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Medically Approved

Omeprazole delayed-release oral capsule vs. famotidine oral tablet: A detailed guide

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CostBrand namesUsesDosageSide effectsFAQWarningsWhat to ask
Omeprazole delayed-release (DR) oral capsule and famotidine oral tablet are prescription drugs used to treat certain stomach conditions, including ulcers and acid reflux. Although they treat similar conditions, they belong to different groups of drugs.
Medically reviewed by Beth Thomas, PharmD, RPh
Updated on

This article explains how omeprazole DR oral capsule and famotidine oral tablet are similar and different. You can view detailed articles about omeprazole DR oral capsule and famotidine oral tablet if you’d like more information about these drugs.

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Cost of omeprazole and famotidine

As with the cost of other medications, the cost of omeprazole DR oral capsule and famotidine oral tablet can vary. Their price may be affected by:

  • whether they’re covered by health insurance, if you have coverage
  • the pharmacy they’re purchased from
  • the quantity you’re prescribed

Coupons and cost savings

To view drug prices when Optum Perks coupons are applied, see this coupon page for omeprazole DR oral capsule and this coupon page for famotidine oral tablet. You can also check with your doctor, pharmacist, or insurance provider.

The options described in this article may also help you save on your prescription.

Download the free Optum Perks Discount Card to save up to 80% on some prescription medications.

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Note: Optum Perks coupons cannot be used with insurance copays or benefits.

Brand-name versions

Omeprazole DR oral capsule and famotidine oral tablet are generic medications. These drugs are not available in brand-name versions.

A generic medication is an identical copy of the active ingredient in a brand-name medication. (An active ingredient is what makes a medication work.) Generics usually cost less than brand-name drugs. And they’re thought to be as safe and effective as the brand-name versions.

Talk with your doctor or pharmacist if you have questions about generic or brand-name medications.

Uses of omeprazole and famotidine

Here’s a summary of the approved uses of omeprazole DR oral capsule and famotidine oral tablet:

 omeprazole DR oral capsulefamotidine oral tablet
Approved uses• treat ulcers in the stomach or upper part of the small intestine
• treat Helicobacter pylori (H. pylori) infection, to reduce the risk of developing another ulcer in the upper part of the small intestine
• treat heartburn and other symptoms of gastroesophageal reflux disease (GERD)
• treat and heal erosive esophagitis due to GERD
• treat certain conditions related to too much stomach acid, such as Zollinger-Ellison syndrome
• treat ulcers in the stomach or upper part of the small intestine
• reduce the risk of developing another ulcer in the upper part of the small intestine
• treat heartburn and other symptoms of GERD
• treat erosive esophagitis due to GERD
• treat certain conditions related to too much stomach acid, such as Zollinger-Ellison syndrome
Prescribed to• adults for all uses
• children ages 2 years and older for some uses
• adults for all uses
• children who weigh at least 40 kilograms (kg),* which is about 88 pounds (lb), for some uses

* 1 kg is about 2.2 lb.

Omeprazole DR oral capsule is prescribed together with other drugs, such as clarithromycin with or without amoxicillin, to treat H. pylori infection. This is to reduce the risk of another ulcer in the upper part of the small intestine.

If you’d like to know more about taking either medication for your condition, ask your doctor. They can recommend whether omeprazole DR oral capsule or famotidine oral tablet is an option to consider.

Dosage of omeprazole and famotidine

Below is dosage information for the conditions that both omeprazole DR oral capsule and famotidine oral tablet are prescribed to treat and help prevent. To find detailed dosage information for all conditions that these drugs treat and help prevent, see these articles about omeprazole DR oral capsule dosage and famotidine oral tablet dosage.

Below are dosages provided by the drugmakers of omeprazole DR oral capsule and famotidine oral tablet. If your doctor prescribes either medication, you should follow the dosage they prescribe. They’ll advise the dosage that’s best for your condition. Do not adjust your dosage without first talking with your doctor.

Omeprazole DR oral capsule’s dosage

Below is a summary of the recommended dosages of omeprazole delayed-release (DR) oral capsule for adults and children. (With delayed release, the drug is released after it leaves your stomach.)

Omeprazole DR oral capsule’s dosage in adults

Below is a summary of omeprazole DR oral capsule’s recommended dosages in adults. Strength is measured in milligrams (mg).

