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Medically Approved

Does doxycycline make you tired?

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Why do I feel tired?How long will I feel tired?Should I rest more?Summary
Medically reviewed by Alexandra Perez, PharmD, MBA, BCGP
Written by Rashida Ruwa, RN
Updated on

Key Takeaways

  • Tiredness isn’t usually a side effect of doxycycline, but other side effects such as stomach problems and headaches may cause you to feel tired.
  • Fatigue experienced with doxycycline can vary based on factors such as your dosage, metabolism, overall health, and the length of your treatment. Side effects typically lessen within a few weeks as your body adjusts to the drug.
  • While there’s no scientific evidence suggesting the need to rest more while taking doxycycline, getting additional rest allows your body to focus on healing from the bacterial infection being treated.

Overview

Doxycycline is an antibiotic that’s commonly prescribed to treat various bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted diseases.

Doxycycline is available in both generic and brand-name forms, such as Vibramycin. While this medication effectively treats infections, some people report feeling unusually tired during treatment. However, tiredness isn’t one of doxycycline’s most commonly reported side effects.

Read on to learn how doxycycline can cause fatigue in some people and what to expect during treatment.

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Why do I feel tired when I take doxycycline?

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While fatigue isn’t a common side effect of doxycycline, some people may experience unusual tiredness when taking the medication.

It’s not fully clear why doxycycline can make you feel tired, but like many medications, it can alter typical body functions.

Doxycycline may affect your body’s energy production, and use more energy to process the medication or manage the infection. This could lead to a feeling of tiredness.

Other doxycycline side effects may also indirectly contribute to feeling fatigued. The most common side effects of doxycycline include:

  • Stomach problems: Nausea, vomiting, and diarrhea can lead to dehydration and a loss of nutrients, both of which can make you feel more tired.
  • Sun sensitivity: Increased sensitivity to sunlight can make outdoor activities uncomfortable. This could lead to reduced time spent outside and, as a result, a decrease in energy levels.
  • Headaches and dizziness: These can drain energy, making it hard to focus or stay active, which may lead to fatigue and an overall sense of tiredness.

Less commonly, doxycycline can cause severe allergic reactions like Stevens-Johnson syndrome, which can lead to general malaise before the more severe symptoms like skin rash and blisters appear.

How long will I feel tired?

The duration of fatigue after taking doxycycline can vary depending on several factors, such as:

  • your metabolism
  • your overall health
  • the dosage of doxycycline that you take
  • the length of treatment

Fatigue is not a typical side effect of doxycycline, but side effects can vary from person to person. Generally, as your body adjusts to the medication, side effects like fatigue should start to go away within a few weeks.

However, each person’s experience may differ. Other possible side effects that may indirectly contribute to tiredness include:

  • nausea
  • vomiting
  • diarrhea
  • upset stomach

These stomach problems can lead to dehydration or lack of certain nutrients, which can make you feel unusually tired.

In most cases, doxycycline side effects are mild and should go away after stopping doxycycline. However, if you’re recovering from a severe or ongoing infection, the recovery process may cause you to feel tired, rather than the medication itself. 

If you continue to feel tired a few days after stopping doxycycline, it’s best to talk with your doctor. They can help you rule out other causes.

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Should I rest more while taking doxycycline?

Currently, there’s no scientific evidence suggesting that you need to rest more while taking doxycycline. However, it’s always best to follow your doctor’s advice regarding activity levels while on medication. 

Antibiotics like doxycycline are prescribed to treat bacterial infections, which can lower your energy levels as you recover. Getting more rest allows your body to focus on healing. 

To manage fatigue and support recovery, consider the following tips:

  • Stay hydrated: If you experience diarrhea or other stomach or digestive problems, drinking plenty of water helps prevent dehydration, a common cause of fatigue. 
  • Eat balanced meals: Focus on nutrient-dense foods like fruits, vegetables, lean proteins, and whole grains to maintain your energy levels.
  • Take short naps: Short naps can help restore energy without disrupting nighttime sleep. Aim for 20 to 30 minute naps to avoid feeling groggy.

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Summary

Feeling tired isn’t a common side effect of doxycycline. But, doxycycline may cause fatigue due to other side effects like nausea, diarrhea, or headaches. 

Most doxycycline side effects are mild and usually go away after stopping the medication. Resting, staying hydrated, and eating a balanced diet can help ease these symptoms as your body recovers from both the infection and the treatment.

If your fatigue worsens, doesn’t go away, or interferes with daily activities after stopping doxycycline, talk with your doctor.

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