Key takeaways
- Cefdinir is a broad-spectrum antibiotic that doctors may prescribe as a second-line treatment for uncomplicated urinary tract infections (UTIs). Research suggests a dosage of 300 mg twice per day for 5 to 7 days is effective.
- Cefdinir works by weakening bacterial cell walls, making it easier for your immune system to clear the infection. It’s highly effective against common UTI-causing bacteria such as E. coli, Klebsiella, and Proteus, though some strains may resist it.
- Mild side effects of cefdinir can include diarrhea, nausea, and headache, while serious side effects may include severe skin reactions or anaphylaxis. Cefdinir can also interact with antacids, probenecid, and birth control medications.
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Overview
Urinary tract infections (UTIs) are common and uncomfortable conditions that can affect anyone. A doctor may prescribe antibiotics such as cefdinir to treat these infections and ease symptoms.
Cefdinir was available under the brand name Omnicef. However, the manufacturer of Omnicef discontinued the drug, and cefdinir is now only available as a generic drug.
How does cefdinir work for treating UTIs?

Cefdinir belongs to the drug class called cephalosporin antibiotics. It is a third-generation cephalosporin and a broad-spectrum antibiotic. This means it can treat many disease-causing bacteria, such as those that result in:
- bronchitis
- pneumonia
- skin infections
- sinus infections
- tonsil infections
- ear infections
- throat infections
Doctors may also prescribe cefdinir to treat uncomplicated UTIs. It’s not the first medication that doctors will try, but it is used as a second-line treatment.
Cefdinir works by killing bacteria or preventing their growth. Once you take cefdinir, the medication enters your bloodstream and reaches the infection site. It then weakens the bacteria’s cell walls, making it easier for your immune system to clear the infection.
What dosage of cefdinir should I take for a UTI?
Cefdinir comes in the following forms and strengths. Both forms are oral, which means you take them by mouth.
- Capsule: 300 milligrams (mg).
- Suspension (a type of liquid mixture): 125 mg/5 milliliters (mL) or 250 mg/5 mL
The dose and length of treatment for UTIs depend on the severity of the infection, your age, overall health, and how often you experience UTI infections.
Research suggests a cefdinir dosage of 300 mg twice per day for 5 to 7 days is effective for treating UTIs. However, be sure to follow the dosage instructions your doctor prescribes.
You must complete the entire course of antibiotics even if you start feeling better before treatment has ended. This helps to ensure the infection clears.
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Get free cardHow effective is cefdinir?
Doctors usually prescribe cefdinir as a second-line treatment. Doctors will suggest a second-line treatment after the initial treatment has failed, stopped working, or has side effects that you cannot tolerate.
A 2021 study investigated the effectiveness of cefdinir in treating children with UTIs. Researchers concluded that cefdinir was not only effective in treating this condition but also had a lower rate of treatment failure compared with other commonly used antibiotics.
It’s important to note that the effectiveness of cefdinir may vary depending on the specific cause of the UTI. For example, while cefdinir is highly effective against common UTI-causing bacteria such as E. coli, Klebsiella, and Proteus, other strains may resist cefdinir.
What are the potential side effects of cefdinir?
Like with all medications, cefdinir can result in both mild and severe side effects.
Mild side effects of cefdinir can include:
- diarrhea
- vomiting
- nausea
- abdominal pain
- headache
- vaginal itching
- fever
- unusual tiredness or weakness
Serious side effects of cefdinir can include:
- severe skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis
- Clostridioides difficile infection
- anaphylaxis, a serious allergic reaction
If you experience any severe side effects while taking cefdinir, you should seek medical support immediately.
Your doctor can tell you more about what side effects may occur while taking cefdinir.
What are the possible drug interactions of cefdinir?
Cefdinir can interact with certain drugs and lead to unpleasant side effects. To help avoid any potential drug interactions, consider speaking with a pharmacist or doctor about any prescription or over-the-counter medications you are taking before beginning cefdinir.
Cefdinir may interact with the following drugs:
- antacids, such as calcium carbonate (Rolaids)
- probenecid (Probalan), a gout medication
- vaccines, such as the cholera live vaccine
- birth control such as drospirenone/ethinyl-estradiol (Yaz)
Summary
Cefdinir is an effective broad-spectrum antibiotic available as an oral capsule or oral suspension that doctors may prescribe to treat uncomplicated UTIs.
Cefdinir works by weakening bacteria’s cell walls, making it easier for your immune system to clear the infection.
As with all medications, cefdinir may cause various side effects and can interact with other medications. Always speak with a doctor or pharmacist before taking cefdinir to avoid any unpleasant side effects and potential drug interactions.
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