Lexapro may offer symptom relief within 2 weeks of consistent use, but individual response times vary. For moderate to severe symptoms of depression or anxiety, Lexapro may take over 6 weeks to work.
Medically reviewed by Alexandra Perez, PharmD, MBA, BCGP
Lexapro is an antidepressant medication approved by the Food and Drug Administration (FDA) for depression and generalized anxiety disorder (GAD). You can also find it under the generic name escitalopram.
Lexapro belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs), which block the reabsorption of serotonin in your brain, helping to regulate mood.
Your healthcare professional may also prescribe Lexapro off-label. This means using the medication for purposes other than the ones the FDA approved it for, such as social anxiety and post-traumatic stress disorder (PTSD).
Lexapro and escitalopram are available in tablet and liquid form for oral administration.
Need a refill for escitalopram oxalate (Lexapro)? You may be able to get an online prescription through Optum Perks in as little as 15 minutes with no video or appointment needed. Learn more here.
100% online care
Treatment plans in 15 minutes or less for 40+ conditions.
Lexapro does not have an immediate effect. The medication typically takes 1–2 weeks of consistent use to reach its full therapeutic effect.
However, the exact time frame for achieving symptom relief may vary depending on various factors. These include symptom severity, individual tolerance to the medication, complementary treatment approaches, and the condition being treated.
For the treatment of depression, Lexapro may take 6–8 weeks to work for symptoms like low motivation or sad mood. In the case of anxiety disorders, Lexapro may also take a few weeks to reduce symptoms effectively.
This doesn’t mean you won’t experience improvement as you start taking Lexapro. You may start noticing a gradual change within the first 2 weeks. You may need to wait longer to experience the full effects of the medication.
If you feel Lexapro isn’t working for you, consult your prescribing professional before discontinuing the medication.
How many hours does Lexapro’s effect last?
Lexapro’s immediate effects may last for around 24 hours. However, because the medication is often taken once daily, usually in the morning or evening, the effects are cumulative and can’t be calculated on a daily basis. Long-term use of Lexapro translates into an increased effect on your mood until brain chemicals are balanced.
Dosages and frequency may vary depending on the severity of your condition, your response to the medication, and any potential side effects.
Only a healthcare professional may tailor your treatment.
Lexapro and escitalopram have a half-life of approximately 27–33 hours. “Half-life” refers to the time it takes for a medication in your blood to reduce by half. In other words, it describes how long it takes for the drug to leave your body naturally.
How do you know Lexapro is working?
Doctors assess the effectiveness of Lexapro by monitoring a person’s symptoms over time rather than after a single use. After several weeks of consistent use, you may notice:
Improved mood: Lexapro helps regulate mood by balancing serotonin levels in the brain. As treatment progresses, you may notice changes in mood and increased motivation.
Enhanced daily functioning: As Lexapro starts to take effect, you may find it easier to engage in daily activities, enjoy social interaction, and pursue hobbies or interests.
Decreased anxiety or worry: Lexapro significantly reduces the frequency or intensity of anxiety symptoms, such as racing thoughts, restlessness, or physical sensations like heart palpitations and muscular tension.
Everybody is different, though. The effects of Lexapro on you may vary slightly from its effects on other people. In general, with time, you’ll know Lexapro is working if you find a degree of relief from some or all of your symptoms.
If you need help covering the cost of depression and anxiety medications, the free Optum Perks Discount Card could help you save up to 80% on prescription drugs. Follow the links on drug names for savings on that medication, or search for a specific drug here.
Free prescription coupons
Seriously … free. Explore prices that beat the competition 70% of the time.
SNRIs may be an alternative if you experience side effects with SSRIs or have specific symptoms that may benefit from serotonin and norepinephrine modulation.
Benzodiazepines
Benzodiazepines enhance the effects of a neurotransmitter called gamma-aminobutyric acid (GABA), which can help alleviate anxiety symptoms. However, they are generally prescribed for short-term use due to the potential for dependence and severe side effects.
The effectiveness of Lexapro varies from person to person. While some people may experience relief from depression and anxiety symptoms within 2 weeks, others may require more time.
It’s essential to remain patient and consistent with your medication and remember to regularly communicate with a doctor to track progress and make necessary adjustments.
Article resources
Blumenthal JA, et al. (2021). Effect of exercise, escitalopram, or placebo on anxiety in patients with coronary heart disease: The understanding the benefits of exercise and escitalopram in anxious patients with coronary heart disease (UNWIND) randomized clinical trial. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2783295