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Medically Approved

Non-NSAID pain relief: 4 alternatives to NSAIDs

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AcetaminophenCapsaicin topical creamsArnica topical creamsMenthol topical pain reliefWhich treatment is right for me?Seeking helpSummary
Several alternative options are available to nonsteroidal anti-inflammatory drugs (NSAIDs), which can be just as effective in soothing pain. Read on to learn more.
Medically reviewed by Philip Ngo, PharmD
Written by D. M. Pollock
Updated on

Not everyone can take NSAIDs, as they can interact with certain health conditions and lead to complications or side effects. For example, if you have kidney disease or liver disease, you will have a higher chance of side effects from NSAIDs. It is also possible to be allergic to several NSAIDs.

If this is the case, you may wish to understand the other options available for managing short-term pain, such as headaches. If you need long-term pain management, it is important you seek advice from a doctor.

While there are other medications available to help relieve pain, there are also natural substances that can soothe pain while also relieving inflammation.

Read on to learn more about these alternatives and understand their benefits and risks.

Acetaminophen

Female putting topical cream on her elbow as an alternative to taking NSAIDs
Carol Yepes/Getty Images

Acetaminophen, the generic version of Tylenol, is a non-opioid pain-relieving medication that can help manage fever symptoms. It is available in several forms, such as oral tablets, liquid solutions, or capsules. Acetaminophen is one of the most commonly used over-the-counter (OTC) pain relievers that can help with mild to severe pain.

Taking acetaminophen instead of an NSAID can help reduce any risks you may have of heart problems. However, as it contains no anti-inflammatory properties, it can’t help reduce swelling, unlike common NSAIDs such as ibuprofen (Advil).

It is also important you stick within the safe dosage limits, as taking too much acetaminophen can cause a buildup of toxins in your liver. Try to stick below 3,000 mg a day whenever possible.

If you need help covering the cost of medications, the free Optum Perks Discount Card could help you save up to 80% on prescription drugs. Follow the links on drug names for savings on that medication, or search for a specific drug here.

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Capsaicin topical creams

Capsaicin is a natural substance present in chili peppers, which gives it a spicy taste. It is a topical cream that can help reduce pain in specific areas, such as muscular pain. It works by stimulating your pain receptors and reducing your pain sensitivity.

Many people find it useful for managing arthritis pain.

Fortunately, there are very few safety concerns over using capsaicin creams. However, it is common to experience temporary burning or redness wherever you apply the cream. This is why keeping capsaicin creams away from your eyes, nose, mouth, and any broken skin is important.

Capsaicin topical creams are available OTC and through a prescription.

Arnica topical creams

Arnica is a plant that belongs to the same family as marigolds and daisies. It has been used for centuries in traditional medicine for pain relief and inflammation management.

While research is mixed, many studies prove the positive effects of arnica for reducing pain, particularly in people with arthritis.

Other types of pain that can respond well to creams containing arnica extracts include:

  • low back pain
  • post-operative pain
  • other muscular pains, such as tendinitis

It’s important to know that arnica products do not have standardized dosing across products, so different manufacturers will have varying concentrations.

If you use arnica creams for a long time, you may be at risk of causing skin irritation and peeling. It is important to monitor the condition of your skin when you apply the cream.

Most natural arnica creams are very low in dosage, so typically safe for use. However, it is important to avoid using higher strength treatments like oral tablets or oil unless you are under the supervision of a doctor.

It’s also important to remember that arnica products are homeopathic products, and there is limited evidence to support them as an effective treatment option.

The Food and Drug Administration (FDA) has not reviewed arnica products for safety and effectiveness. These products are usually recommended based on people’s personal experiences with the products rather than the quality of the research behind the products.

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Menthol topical pain relief

Topical menthol treatments (like Biofreeze) are effective OTC creams and can treat painful conditions like migraine and musculoskeletal pain. They work by creating a cooling sensation on the skin to distract you from the pain beneath.

These are typically only suitable for short-term relief, as the pain will reappear after the menthol wears off.

Menthol topical creams are typically very safe. However, in some rare cases, skin burns can occur from the use of these OTC creams. If you experience any sign of skin injury or blistering after applying a cream, seek medical help immediately.

How to know which one is right for you

When deciding which treatment is best suited to your needs, it’s important to consider the type of pain you are trying to manage.

For example, none of the above treatments will be suitable for long-term and consistent pain. However, if the pain is mild or temporary, such as a headache or muscular injury, they may be able to help relieve symptoms.

Often, trial and error is the best way to find the most effective alternative pain relief for you. However, if you are trying to manage long-term or chronic pain, speak with a doctor about creating a treatment plan that works for you.

When to speak with a doctor

If you have previously been managing pain with at-home treatments, but you notice a change, such as increasing pain intensity, or that the treatment is no longer as effective, this may be a sign that you need to speak with a doctor.

For example, if your headaches become more frequent and intense, you may be experiencing migraine. Migraine has its own non-NSAID treatments that will manage your symptoms more effectively than the above treatments.

Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) can be effective pain-relieving medications. However, they are not the only option for managing short-term pain.

Several other options can help relieve symptoms, including:

  • capsaicin topical creams
  • acetaminophen
  • arnica topical creams
  • menthol topical pain relief

However, if you experience chronic or severe pain, it is important to speak with a doctor. Together, you can create an effective treatment plan to manage your pain without NSAIDs.

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