Zoloft is a brand-name medication of sertraline. It is an antidepressant that helps treat several conditions like major depression and panic attacks.
Zoloft is a selective serotonin reuptake inhibitor (SSRI), which helps to improve your overall mood by increasing serotonin levels in the brain. Serotonin is a neurotransmitter that sends electrical impulses in the brain from one neuron to the next.
You may not feel a difference right away, but you will notice changes in the coming weeks and months as your body adjusts to the medication.
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How quickly does Zoloft start to work?

When beginning a new antidepressant, it may take some time for it to take effect. It’s important to know that this can vary for each individual.
It may take up to 2 weeks before you notice an improvement in your symptoms. However, it can also take between 4 and 6 weeks to feel the full effects of the medication.
If you have been taking Zoloft for longer than 6 weeks and have not noticed an improvement in your symptoms, consider speaking with a healthcare professional. They can increase your dosage or suggest a new antidepressant that may be more suitable for your needs.
What conditions can Zoloft help with?
While Zoloft (sertraline) is commonly used to treat depression, it can also help treat the following conditions:
- general anxiety disorder
- panic disorder
- eating disorders
- post-traumatic stress disorder
- certain sexual dysfunction conditions
What are the side effects of Zoloft?
Zoloft is generally very well-tolerated, but it can lead to several side effects when you begin the medication. This is because your body needs some time to adjust to the drug.
Common side effects that may occur when beginning Zoloft include:
Consider speaking with a doctor if you experience any of these side effects. They can help work out whether your dosage needs lowering or a different medication may be more suitable.
In some instances, Zoloft can cause adverse side effects, such as seizures. If you experience a seizure, it is important to seek medical support immediately.