What is TrumpRx?

Key takeaways

• TrumpRx is a government portal that offers deep discounts on 54 specific, high cost branded medications like GLP-1s and fertility drugs.
• To use TrumpRx, you must pay out-of-pocket and bypass your insurance. While this can save you hundreds upfront, these payments typically do not count toward your annual insurance deductible or out-of-pocket maximum.
• While Optum Perks is available in all 50 states, TrumpRx coupons are currently not accepted in California or Massachusetts due to state laws.

Overview

Launched in February 2026, TrumpRx.gov is a website run by the federal government designed to lower the cost of certain brand-name medications. TrumpRx is a price-comparison portal, not a pharmacy. Instead of providing medications directly, it links to manufacturer deals or provides coupons you can then take to your local pharmacy.

The program is built on “Most-Favored-Nation” (MFN) pricing, meaning the administration negotiated with drugmakers to offer prices to Americans that are closer to the lower rates paid in other countries like the United Kingdom or Canada.

Need a diagnosis or prescription quickly? Optum Perks offers personalized on-demand care in as little as 15 minutes. For $29, answer a few questions online and receive a diagnosis and treatment plan from a US-licensed healthcare professional. Get started here.

How does TrumpRx work?

People in the United States currently pay some of the highest prices in the world for prescription medications, and according to a 2025 poll, more than 1 in 4 adults under age 65 report difficulty affording their medication.

The aim of TrumpRx is to introduce “Most Favored Nation” (MFN) pricing, which involves capping U.S. prescription drug prices at the lowest prices paid in other developed nations, like the UK or Canada. It includes discounts on several drugs from 16 manufacturers, including AstraZeneca, Eli Lilly, GSK, Novo Nordisk, and Pfizer.

The platform works like a search engine for discounts on high cost, brand-name medications, where you search for your medication on the website. The site will then show you either a digital coupon you can download to present at a pharmacy to access the discount or send you to the manufacturer’s website to receive a discount directly.

It’s important to note that TrumpRx discounts cannot be used alongside insurance. The discounts are only available to people who are paying for the medication out of pocket.

MORE: Learn about the medications getting more affordable in 2026.

What pharmacies accept TrumpRx?

TrumpRx coupons should be accepted at most major U.S. pharmacies, including large chains like Walgreens and CVS. However, due to specific state laws regarding manufacturer-sponsored discounts, TrumpRx coupons currently cannot be used at pharmacies in California or Massachusetts.

It’s important to note that TrumpRx is not an online pharmacy itself — it doesn’t provide the medications to you. Instead, it provides coupons that you can take to an in-person pharmacy to receive a discount.

Which medications are included in the program?

TrumpRx currently includes 54 medications, mostly costly branded drugs used to treat conditions like asthma, infertility, diabetes, and arthritis. Here are examples of some of the medication savings offered through TrumpRx.

GLP-1s

GLP-1 medications are used to manage type 2 diabetes, and they’re also increasingly being used as weight loss drugs. Prices for these medications can be very high, and they often are not covered by insurance. TrumpRx offers savings on Ozempic, Wegovy (both the injectable and oral forms), and Zepbound.

Here are the savings you can expect:

• The monthly prices of Ozempic and injectable Wegovy reduce from $1,028 and $1,349, respectively, to an average of $350 and as low as $199, depending on the dosage.
• The monthly price of oral Wegovy falls from $1,349 to a minimum price of $149, depending on the dosage.
• The monthly price of Zepbound will go from $1,088 to an average of $346 and as low as $299, depending on the dosage.

Fertility medications

Fertility treatments are also very costly, and in many cases, these are not covered by insurance plans. According to the U.S. government, people accessing fertility treatments may save an average of $2000 or more per cycle on common fertility medications.

Some of these medications include:

• Gonal-F
• Cetrotide
• Ovidrel

Other medications

There are many other medications included under TrumpRx, including:

• diabetes medications like Januvia
• blood thinners like Plavix
• cholesterol drugs like Repatha
• migraine medications like Aimovig
• asthma medications like the Advair Diskus inhaler

You can search for your medication on the TrumpRx website to see if it’s included.

Who benefits the most from TrumpRx?

Because TrumpRx discounts can’t be used alongside insurance, this program is aimed at different types of patients:

• People without insurance: If you don’t have health insurance, TrumpRx discounts can be a good option for you, as you will be paying out of pocket for all of your medications.
• People with high deductibles: If you have a very high deductible and only take one or two medications, you might spend the entire year paying full price without ever reaching the point where your insurance kicks in. While using TrumpRx for medications won’t count towards your deductible, it can still be a good option to save overall for people who don’t expect to hit their deductible in a plan year.
• People with limited coverage: Many health plans don’t cover every medication you may be prescribed, especially weight loss or fertility medications. Using TrumpRx can mean you don’t need to pay full price for these drugs.

If you’re trying to decide whether to use TrumpRx, it’s important to get to know your insurance plan (if you have one). You can research what your deductible is and what medications are covered under your plan’s formulary. This can help you compare prices between your insurance and TrumpRx discounts.

Pro tip: Before you head to the pharmacy, you can ask your doctor for the cash price and the insurance price of your prescription. If the TrumpRx price is lower than your insurance copay, just tell your pharmacist you don’t want to use insurance.

TrumpRx vs. Optum Perks

While TrumpRx and Optum Perks both provide discounts on prescription medications, they both have different benefits and strengths:

• Variety of drugs: TrumpRx currently offers discounts on 54 medications, whereas Optum Perks has coupons for thousands of drugs approved by the Food and Drug Administration (FDA).
• Types of medications: TrumpRx focuses on discounts for costly brand-name medications, whereas Optum Perks offers discounts on a wide variety of generic medications, which tend to be significantly cheaper than brand-name counterparts.
• Accessibility: Currently, residents of California and Massachussets cannot access TrumpRx due to local laws. However, Optum Perks is a traditional pharmacy discount program that is available to residents in all 50 states and is accepted at thousands of pharmacies nationwide, including independent local drugstores that may not be set up to process TrumpRx deals.

If you’re looking to save on medication costs, it’s important to compare prices across different programs, including insurance, TrumpRx, and Optum Perks. You can also speak with a doctor or pharmacist for advice.

Optum Perks now also offers reduced pricing on over 60 branded medications, and consumers can now save an average of 22.5%, or $91, per prescription. The final price of your medications may be discounted at the pharmacy even further than the offers listed on our site.

To see your final cost, simply present your Optum Perks card to the pharmacist — your savings will be applied in real time based on our most current discounts.

If you need help covering the cost of medications, the free Optum Perks Discount Card could help you save up to 80% on prescription drugs. Plus, you can now get them delivered to your home in as little as 3 days. Search for your medication here.

Summary

TrumpRx is a new program implemented by the U.S. government aiming to reduce medication costs for Americans. It currently includes 54 high cost, brand-name medications from various manufacturers, including GLP-1 drugs and fertility treatments.

TrumpRx can’t be used alongside insurance, so it’s important to compare the TrumpRx price with your insurance deductible to figure out which option will be cheaper. You can also compare prices with the Optum Perks coupons, too.

Download the free Optum Perks Discount Card to save up to 80% on many prescription medications. Plus, you can now get them delivered to your home in as little as 3 days. Search for your medication here.