PurposeHow it’s taken Recommended dosage and frequencyDuration
treat stomach ulcerby mouth40 mg once per day4–8 weeks
treat ulcer in the upper part of the small intestineby mouth20 mg once per day4 weeks
treat H. pylori infection, along with other drugsby mouth20 mg twice per day or 40 mg once per day, depending on the other drugs taken with omeprazole10–14 days, with longer durations recommended for people who have an ulcer
treat symptoms of GERDby mouth20 mg once per day up to 4 weeks
treat and heal erosive esophagitis due to GERDby mouth20 mg once per day • for treatment: 4–8 weeks
• for healing: up to 12 months
treat certain conditions related to too much stomach acidby mouth60 mg once per day to start, increased as needed up to 120 mg three times per day, based on your doctor’s recommendationas long as needed

Omeprazole DR oral capsule’s dosage in children

Below is a summary of omeprazole DR oral capsule’s recommended dosages in children ages 2–16 years. Strength is measured in mg. The specific dosage is based on whether the child weighs less than 20 kilograms (kg), which is about 44 pounds (lb), or at least 20 kg. (1 kg is about 2.2 lb.)

PurposeHow it’s takenRecommended dosage and frequencyDuration
treat symptoms of GERDby mouth10 or 20 mg once per day, based on weight up to 4 weeks
treat and heal erosive esophagitis due to GERDby mouth10 or 20 mg once per day, based on weight• for treatment: 4–8 weeks
• for healing: up to 12 months

Famotidine oral tablet’s dosage in adults and children

Below is a summary of famotidine oral tablet’s recommended dosages in adults and children. Strength is measured in mg. The dosages below are for children who weigh at least 40 kg, which is about 88 lb. Doctors typically prescribe a different form of famotidine for children who weigh less than 40 kg.

PurposeHow it’s taken Recommended dosage and frequencyDuration
treat stomach ulcer in adults and children by mouth40 mg once per dayup to 8 weeks
treat ulcer in the upper part of the small intestine in adults and children by mouth40 mg once per day or 20 mg twice per dayup to 8 weeks
treat symptoms of GERD in adults and childrenby mouth20 mg twice per dayup to 6 weeks
treat erosive esophagitis due to GERD in adults and childrenby mouth20 or 40 mg twice per dayup to 12 weeks
reduce the risk of another ulcer in the upper part of the small intestine in adultsby mouth20 mg once per day 1 year or as long as needed
treat certain conditions related to too much stomach acid in adultsby mouth20 mg every 6 hours, increased as needed up to a maximum of 160 mg every 6 hours based on your doctor’s recommendationas long as needed

Side effects of omeprazole and famotidine

Omeprazole DR oral capsule and famotidine oral tablet may cause mild or serious side effects. Some of the more common mild side effects of each drug are listed below. Serious side effects of omeprazole DR oral capsule and famotidine oral tablet are also listed.

Keep in mind that your side effects may differ from those listed below. They can vary based on your overall health, any other medications you take, and your age.

This article doesn’t include all possible side effects of these medications. To find more information, you can view the prescribing information for omeprazole DR oral capsule and famotidine oral tablet. You can also check out these articles about omeprazole DR oral capsule side effects and famotidine oral tablet side effects.

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Mild side effects

Below are some of the mild side effects reported with omeprazole DR oral capsule and famotidine oral tablet:

 omeprazole DR oral capsulefamotidine oral tablet
headache
dizziness✓ 
diarrhea
constipation
abdominal pain
mild allergic reaction

Serious side effects

Below are serious side effects reported with omeprazole DR oral capsule and famotidine oral tablet:

 omeprazole DR oral capsulefamotidine oral tablet
central nervous system (CNS) side effects, such as hallucinations or seizures✓*
heart palpitations✓*
low platelet levels✓*
high liver enzyme levels✓*
changes in mental health, such as anxiety or depression✓*
ringing in the ears✓*
sexual side effects, such as impotence✓*
difficulty breathing✓*
acute tubulointerstitial nephritis (a type of kidney condition)✓*
Clostridioides difficile-related diarrhea✓*
bone fracture (bone break)✓*
severe skin reactions✓*
lupus (a type of autoimmune condition)✓*
vitamin B12 deficiency✓*
low blood magnesium level✓*
stomach polyps (growths)✓*
serious allergic reaction

* This side effect was not reported in clinical studies of omeprazole DR oral capsule, but it was reported once the drug became available for use.

