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Medically Approved

What is tacrolimus ointment prescribed for?

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EczemaDuration of treatmentSummary
Tacrolimus ointment is used to treat a type of eczema called atopic dermatitis. Doctors usually prescribe it to treat eczema that has not responded to other medications.
Medically reviewed by Jennie Olopaade, PharmD, RPH
Written by Lauren Lerner
Updated on

Tacrolimus ointment is used to treat moderate to severe eczema, also known as atopic dermatitis. Eczema is a condition that causes the skin to become itchy, inflamed, and dry.

Tacrolimus is usually prescribed to treat eczema that has not responded to other medications, such as topical steroids. It is a short-term medication that helps treat eczema flares. Tacrolimus helps reduce eczema symptoms by blocking a protein that activates immune cells. These immune cells cause symptoms like inflammation and itching. It is only available with a prescription from a doctor or healthcare professional.

Tacrolimus is especially useful for eczema that appears in sensitive areas like the face, where treatment with topical steroids may present a risk.

Tacrolimus ointment is a generic drug and also comes in a brand-name form called Protopic.

If you need a treatment plan or prescription for eczema, you can talk with your doctor. Or, you could use an online health service, like the one offered by Optum Perks.

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1975072776Iuliia Burmistrova/Getty Images

What is tacrolimus ointment used for?

Tacrolimus ointment is used to treat moderate to severe eczema. There are multiple types of eczema, but atopic dermatitis is the most common. In the United States, it affects more than 9.6 million children and about 16.5 million adults.

Eczema is a chronic (long-term) condition that can come and go, or even last throughout your life. It causes the skin to become itchy, inflamed, red or discolored, and dry. Although researchers don’t know exactly what causes eczema, they know that it’s linked to an overactive immune system, genes, and the environment.

Tacrolimus is a topical calcineurin inhibitor (TCI). Tacrolimus works to block calcineurin, a protein that works with the immune system to activate immune cells called T-cells. T-cells are linked to some of the inflammation and itching that go along with eczema. TCIs such as tacrolimus prevent the function of some T-cells, which weakens the immune response. This helps reduce inflammation and itching.

Tacrolimus is usually prescribed to treat eczema but has not responded to other medications, such as topical steroids. Healthcare professionals sometimes prescribe it to use along with topical steroids or as an alternative to topical steroids. They typically use it short term to treat eczema flares. But doctors may also prescribe it off-label for a longer period of time to help prevent eczema flares. Off-label use is when a healthcare professional prescribes a medication for a condition that the Food and Drug Administration (FDA) has not approved to treat.

Tacrolimus ointment is especially useful for eczema that appears in sensitive areas where treatment with topical steroids may not be suitable. This includes areas, such as:

  • face
  • neck
  • eyelids
  • outer genital skin

How long can you use tacrolimus ointment?

You can typically use tacrolimus ointment for 6 weeks at a time to see how your body responds to it. If it is effective at reducing your eczema symptoms, your doctor may ask you to continue using it as a maintenance treatment for 6 to 12 months.

Tacrolimus comes in two strengths: a 0.1% formulation and a 0.03% formulation. The 0.1% formulation is stronger and doctors usually prescribe it for adults.

You typically use tacrolimus ointment by applying a thin layer to the area of skin affected by eczema. You’ll apply the ointment twice daily. It is important to use the minimum amount of ointment you need and rub it in gently.

Once your symptoms clear up, your doctor will have you stop using tacrolimus ointment. Symptoms of atopic eczema often include:

  • itchiness
  • rash
  • redness or other color changes

If you don’t notice any relief from your symptoms after 6 weeks of using tacrolimus, tell your doctor. They may want to reexamine your skin or prescribe a different medication.

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How long does tacrolimus take to work?

After about 1 week of treatment with tacrolimus ointment, you may notice some relief in your eczema symptoms. The maximum level of improvement is usually seen after around three months of treatment with tacrolimus.

Summary

Tacrolimus ointment is used to treat a type of eczema called atopic dermatitis. It’s usually used on sensitive areas, like the face or eyelids, where treatment with other eczema medication is not suitable. Doctors may prescribe tacrolimus ointment when your eczema has not responded to other medications. They may also prescribe it alongside common eczema treatments like topical steroids or can use it as an alternative to topical steroids.

Healthcare professionals prescribe tacrolimus for 6 weeks at a time. It often takes about a week to start working. To learn more about tacrolimus ointment and its uses, talk with your doctor. If you need care as soon as possible, you can use an online health service.

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