment option.

When to consider knee injections

An image of an adult sitting on a couch holding their knee.
Photography by AsiaVision / Getty Images

Knee arthritis can happen for no apparent reason, without an underlying condition. It can also result from autoimmune factors, such as in rheumatoid arthritis.

Knee osteoarthritis is a degenerative condition that involves the cartilage of your knee joint.

This condition can gradually speed up the natural wear and tear of the cartilage, causing pain in your knee and making its movement more difficult. Osteoarthritis is also characterized by swelling and inflammation of the joint that can increase with exercise.

When lifestyle strategies, like eating a balanced diet and getting more exercise, are not helping you manage your condition, a healthcare professional may recommend knee injections to reduce pain and swelling.

If you suspect you have knee osteoarthritis or you experience constant pain in your knee, consider talking with a healthcare professional. They can perform a physical examination and recommend imaging tests to diagnose the reason for your discomfort.

Based on their diagnosis, they can work with you to figure out the most effective treatments.

Types of injections

Healthcare professionals may recommend injections to people with arthritis in order to help reduce pain in their joints. Many types of injections are available, and a healthcare professional can recommend the treatment that may be most effective for your condition.


Corticosteroid injections, such as hydrocortisone, can be used to treat swollen joints.

This medication can also help treat bursitis and tendinitis. Bursitis is inflammation of a fluid-filled sac, called a bursa, that helps cushion a joint. Tendinitis is inflammation of the tendons, which are tissues that connect muscles to bones.

When used in the joint, corticosteroid injections reduce swelling and pain. Afterward, your knee may feel better for several months and sometimes up to a year.

However, you may need to receive more injections. A person can receive up to 4 injections in a 12-month period.

A single dose of the steroid injection may range from 5 to 50 milligrams (mg), depending on the size of the joint and how well the previous injection worked.

Receiving corticosteroid injections can reduce how well your immune system works, which makes you more likely to experience severe symptoms from an infection. That’s why it’s important to contact a healthcare professional if you develop any infection, including COVID-19 or chickenpox.

And though these medications are typically very effective, they may not be suitable for everyone. For example, people who have bipolar disorder, are pregnant, or have an infection cannot receive hydrocortisone.

Aside from hydrocortisone, corticosteroid medications may include:

Betamethasone sodium phosphate and acetate0.25–2 milliliters (mL)
Dexamethasone acetate8 mg
Dexamethasone sodium8 mg
Methylprednisolone acetate20–80 mg
Triamcinolone acetonide10–40 mg
Triamcinolone hexacetonide10–20 mg

Hyaluronic acid

Hyaluronic acid is a natural substance found in tendons, joints, and bones. Hyaluronic acid injections into the knee may help reduce inflammation and improve the lubrication of the joint.

Hyaluronic acid injections can help reduce pain in your knee 8–24 weeks after the injection.

Platelet-rich plasma (PRP) injection

PRP injections are widely used to treat arthritis of the knee. A 2022 study found that PRP treatment can have greater benefits than hyaluronic acid injections. PRP can reduce long-term discomfort caused by arthritis and may be more effective at keeping the joint working properly.

People receiving PRP injections in the study reported a reduction in pain after the first month of treatment. The researchers saw the best results of the treatment after about 6 months.

Stem cell injection

Stem cell injections may improve arthritis. It may take 24–72 weeks before you notice a reduction in your symptoms and improvement in the volume of the knee cartilage, according to a 2021 review.

Stem cells can help repair tissues, and these new treatment techniques may have promise for the future. However, more research is needed.

Polyacrylamide hydrogel injection

Scientists are currently developing new compounds that can be injected into the joints to improve arthritis without resulting in any particular side effects.

Polyacrylamide hydrogel is one of these new compounds. This is made from water molecules attached to a polyacrylamide backbone. This means the compound won’t break down when injected into a joint. The product is intended to offer lubrication to the joint and reduce inflammation.

However, more research is needed to further develop these new types of treatment.

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Possible side effects

Knee injections may have different side effects, depending on the type of medications injected into the joint.

The following table will review the possible negative effects that you may experience if you undergo arthritis treatment and receive an injection in your knee.

Type of injectionSide effects
corticosteroidsCommon side effects can include:

• intense pain and swelling at the injection site
bruising at the injection site

You should contact a healthcare professional immediately if you experience any of the following:

• feelings of depression, anxiety, or suicidal thoughts
• a high temperature or chills
• very sore throat or any other signs of infection
• changes in sight
• swelling in arms, legs, abdomen, or face
• difficulty breathing
• chest pain
• a feeling of confusion or sleepiness
• a need to urinate very frequently
hyaluronic acidAt the injection site, you may experience:

• pain
• bruising
• redness or discoloration
• swelling

These side effects do not typically last for more than a week.
PRP injectionYou might experience:

• formation of scar tissue at the injection site
• calcification at the injection site
• infection or injury of blood vessels and nerves near the injection site (though this is rare)
stem cell injectionThis may cause infection in people who are immunocompromised. However, more research is needed.
polyacrylamide hydrogel injectionThere isn’t a lot of research on side effects of these injections, but one older 2014 study mentioned that some people experienced burning pain or swelling of the joint.


Arthritis can cause inflammation in the joints of your knees. This can result in swelling and pain. A healthcare professional may suggest that you receive one or more injections in your knee joint if other therapies have not helped your condition.

Many types of injectable medications are available for treating knee arthritis. These include corticosteroids, hyaluronic acid, and PRP injections. However, some types of drugs may not work if someone with arthritis also has certain other health conditions.

A healthcare professional can recommend the most effective treatment for your knee arthritis.

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