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Protonix dosage: A detailed guide

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Doctors prescribe Protonix for acid reflux and other conditions related to stomach acid. You take the oral forms by mouth once or twice per day. A healthcare professional gives the injection form.
Medically reviewed by Melissa Badowski, PharmD, MPH, FCCP
Updated on December 7, 2023

This article describes Protonix’s dosages, strengths, how to take it, and how it’s given. You’ll also find information on cost savings and coupon options for Protonix. If you want to know more about Protonix, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.

Protonix is a brand-name medication that comes as a tablet, granules for an oral suspension, and an injection*. It’s available in a generic version called pantoprazole. This article describes dosages of Protonix.

* The injection form is given by a healthcare professional by intravenous (IV) infusion, a type of injection that’s given into your vein over time.

Forms and strengths of Protonix

Protonix comes in these forms and strengths:

FormHow to take/receiveStrengths
oral tablettake by swallowing20 milligrams (mg)
40 mg
granules for oral suspension*take by swallowing40 mg
injectiongiven by a healthcare professional into a vein40 mg

* An oral suspension is a type of liquid mixture.

Dosage of Protonix

This article describes the recommended dosages for Protonix. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your Protonix dosage without your doctor’s recommendation.

Usual recommended dosages of Protonix in adults

Usually, doctors start by prescribing a standard dosage of Protonix. The dosages are in milligrams (mg).

PurposeRecommended doseFrequency
Treat erosive esophagitis related to gastroesophageal reflux disease (also called acid reflux or GERD)40 mg by mouth or injectiononce per day
Maintain healing of erosive esophagitis40 mgonce per day
Treat Zollinger-Ellison syndrome and other similar stomach acid conditions40 mg by mouth or
80 mg by injection
twice per day

Dosages of Protonix in children

The dosage of Protonix oral tablet and granules for oral suspension* for children ages 5 years and older is based on their weight in kilograms (kg†). Dosages are in milligrams (mg) per day. 

PurposeBody weight in kgRecommended dosage
treat erosive esophagitis related to GERD15 kg (or less) up to 40 kg20 mg once per day
treat erosive esophagitis related to GERD40 kg or more40 mg once per day

* An oral suspension is a type of liquid mixture.
† For reference, 1 kg is about 2.2 pounds (lb).

Dosage adjustments for Protonix

Your doctor will prescribe a dosage of Protonix based on several factors. These include:

  • the specific condition being treated
  • your age
  • other health conditions you may have

Missed dose of Protonix

Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of Protonix. They may advise you to take the missed dose. Or they may advise you to skip it and take your next dose as scheduled.

For tips on how to plan your doses of Protonix and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about Protonix and its dosage.

Is there an 80 mg daily dosage of Protonix?

Yes, the recommended daily dosage of Protonix for people who have Zollinger-Ellison syndrome or other similar stomach acid conditions is 80 milligrams (mg). But doctors prescribe it as 40 mg twice per day, for a total daily dosage of 80 mg. Doctors sometimes need to prescribe higher dosages for these conditions.

Talk with your doctor if you think you need a higher dosage of Protonix or if your current dosage isn’t working well. Don’t change your dosage without talking with your doctor. If you have questions about your Protonix dosage, ask your doctor or pharmacist.

Do I need to take Protonix before or after food?

It depends on the form of Protonix that you take. You can take Protonix oral tablet with or without food. So, you can take it before or after you eat.

For the granules for oral suspension*, you need to take it 30 minutes before a meal.

To learn more about how to take Protonix, talk with your doctor or pharmacist.

* An oral suspension is a type of liquid mixture.

Is Protonix taken long term?

Yes, you can take it long term.

At first, doctors typically prescribe Protonix as a short-term treatment to treat erosive esophagitis related to gastroesophageal reflux disease (also called acid reflux or GERD). Then, they may continue to prescribe it as a long-term treatment to maintain healing. Doctors may also prescribe Protonix as a long-term treatment for Zollinger-Ellison syndrome and other similar stomach acid conditions.

If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

If you have questions about how long you should take Protonix, talk with your doctor.

How Protonix is taken

You’ll swallow Protonix oral tablet or granules for oral suspension* once or twice per day. A healthcare professional will give you the injection form.

You can take Protonix oral tablet with or without food. For Protonix granules for oral suspension, you need to take it 30 minutes before a meal. You’ll open the packet of granules and stir it into apple juice or applesauce. Don’t use any other beverages or foods to take Protonix granules for oral suspension.

Don’t split, chew, or crush Protonix oral tablets or granules for oral suspension. If it’s hard for you to swallow tablets, view this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

* An oral suspension is a type of liquid mixture.

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Overdose of Protonix

It’s important that you do not take more Protonix than your doctor prescribes. Doing so can lead to harmful effects.

What to do if you take too much Protonix

If you think you’ve taken too much Protonix, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for Protonix. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your Protonix dosage without your doctor’s recommendation. You should take Protonix exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • Will my dosage of Protonix change if my current dosage isn’t working for my condition?
  • Will my dosage of Protonix change if I take other drugs with it?
  • How long do I need to take Protonix?
  • Would a different dosage of Protonix raise or lower my risk of side effects from the drug?

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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