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Ropinirole oral tablet interactions: A detailed guide

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Other drugsHealth factorsWhen to avoidAlcoholOther interactionsPreventionAsk your doctor
Ropinirole oral tablet is prescribed to treat symptoms of Parkinson’s disease and restless leg syndrome. This drug may interact with alcohol, tobacco, or cannabis products. It can also interact with other medications, such as antipsychotic drugs and birth control pills.
Medically reviewed by Bryson Russell, PharmD, MHSA, MSc
Updated on

This article describes possible interactions with ropinirole oral tablet. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.

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Other drugs and ropinirole

The drugs in the list below may interact with ropinirole oral tablet. This article doesn’t include all drugs that may interact with ropinirole.

Drug classes or drugs that may interact with ropinirole oral tablet include:

  • antipsychotic drugs:
  • birth control pills:
    • drug examples: ethinyl estradiol/desogestrel (Bekyree, others), ethinyl estradiol/drospirenone (Angeliq, others)
    • what might happen: can increase the risk of side effects of ropinirole
  • drugs containing estrogen:
    • drug examples: estradiol (Climara, others), conjugated estrogens (Premarin)
    • what might happen: can make ropinirole less effective
  • ciprofloxacin (Cipro):
    • can increase the risk of side effects of ropinirole
  • fluvoxamine (Luvox):
    • what might happen: can increase the risk of side effects of ropinirole
  • metoclopramide (Reglan, Gimoti):
    • what might happen: can make ropinirole less effective
  • promethazine:
    • what might happen: can make ropinirole less effective
  • rifampin (Rimactane):
    • what might happen: can make ropinirole less effective
  • zileuton (Zyflo):
    • what might happen: can increase the risk of side effects of ropinirole
  • phenytoin (Dilantin):
    • what might happen: can make ropinirole less effective

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Health factors and ropinirole

Certain medical conditions or other health factors may increase the risk of interactions with ropinirole oral tablet. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking ropinirole, tell your doctor about your health history. They’ll discuss any ropinirole warnings and determine whether the drug is right for you.

These health conditions or other factors might interact with ropinirole oral tablet:

When to avoid ropinirole

Certain health conditions or other factors could increase some risks with ropinirole oral tablet. Because of this, doctors may not prescribe ropinirole in these cases. These health conditions or other factors are called contraindications.

Here’s a contraindication for ropinirole oral tablet:

  • Past allergic reaction to ropinirole: If you’ve ever had an allergic reaction to ropinirole oral tablet, taking it again may cause another allergic reaction.

Before you start taking ropinirole, tell your doctor if the above relates to you. They can recommend whether you should use ropinirole.

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Alcohol and ropinirole

Ropinirole oral tablet is known to interact with alcohol.

Combining ropinirole and alcohol may increase the risk of drowsiness as a side effect. It could also increase the severity of certain side effects of ropinirole. These include problems thinking, coordination, and decision making.

If you drink alcohol, talk with your doctor about whether it’s safe to consume it while taking ropinirole oral tablet.

Other interactions and ropinirole

Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether ropinirole oral tablet has these interactions. 

The information below doesn’t include all other possible interactions with ropinirole.

Ropinirole and supplements

Before taking ropinirole oral tablet, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Ropinirole interactions with herbs

Ropinirole oral tablet isn’t known to interact with any herbs. But this doesn’t mean interactions with herbs can’t happen or won’t be identified later.

Because of this, ask your doctor or pharmacist before using any of these products while taking ropinirole oral tablet.

Ropinirole interactions with vitamins

Ropinirole oral tablet isn’t known to interact with any vitamins. But this doesn’t mean interactions with vitamins can’t happen or won’t be identified later.

Because of this, ask your doctor or pharmacist before using any of these products while taking ropinirole oral tablet.

Ropinirole and food

Ropinirole oral tablet isn’t known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist about what foods you should avoid while taking ropinirole oral tablet.

Ropinirole and vaccines

Ropinirole oral tablet isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist before receiving any vaccines while taking ropinirole oral tablet.

Ropinirole and lab tests

Ropinirole oral tablet isn’t known to interact with lab tests. But this doesn’t mean interactions with lab tests can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist before having any tests while taking ropinirole oral tablet.

Ropinirole and cannabis or CBD

Reports have shown cannabis (commonly called marijuana) and cannabis products may interact with ropinirole. Cannabidiol (CBD) is an example of a cannabis product.

Taking ropinirole and using cannabis products can increase the risk of certain side effects. These include drowsiness and problems with thinking, coordination, and decision making.

Before you take ropinirole, tell your doctor and pharmacist if you use cannabis. Doing so may help prevent possible interactions.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Preventing ropinirole interactions

You may be able to help avoid certain interactions with ropinirole oral tablet. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.

Things to consider include:

  • Whether you drink alcohol or use cannabis.
  • Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
  • What to do if you’re prescribed a new drug while taking ropinirole oral tablet.

Taking ropinirole exactly as prescribed can also help prevent interactions.

What to ask your doctor

If you have questions about ropinirole and possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

  • Do other drugs that could treat my condition have similar interactions?
  • Do I need to take my medications at different times throughout the day to avoid interactions?
  • Does my risk of interactions depend on my dosage of ropinirole?

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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