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How long does tramadol take to work?

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Are the effects immediate?How long does it last?Other optionsSummary
Tramadol is a medication that doctors and healthcare professionals may prescribe to help treat moderate to severe pain. It starts working within 1 hour and provides relief for about 4–6 hours.
Medically reviewed by Alyssa Peckham, PharmD, BCPP
Written by Rashida Ruwa, RN
Updated on

Tramadol is a pain medication that belongs to the drug class of opioids, specifically narcotic analgesics. It is available under various brands, including Conzip and Qdolo.

Healthcare professionals prescribe tramadol to treat moderate to severe pain. It works by binding to opioid receptors, interrupting how your brain interprets pain.

It is important to note that tramadol is a controlled substance. This means you should only use it as directed by a doctor or healthcare professional.

Does tramadol work immediately?

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While tramadol (Conzip, Qdolo) provides effective pain relief, it may not work immediately. How long it takes can vary from person to person, and it typically takes about 1 hour for the medication to start working. However, many factors can affect this timeframe, like:

  • dosage
  • individual metabolism
  • organ function
  • age

If you’re experiencing severe pain or need faster pain relief, a doctor or healthcare professional may prescribe a different medication or recommend alternative pain management strategies. 

How long does tramadol stay in your system?

On average, tramadol has a half-life of around 6 hours. This means that it takes your body about 6 hours to eliminate half of the drug. With this half-life, it typically takes up to 48 hours for your body to clear most of the drug.

The effectiveness of tramadol varies depending on the person. Typically, tramadol’s pain-relieving effects last about 4–6 hours. However, extended-release versions of tramadol can provide longer-lasting pain relief.

How much tramadol can you take within 24 hours?

The appropriate tramadol dosage within 24 hours depends on several factors, such as:

  • pain severity
  • individual tolerance
  • the specific formulation

For immediate-release tramadol, the starting dosage for adults is typically 25 milligrams (mg) four times each day, with or without food, as needed for pain relief.

However, a healthcare professional may adjust the dosage based on your response to the medication and other factors. Dosages can increase to a maximum daily dose of 100 mg four times each day. You should not exceed 400 mg in 24 hours.

However, tramadol carries risks of dependence and addiction, particularly when taken in higher doses or for a longer period. Regular or excessive use of tramadol may lead to misuse or dependence.

This is why it is important to use tramadol strictly as prescribed and talk openly with a doctor or healthcare professional about any concerns or changes in your pain management.

Other pain management options

There are several pain management medications, both opioid and non-opioid.

Nonopioid pain relievers

Commonly prescribed non-opioid alternatives include:

  • Acetaminophen (Tylenol): Acetaminophen (Tylenol) is a non-opioid analgesic doctors and healthcare professionals commonly use for mild to moderate pain relief. It is available over the counter (OTC) and in prescription-strength formulations. Acetaminophen reduces pain and fever but does not have significant anti-inflammatory effects.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs): A healthcare team may suggest or prescribe NSAIDs like ibuprofen (Advil) and naproxen (Aleve) to relieve pain, inflammation, and fever. Although NSAIDs are available OTC and in prescription strengths, they may not suit everyone, and you should use them cautiously — particularly if you have medical conditions like gastrointestinal or cardiovascular conditions.
  • Gabapentin (Neurontin): Gabapentin (Neurontin) is an anticonvulsant medication that healthcare professionals use to treat certain pain types, including nerve pain (neuropathic pain). It is effective for conditions such as diabetic neuropathy and postherpetic neuralgia. Other medications in the same class include pregabalin (Lyrica).

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Opioid pain relievers

Healthcare professionals may prescribe opioids for moderate to severe pain management. However, while they provide strong pain relief, they also carry the risk of dependence.

Common opioid alternatives to tramadol include:

  • Hydrocodone (Lortab): Healthcare professionals commonly prescribe hydrocodone (Lortab) for chronic, severe pain. You can combine hydrocodone with acetaminophen or ibuprofen to enhance its effectiveness, and it is available in various strengths and formulations.
  • Oxycodone (Roxicodone): Healthcare professionals prescribe oxycodone (Roxicodone) for moderate to severe pain. It is available in immediate-release and extended-release formulations. Similar to tramadol, you can combine oxycodone with aspirin, acetaminophen, or ibuprofen in certain formulations.
  • Morphine (MS Contin): Morphine (MS Contin) is a strong opioid agonist that healthcare professionals commonly use for acute and chronic pain. It is available in multiple formulations, including immediate-release and extended-release forms. In addition to oral tablets, healthcare professionals can administer morphine in injectable or transdermal preparations.

All medications come with potential risks and side effects. Consider speaking with a healthcare team so they can evaluate your condition and determine the most appropriate alternative to tramadol.

Summary

Tramadol is an effective pain medication that works by binding to opioid receptors in the brain. It is a controlled substance due to its habit-forming nature and risk of misuse.

The effects of tramadol typically take around 1 hour to start working and last for around 4–6 hours. However, extended-release formulations can provide longer-lasting pain relief. 

You should only take tramadol as a healthcare professional directs. If tramadol does not work well for you, they may recommend an alternative medication or pain management strategies for faster, more effective pain relief. 

Download the free Optum Perks Discount Card to save up to 80% on some prescription medications.

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