Skip to main content
Medically Approved

Lisinopril: Beta-blocker or ACE inhibitor?

twitter share buttonfacebook share buttonlinkedin share buttonemail article button
OverviewACE inhibitors vs. beta-blockersBeta blocker medsACE inhibitor medsTaking them togetherLisinopril alternativesSummary
Lisinopril belongs to the drug class known as angiotensin converting enzyme (ACE) inhibitors. Doctors prescribe lisinopril to manage high blood pressure and, in critical cases, to increase your chances of surviving a heart attack or protecting your kidneys.
Medically reviewed by Monica Kean, PharmD
Written by Rashida Ruwa, RN
Updated on

—————-

Need a diagnosis or prescription quickly? Optum Perks offers personalized on-demand care in as little as 15 minutes. For $29, answer a few questions online and receive a diagnosis and treatment plan from a US-licensed healthcare professional. Get started here.

Man on phone in bed

100% online care

Treatment plans in 15 minutes or less for 40+ conditions.

Start consult now

Overview

Lisinopril is not a beta-blocker or a blood thinner but rather an ACE inhibitor. It works by relaxing blood vessels, which helps lower blood pressure and improve the heart’s ability to pump blood.

You can find generic lisinopril under various brand names in the United States, including:

Healthcare professionals commonly prescribe lisinopril to treat high blood pressure (hypertension) and to manage heart failure. It may also help protect the kidneys in people with diabetes.

Consulting with a healthcare professional if you experience any unusual or severe side effects while taking this medication is highly encouraged.

What is the difference between ACE inhibitors and beta-blockers?

Woman taking ACE inhibitor lisinopril with a glass of water
Photography by Maskot/Getty Images

ACE inhibitors, such as lisinopril, and beta-blockers are two different classes of medications commonly used to treat various cardiovascular conditions, including hypertension. 

ACE inhibitors work by blocking the effects of an angiotensin-converting enzyme. By inhibiting ACE, blood vessels are relaxed and widened, leading to decreased blood pressure and improved blood flow.

Beta-blockers work by blocking the beta-adrenergic cell receptors in the heart, kidneys, and fat cells, which helps reduce the effects of stress hormones such as adrenaline. This slows down the heart rate and reduces the force of contractions, which results in lowered blood pressure.

Healthcare professionals may prescribe lisinopril and other ACE inhibitors to treat various conditions, including:

  • hypertension
  • heart failure
  • diabetic nephropathy
  • chronic kidney disease
  • left ventricular dysfunction

They may prescribe beta-blockers to treat several conditions, including:

  • angina (chest pain)
  • hypertension
  • arrhythmias (irregular heartbeats)
  • certain heart rhythm disorders

Common side effects of ACE inhibitors may include:

  • dizziness
  • headache
  • fatigue (low energy)
  • dry cough
  • gastrointestinal symptoms

Possible side effects of beta-blockers may include:

  • fatigue
  • cold hands and feet
  • slow heartbeat
  • dizziness

ACE inhibitors are commonly long-term treatments. Medical professionals often prescribe them for extended periods to manage blood pressure and improve heart function.

Beta-blockers may be both a short-term and long-term treatment. Professionals may prescribe them for acute or temporary symptoms, such as anxiety-related hypertension or rapid heart rate. They may also prescribe them for long-term management of chronic conditions such as hypertension or heart rhythm disorders.

The choice between ACE inhibitors and beta-blockers depends on several factors, including the specific cardiovascular condition being treated and any other underlying medical conditions.

Common beta-blockers

Common beta-blockers may include:

Common ACE inhibitors

Commonly prescribed ACE inhibitors may include:

Need a refill for lisinopril (Zestril)? You may be able to get an online prescription through Optum Perks in as little as 15 minutes. Learn more here.

Man on phone in bed

100% online care

Treatment plans in 15 minutes or less for 40+ conditions.

Start consult now

Can you take ACE inhibitors and beta-blockers together?

Yes, you can take ACE inhibitors and beta-blockers together if your healthcare professional sees the need.

Your healthcare professional may prescribe them together if you live with certain heart conditions, such as heart failure, or if you’ve had a recent heart attack. 

Combining these medications may provide complementary benefits in managing blood pressure, heart function, and cardiovascular health. Still, you should do this only under your doctor’s guidance and supervision.

What are the recommended lisinopril alternatives?

If you do not tolerate lisinopril or experience adverse side effects with ACE inhibitors and beta-blockers, your healthcare professional may recommend other medications, including:

  • Angiotensin II receptor blockers (ARBs): Medications, such as losartan (Cozaar), valsartan (Diovan), or irbesartan (Avapro), work similarly to ACE inhibitors in managing blood pressure and some people may tolerate them better.
  • Calcium channel blockers: Medications, such as amlodipine (Norvasc) or diltiazem (Cardizem), may effectively lower blood pressure and may be suitable alternatives.
  • Thiazide diuretics: Hydrochlorothiazide (Microzide) is a type of diuretic that you can take alone or in combination with other medications to manage hypertension.

If you need help covering the cost of medications, the free Optum Perks Discount Card could help you save up to 80% on prescription drugs. Follow the links on drug names for savings on that medication, or search for a specific drug here.

Pill bottle with text 'Starts at $4'

Free prescription coupons

Seriously … free. Explore prices that beat the competition 70% of the time.

Get free card

Summary

Lisinopril is not a beta-blocker but rather an ACE inhibitor, which works by relaxing blood vessels and reducing blood pressure.

While beta-blockers and ACE inhibitors play essential roles in managing cardiovascular health, they have distinct mechanisms of action, and healthcare professionals prescribe them for different reasons.

You may also take them together in some cases.

Consider talking with a healthcare professional for personalized guidance on medication choices and their effects on your health.

Related articles

Article resources