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Medically Approved

Cholestyramine oral suspension dosage: A detailed guide

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Doctors prescribe cholestyramine oral suspension for high cholesterol and itching related to partial bile duct obstruction. You take it by mouth twice per day.
Medically reviewed by Elizabeth Scheffel, PharmD
Updated on

This article describes cholestyramine oral suspension’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for cholestyramine. If you want to know more about cholestyramine oral suspension, see this overview article. It covers details about the drug’s uses, side effects, and more.

Cholestyramine oral suspension is a generic version of the brand-name drugs Questran and Prevalite. Cholestyramine only comes in a powder for oral suspension, either as single-dose packets (sachets) or in a container with a measuring scoop.

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Form and strengths of cholestyramine

Cholestyramine oral suspension comes as follows:

  • Form: powder that’s mixed with liquid, which you’ll take by swallowing
  • Strength: 4 grams (g) per dose

Dosage of cholestyramine

This article describes the recommended dosages for cholestyramine oral suspension. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of cholestyramine oral suspension without your doctor’s recommendation.

Usual recommended dosages of cholestyramine in adults

Usually, doctors start by prescribing a low dosage of cholestyramine oral suspension. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of cholestyramine oral suspension that gives the desired outcome.

Dosage for high cholesterol and other conditions, as well as itching related to partial bile duct blockage

  • Starting dosage: 1 pouch or spoonful once or twice per day
  • Maintenance dosage: 1 to 2 pouches or spoonfuls twice per day
  • Maximum dosage: 6 pouches or spoonfuls in 24 hours

Cholestyramine powder should not be taken dry. Always mix the powder with water or some other liquid before swallowing.

Dosages of cholestyramine in children

The dosage of cholestyramine in children up to age 17 years is based on weight in kilograms (kg). For reference, 1 kg is about 2.2 pounds.

Usually, children will take 240 milligrams per kg of body weight per day. This is divided into two or three doses. Most children won’t need more than 8 g per day.

Dosage adjustments for cholestyramine

Your doctor will prescribe a dosage of cholestyramine oral suspension based on several factors. These include:

  • the specific condition being treated and how severe it is
  • your age
  • other medications you are taking
  • other health conditions you may have

Missed dose of cholestyramine

Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of cholestyramine oral suspension. They may advise you to take the missed dose. Or they may advise you to skip it and take your next dose as scheduled.

For tips on how to plan your doses of cholestyramine oral suspension and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about cholestyramine oral suspension and its dosage.

Are there any foods to avoid when taking cholestyramine?

Cholestyramine oral suspension should be taken at mealtime.

While there are no specific foods to avoid when taking cholestyramine, this drug can prevent your body from absorbing fat. This includes vitamins that dissolve in fat, such as vitamins A, D, E, and K. If you take cholestyramine long term, you may need to take supplements for these vitamins to prevent deficiencies.

Speak with your doctor if you have questions about how cholestyramine interacts with food.

Can cholestyramine be used for diarrhea?

Possibly. But cholestyramine oral suspension is not approved to treat diarrhea. In some cases, doctors may prescribe cholestyramine off-label for certain types of diarrhea. With off-label use, doctors prescribe a drug for a purpose other than what it’s approved for.

The most common type of diarrhea that cholestyramine is used for is bile-acid diarrhea. This is when there is too much bile acid in your colon, which can lead to diarrhea.

Cholestyramine is not used for diarrhea that’s caused by a virus, bacteria, or other type of infection. It should not be used without a prescription from your doctor.

Speak with your doctor or pharmacist to learn more about the medications that may work best for your diarrhea.

Is cholestyramine taken long term?

Cholestyramine oral suspension may be prescribed for short- or long-term treatment depending on why you’re taking it.

If you’re taking this drug for high cholesterol, doctors typically prescribe cholestyramine as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

If you are taking it for itching related to partial bile duct blockage, doctors typically prescribe cholestyramine as a short-term treatment.

If you have questions about how long you should take cholestyramine oral suspension, talk with your doctor.

How cholestyramine is taken

You’ll swallow cholestyramine oral suspension twice per day.

Cholestyramine oral suspension is a powder that needs to be mixed with liquid that you swallow. The powder comes in either single-dose packets or sachets or in a container with a measuring scoop. It’s important that you do not take the powder on its own without mixing it in a liquid.

To take this medication, you’ll mix the powder with at least 2 to 6 ounces of water or some other liquid before swallowing it. Avoid mixing the powder with carbonated water or beverages.

Your doctor may advise that you take this medication around the same time each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

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Overdose of cholestyramine

It’s important that you do not take more cholestyramine oral suspension than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of cholestyramine overdose

An overdose can lead to an obstruction in your intestines. Symptoms of an overdose can include:

  • severe stomach pain or cramping
  • nausea or vomiting
  • constipation
  • inability to pass gas
  • feelings of fullness

What to do if you take too much cholestyramine

If you think you’ve taken too much cholestyramine, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for cholestyramine oral suspension. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of cholestyramine oral suspension without your doctor’s recommendation. You should take cholestyramine oral suspension exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • What should I do if I miss a dose of cholestyramine oral suspension?
  • If the starting dosage doesn’t help me, how long will it take to increase my dosage?
  • How long will I need to take cholestyramine oral suspension?

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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