Tadalafil oral tablet interactions: A detailed guide
This article describes possible interactions with tadalafil oral tablet. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.
Other drugs and tadalafil
The drugs in the list below may interact with tadalafil oral tablet. This article doesn’t include all drugs that may interact with tadalafil.
Drug classes that may interact with tadalafil oral tablet include:
- high blood pressure drugs:
- certain antibiotics:
- certain antifungals:
- certain drugs used to treat HIV:
- certain antiepileptic drugs:
- other PDE5 inhibitors:
- guanylate cyclase stimulators:*
* To learn more about this interaction, see the “When to avoid tadalafil” section below.
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When to avoid tadalafil
Certain health conditions or other factors could increase some risks with tadalafil oral tablet. Because of this, doctors may not prescribe tadalafil in these cases. These health conditions or other factors are called contraindications.
Here’s a list of contraindications for tadalafil oral tablet:
- Taking a guanylate cyclase (GC) stimulator medication. If you take a GC stimulator drug, taking tadalafil oral tablet may cause severe low blood pressure. For examples of GC stimulator medications, see the “Other drugs and tadalafil” section above.
- Taking a nitrate medication. If you take a nitrate medication, taking tadalafil oral tablet may cause serious side effects. In rare cases, these side effects can be life threatening or even fatal. For examples of nitrate drugs, see the “Other drugs and tadalafil” section above.
- Past allergic reaction to tadalafil. If you’ve ever had an allergic reaction to tadalafil oral tablet, taking it again may cause another allergic reaction.
Before you start taking tadalafil, tell your doctor if any of the tadalafil warnings listed above relate to you. They can recommend whether you should take tadalafil.
Alcohol and tadalafil
Tadalafil oral tablet is known to have interactions with alcohol.
Taking tadalafil oral tablet and drinking alcohol may cause:
- low blood pressure, including a sudden drop when you stand or sit up
- increased heart rate
If you drink alcohol and have concerns about avoiding it while taking tadalafil oral tablet, talk with your doctor.
Other interactions and tadalafil
Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether tadalafil oral tablet has these interactions.
The information below doesn’t include all other possible interactions with tadalafil.
Tadalafil and food
Tadalafil has interactions with food. It may interact with grapefruit or grapefruit juice. Consuming grapefruit or grapefruit juice and taking tadalafil can increase the level of tadalafil in your body. This may raise your risk of side effects from the drug.
Because of this, talk with your doctor or pharmacist about what foods you should avoid while taking tadalafil oral tablet.
Tadalafil and supplements
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Tadalafil interactions with herbs
Taking tadalafil and St. John’s wort can make tadalafil less effective. It may no longer work to treat your condition.
Because of this, ask your doctor or pharmacist before using any herbs while taking tadalafil oral tablet.
Tadalafil interactions with vitamins
Tadalafil oral tablet isn’t known to interact with any vitamins. But this doesn’t mean interactions with vitamins can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before using any of these products while taking tadalafil oral tablet.
Tadalafil and vaccines
Tadalafil oral tablet isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before receiving any vaccines while taking tadalafil oral tablet.
Tadalafil and lab tests
Tadalafil oral tablet isn’t known to interact with lab tests. But this doesn’t mean interactions with lab tests can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before having any tests while taking tadalafil oral tablet.
Tadalafil and cannabis or CBD
Taking tadalafil and cannabis can increase the risk of side effects of tadalafil.
Before you take tadalafil, tell your doctor and pharmacist if you use cannabis. Doing so may help prevent possible interactions.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Health factors and tadalafil
Certain medical conditions or other health factors may increase the risk of interactions with tadalafil oral tablet. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking tadalafil, tell your doctor about your health history. They’ll determine whether tadalafil is right for you.
These health conditions or other factors might interact with tadalafil oral tablet:
- bleeding conditions, such as hemophilia
- blood cell conditions, such as sickle cell anemia
- heart conditions, such as heart failure
- kidney conditions, such as chronic kidney disease
- liver conditions, such as alcohol-related liver disease
- low or high blood pressure
- past history of an eye condition called non-arteritic anterior ischemic optic neuropathy
- pulmonary hypertension
- an eye condition called retinitis pigmentosa
- past stroke
- stomach ulcer
- Peyronie’s disease
- past priapism
- past allergic reaction to tadalafil
Preventing tadalafil interactions
You may be able to help avoid certain interactions with tadalafil oral tablet. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.
Things to consider include:
- Whether you drink alcohol or use cannabis.
- Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
- What to do if you’re prescribed a new drug while taking tadalafil oral tablet.
Taking tadalafil exactly as prescribed can also help prevent interactions.
What to ask your doctor
If you have questions about tadalafil and possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Does my risk of interactions depend on whether I take tadalafil daily or only as needed?
- Does tadalafil have similar interactions as other PDE5 inhibitors, such as sildenafil?
- What should I do if I’m prescribed a new medication while taking tadalafil?
- Do I need to let you know if I make lifestyle changes, such as changes to my exercise routine or diet?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
- Cannabinoid (precipitant) medication affecting the metabolism of another (object) medication. (2020). https://sites.psu.edu/cannabinoid/files/2020/06/Cannabinoid-as-PRECIPITANT-Medication-Affecting-the-Metabolism-of-ANOTHER-OBJECT-Medication_04_25.pdf
- Food and Drug Administration. (2023). Orange Book: Approved drug products with therapeutic equivalence evaluations. https://www.accessdata.fda.gov/scripts/cder/ob/index.cfm
- Tadalafil- tadalafil tablet, film coated. (2023). https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/168a135b-1454-4def-9b03-c9a470bfcb5f/spl-doc