This article describes warnings of possible interactions with hyoscyamine sublingual tablet. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.
Hyoscyamine also comes as a tablet, capsule, or liquid that you swallow.
Note: The Food and Drug Administration (FDA) has not approved hyoscyamine. This is because the drug has been available since before the FDA began its drug approval process. If you have questions about this, talk with your doctor or pharmacist.
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Other drugs and hyoscyamine
The drugs in the list below may interact with hyoscyamine sublingual tablet. This article doesn’t include all drugs that may interact with hyoscyamine.
Drug classes or drugs that may interact with hyoscyamine sublingual tablet include:
- antacids:
- drug examples: aluminum hydroxide/magnesium carbonate (Gaviscon) and calcium carbonate/magnesium hydroxide (Rolaids)
- what might happen: can make hyoscyamine less effective
- certain antidepressants
- certain antipsychotic drugs
- drug example: haloperidol and clozapine (Clozaril)
- what might happen: can increase the risk of side effects
- IBS-D (irritable bowel syndrome with diarrhea) drugs:
- drug examples: eluxadoline (Viberzi) and alosetron (Lotronex)
- what might happen: can increase the effect of these drugs
- inhaled anticholinergics:
- drug example: tiotropium (Spiriva)
- what might happen: can increase the risk of side effects
- myasthenia gravis medications:
- drug example: pyridostigmine (Mestinon)
- what might happen: can make hyoscyamine less effective
- amantadine:
- what might happen: can increase the risk of side effects
- pramlintide (Symlin):
- what might happen: can increase the effect of pramlintide
- quinidine:
- what might happen: can increase the risk of quinidine toxicity
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When to avoid hyoscyamine
Certain health conditions or other factors could increase some risks with hyoscyamine sublingual tablet. Because of this, doctors may not prescribe hyoscyamine in these cases. These health conditions or other factors are called contraindications.
Here’s a list of contraindications for hyoscyamine sublingual tablet:
- Glaucoma: If you have glaucoma, taking hyoscyamine sublingual tablet may make it worse.
- Heart problems: If you have a heart problem, taking hyoscyamine sublingual tablet may make it worse.
- Intestinal blockage: If you have an intestinal blockage, taking hyoscyamine sublingual tablet may make it worse.
- Myasthenia gravis: If you have myasthenia gravis, taking hyoscyamine sublingual tablet may make it worse.
- Severe ulcerative colitis: If you have severe ulcerative colitis, taking hyoscyamine sublingual tablet may cause serious complications.
- Urinary blockage: If you have urinary blockage, including an enlarged prostate gland, taking hyoscyamine sublingual tablet may make it worse.
- Past allergic reaction to hyoscyamine: If you’ve ever had an allergic reaction to hyoscyamine sublingual tablet, taking it again may cause a life threatening allergic reaction.
Before you start taking hyoscyamine, tell your doctor if anything listed above relates to you. They can recommend whether you should take hyoscyamine.
Alcohol and hyoscyamine
Hyoscyamine sublingual tablet is known to interact with alcohol.
Taking hyoscyamine sublingual tablet and drinking alcohol may cause increased side effects such as:
- dizziness
- drowsiness
- mental confusion
If you drink alcohol, talk with your doctor about whether it’s safe to consume it while taking hyoscyamine sublingual tablet.
Other interactions and hyoscyamine
Interactions can occur with supplements, foods, vaccines, and some lab tests. Below, you can learn whether the hyoscyamine sublingual tablet has these interactions.
The information below doesn’t include all other possible interactions with hyoscyamine.
Hyoscyamine and supplements
Before taking hyoscyamine sublingual tablet, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.
Hyoscyamine sublingual tablet may interact with potassium supplements. This supplement is often used for low potassium levels and muscle health. Potassium is also a common ingredient in salt substitutes.
Taking hyoscyamine and potassium may injure the lining of the digestive tract.
Hyoscyamine sublingual tablet may also interact with calcium supplements. This supplement is often used for building and maintaining strong bones.
Taking hyoscyamine and calcium may reduce how well hyoscyamine works in your body.
Because of this, ask your doctor or pharmacist before taking any supplements while taking hyoscyamine sublingual tablet.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Hyoscyamine interactions with herbs
Hyoscyamine sublingual tablet isn’t known to interact with any herbs. But this doesn’t mean interactions with herbs can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before taking any herbs while taking hyoscyamine sublingual tablet.
Hyoscyamine interactions with vitamins
Hyoscyamine sublingual tablet isn’t known to interact with any vitamins. But this doesn’t mean interactions with vitamins can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before taking any vitamins while taking hyoscyamine sublingual tablet.
Hyoscyamine and food
Hyoscyamine sublingual tablet isn’t known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist about what foods you should avoid while taking hyoscyamine sublingual tablet.
Hyoscyamine and vaccines
Hyoscyamine sublingual tablet isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before receiving any vaccines while taking hyoscyamine sublingual tablet.
Hyoscyamine and lab tests
Hyoscyamine sublingual tablet may interact with a test used to check the ability of the pancreas to respond to a hormone called secretin. It also may interact with a test that checks for adult growth hormone deficiency.
Taking hyoscyamine and having these tests may lead to a false result.
Because of this, talk with your doctor or pharmacist before having any lab tests while taking hyoscyamine sublingual tablet.
Hyoscyamine and cannabis or CBD
Hyoscyamine sublingual tablet isn’t known to interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But this doesn’t mean interactions can’t happen or won’t be identified later.
As with any drug or supplement, tell your doctor before taking cannabis with hyoscyamine.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Health factors and hyoscyamine
Certain medical conditions or other health factors may increase the risk of interactions with hyoscyamine sublingual tablet. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking hyoscyamine, tell your doctor about your health history. They’ll determine whether hyoscyamine is right for you.
These health conditions or other factors might interact with hyoscyamine sublingual tablet:
Questions about hyoscyamine and interactions
Can you take hyoscyamine and omeprazole together?
Probably. There are no reports of interactions between hyoscyamine and omeprazole in the prescribing information for hyoscyamine sublingual tablet.
If you have more questions about taking hyoscyamine and omeprazole together for digestive problems, talk with your doctor.
Can you take hyoscyamine and an opioid together?
It’s possible. But opioids, such as oxycodone (Roxybond) and morphine sulfate (MS Contin), can interact with hyoscyamine sublingual tablet.
If you take opioids with hyoscyamine sublingual tablet, it can increase the risk of constipation and urinary or intestinal blockages. Your doctor will likely monitor you more closely if they prescribe both an opioid and hyoscyamine.
If you have more questions about taking an opioid and hyoscyamine sublingual tablet together, talk with your doctor.
Preventing hyoscyamine interactions
You may be able to help avoid certain interactions with hyoscyamine sublingual tablet. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.
Things to consider include:
- Whether you drink alcohol or use cannabis.
- Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
- What to do if you’re prescribed a new drug while taking hyoscyamine sublingual tablet.
Taking hyoscyamine exactly as prescribed can also help prevent interactions.
What to ask your doctor
If you have questions about hyoscyamine and possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Can I take hyoscyamine sublingual tablet even if it interacts with a health condition I have?
- Do other drugs that could treat my condition have similar interactions?
- Should I tell you if I start taking another medication or supplement during my hyoscyamine treatment?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