With a lot of drugs, serious side effects are possible, but they’re not common. If you have serious side effects from omeprazole DR oral capsule or famotidine oral tablet, call your doctor right away. If your symptoms are severe or you’re having a medical emergency, call 911 or a local emergency number.

Questions about omeprazole and famotidine

Below, you’ll find answers to some common questions about omeprazole DR oral capsule and famotidine oral tablet.

Is omeprazole or famotidine the safer treatment option?

It depends. Whether omeprazole or famotidine is safer for you varies based on factors such as:

  • the condition you’re taking the drug for
  • your age, other medical conditions, and other medications you take
  • how long you’ll need to take the drug

Either drug may have possible mild or serious side effects. And doctors may not recommend either of them if you have certain factors affecting your health. These are referred to as a drug’s warnings.

But not treating certain conditions can also have risks. For example, not treating an ulcer could lead to serious problems, such as bleeding, infection, or a blockage.

If you have questions about whether omeprazole or famotidine is a safer option for you, talk with your doctor or pharmacist. They can give you more specific advice based on your health. For details about the side effects of omeprazole or famotidine, see the “Side effects of omeprazole and famotidine” section above. For information about the warnings of these drugs, see the “Warnings for omeprazole and famotidine” section below.

Can I take omeprazole and famotidine together?

Doctors usually do not recommend taking omeprazole and famotidine together. This is because combining them may not give added benefits, especially in the long term.

Omeprazole is in a group of drugs known as proton pump inhibitors. Famotidine is in a group of drugs known as H2 blockers. Doctors use both drugs to treat similar conditions and reduce acid in the stomach. But they work differently. They also have some different side effects and warnings.

If you find that one of these drugs isn’t treating your condition well enough, talk with your doctor or pharmacist. They can discuss the risks and benefits of omeprazole and famotidine. They can also recommend the best way to take either medication so they effectively treat your condition.

Between omeprazole DR oral capsule and famotidine oral tablet, is one a better treatment for ulcers?

Doctors may prescribe either omeprazole DR oral capsule or famotidine oral tablet to treat ulcers in the stomach or upper part of the small intestine. In studies, omeprazole DR oral capsule and famotidine oral tablet were each effective for this purpose.

That said, these medications differ in some ways. For instance, they:

  • work in different ways to reduce acid in the stomach
  • may have different side effects and warnings
  • come in different forms
  • may have different dosing schedules
  • doctors may prescribe them to different age groups

Keep in mind that your results from taking omeprazole DR oral capsule or famotidine oral tablet may differ from those seen in studies.

Your doctor can help determine whether one option is better for your condition. They’ll recommend this based on your specific needs and health factors. Talk with your doctor if you’d like to learn more about which drug is right for you.

Warnings for omeprazole and famotidine

Some medications may not be recommended for you if you have certain factors affecting your health. These are referred to as a drug’s warnings.

Some people should not take omeprazole DR oral capsule or famotidine oral tablet, and others should take either medication with caution. Before taking either medication, talk with your doctor about your health conditions, past surgeries, and any medications you take. Your doctor can recommend whether either drug is safe for you.

Warnings for omeprazole DR oral capsule and famotidine oral tablet are summarized in the table below:

 omeprazole DR oral capsulefamotidine oral tablet
CNS side effects, such as confusion, delirium, hallucinations, and seizures
QT prolongation, which could lead to irregular heart rhythm
acute tubulointerstitial nephritis  
Clostridioides difficile-related diarrhea
bone fracture
severe skin reactions
lupus
vitamin B12 deficiency
low blood magnesium level
stomach polyps
taking rilpivirine, clopidogrel, St. John’s wort, rifampin, or methotrexate
allergic reaction to either drug or any of their ingredients ✓ ✓

You can view more detailed articles about omeprazole DR oral capsule and famotidine oral tablet if you’d like to know more about warnings for these drugs. You can also view the prescribing information for omeprazole DR oral capsule and famotidine oral tablet.

What to ask a doctor

If you’re trying to decide whether omeprazole DR oral capsule or famotidine oral tablet is better for you, talk with your doctor. They can recommend the best option.

Here’s a list of questions you may want to ask your doctor:

  • Does omeprazole or famotidine interact with any other drugs I’m taking?
  • Would omeprazole or famotidine be a better choice for me based on my health factors?
  • How long should it take before I feel a difference by taking omeprazole or famotidine?

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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