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Tamiflu: How long does it take to work?

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How long?How does it work?Who is it for?AlternativesHow to get Tamiflu
Tamiflu works best when taken within 48 hours of symptoms. Early treatment can increase its efficacy and prevent complications. Taking it outside of the 48-hour symptom window may prove ineffective.
Medically reviewed by Alyssa Walton, PharmD
Written by Rashida Ruwa, RN
Updated on

Tamiflu, also known by its generic name oseltamivir, is a widely prescribed antiviral medication for treating influenza (the flu). Its effectiveness depends on prompt administration, typically within 48 hours of symptoms, especially for those at greater risk of complications.

Oseltamivir (Tamiflu) inhibits the influenza virus’s neuraminidase enzyme, limiting viral spread and alleviating symptoms. Pregnant people, young children, older adults, and those with underlying chronic health conditions may benefit most from it.

If you suspect you have the flu and want to consider Tamiflu as part of your treatment plan, consider talking with a healthcare professional.

How long does it take for Tamiflu to work?

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Oseltamivir (Tamiflu) typically starts working within a few hours when you take it within 48 hours of feeling flu symptoms. It can work before the 48-hour window in severe cases or for people at risk of complications. However, its effectiveness can vary depending on the flu strain and the optimal treatment time. 

Taking oseltamivir (Tamiflu) early is important to maximize its benefits and reduce the duration and severity of the condition. However, Tamiflu may not be effective if you take it after the 48-hour window of experiencing flu symptoms.

How does Tamiflu work?

Oseltamivir (Tamiflu) works by inhibiting a flu virus enzyme called the neuraminidase. Neuraminidase is an enzyme necessary for releasing the flu virus from infected cells and spreading the virus around the body. 

The medication prevents the release of any new viral particles from the cells and slows down infection progression.

By inhibiting neuraminidase, oseltamivir (Tamiflu) helps reduce the severity and duration of flu symptoms.

Oseltamivir phosphate is a prodrug, meaning it is an inactive compound that becomes active after you take or receive the medication. Tamiflu’s active metabolite is oseltamivir carboxylate, which inhibits the neuraminidase enzyme.

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Who is Tamiflu good for?

Oseltamivir (Tamiflu) is good for people diagnosed with the flu, who have been experiencing symptoms for no longer than 48 hours. It is particularly beneficial for those at higher risk of complications from the flu, including:

  • pregnant people
  • children under 2 years old 
  • older adults (over 65 years)
  • people with weakened immune systems due to disease or medications, such as those on chemotherapy 
  • people with chronic medical conditions, such as heart disease, asthma, and diabetes

If you fall into any of these categories and are experiencing flu symptoms, consider talking with a healthcare professional to determine if Tamiflu is appropriate.

Are there any Tamiflu alternatives?

While oseltamivir (Tamiflu) is the most commonly prescribed antiviral medication for treating the flu, there are a few alternatives available, including:

  • Zanamivir (Relenza): Zanamivir (Relenza) is a neuraminidase inhibitor, similar to Tamiflu. It is administered via inhaler and is approved to treat the flu in people ages 7 years and above. Healthcare professionals may also prescribe it to prevent the flu.
  • Peramivir (Rapivab): Peramivir (Rapivab) is an intravenous (IV) neuraminidase inhibitor approved for treating acute uncomplicated flu in infants ages 6 months and older and adults with flu symptoms for no more than 48 hours. 
  • Baloxavir marboxil (Xofluza): A healthcare professional may prescribe baloxavir marboxil (Xofluza) to treat or prevent the flu. It is an oral antiviral medication approved for treating acute uncomplicated flu in people who have been symptomatic for less than 48 hours and those at high risk of developing flu-related complications. It may help prevent symptoms if you have been exposed to the virus but do not currently feel unwell. You should not take this medication if you are pregnant, breastfeeding, have a progressive health condition like multiple sclerosis (MS), or are immunocompromised (have a weakened immune system).

A doctor or another healthcare professional may prescribe these alternatives depending on several factors, such as your age, the severity of symptoms, and the specific flu type. Consider speaking with them to determine the most appropriate treatment option.

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How to get Tamiflu

Tamiflu is a prescription medication, meaning you can only get it through a doctor or another prescribing healthcare professional.

Healthcare professionals typically prescribe Tamiflu to people who have tested positive for the flu virus and have symptoms. Sometimes they may also use Tamiflu as postexposure prophylaxis (to prevent the virus). 

To get Tamiflu, scheduling an appointment with a doctor or another healthcare professional is required. During the appointment, they will assess your symptoms, medical history, and other relevant factors to determine if Tamiflu is appropriate for your needs.

Summary

Tamiflu usually starts working within 48 hours of noticing symptoms. It works by inhibiting the growth and spread of the flu virus in your body, helping to alleviate symptoms and shorten the duration of the illness.

A healthcare professional may recommend Tamiflu if you have been diagnosed with the flu and started experiencing symptoms in the last 48 hours, especially if you are at a higher risk of complications. 

Although healthcare professionals often prescribe Tamiflu, there are alternatives available. To get Tamiflu, you need a prescription from a doctor or another prescribing healthcare professional who will assess your condition and provide appropriate treatment.

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