This article describes possible interactions with metaxalone oral tablet. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.
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Other drugs and metaxalone
The drugs in the list below may interact with metaxalone oral tablet. This article doesn’t include all drugs that may interact with metaxalone.
Drug classes or drugs that may interact with metaxalone oral tablet include:
- benzodiazepines:
- drug examples: clonazepam (Klonopin), alprazolam (Xanax)
- what might happen: can increase the risk of side effects of metaxalone and the benzodiazepine
- monoamine oxidase inhibitors (MAOIs):
- drug examples: tranylcypromine (Parnate), selegiline (Emsam)
- what might happen: can increase the risk of side effects of metaxalone and the MAOI
- opioids:
- selective serotonin reuptake inhibitors (SSRIs):
- drug examples: sertraline (Zoloft), paroxetine (Paxil, others)
- what might happen: can increase the risk of side effects of metaxalone and the SSRI
- serotonin-norepinephrine reuptake inhibitors (SNRIs):
- drug examples: duloxetine (Cymbalta), venlafaxine (Effexor XR)
- what might happen: can increase the risk of side effects of metaxalone and the SNRI
- tricyclic antidepressants (TCAs):
- drug examples: amitriptyline, nortriptyline (Pamelor)
- what might happen: can increase the risk of side effects of metaxalone and the TCA
- triptans:
- drug examples: rizatriptan (Maxalt, others), sumatriptan (Imitrex, others)
- what might happen: can increase the risk of side effects of metaxalone and the triptan
- diphenhydramine (Benadryl):
- what might happen: can increase the risk of side effects of metaxalone and diphenhydramine
- mirtazapine (Remeron):
- what might happen: can increase the risk of side effects of metaxalone and mirtazapine
- trazodone:
- what might happen: can increase the risk of side effects of metaxalone and trazodone
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Get free cardWhen to avoid metaxalone
Certain health conditions or other factors could increase some risks with metaxalone oral tablet. Because of this, doctors may not prescribe metaxalone in these cases. These health conditions or other factors are called contraindications.
Here’s a list of contraindications for metaxalone oral tablet:
- Severe kidney or liver condition: If you have a severe kidney or liver condition, you’re at higher risk of side effects if you take metaxalone.
- Anemia, including as a side effect from another medication: If you have anemia, or if you’ve had anemia as a side effect from taking a medication in the past, taking metaxalone oral tablet may cause your anemia to worsen or symptoms to return. You may also be at higher risk of hemolytic anemia as a side effect of metaxalone.
- Past allergic reaction to metaxalone: If you’ve ever had an allergic reaction to metaxalone oral tablet, taking it again may cause another allergic reaction.
Before you start taking metaxalone, ask your doctor about metaxalone warnings and contraindications. Your doctor can recommend whether you should take this drug.
Alcohol and metaxalone
Metaxalone oral tablet is known to interact with alcohol.
Taking metaxalone oral tablet and drinking alcohol may cause or worsen certain side effects, such as:
- drowsiness
- problems with balance, coordination, and decision making
- slow, shallow breathing
If you drink alcohol and have concerns about metaxalone interactions with alcohol, talk with your doctor before you start treatment with the drug.
Questions about metaxalone and interactions
Here, you’ll find answers to common questions about metaxalone and possible interactions.
Are there interactions between metaxalone and ibuprofen?
No, metaxalone and ibuprofen aren’t known to interact. Interactions between these medications haven’t been reported.
Metaxalone is a muscle relaxer you use for short-term relief of muscle pain and discomfort. Your doctor may also prescribe ibuprofen together with metaxalone to treat symptoms of muscle pain.
Ask your doctor or pharmacist if you have more questions about taking metaxalone and ibuprofen together.
Does cyclobenzaprine have similar interactions as metaxalone?
Yes, cyclobenzaprine and metaxalone share many drug interactions. For example, both medications may interact with:
- opioids such as tramadol (Conzip, others)
- alcohol
- benzodiazepines, such as alprazolam (Xanax)
Metaxalone and cyclobenzaprine are both muscle relaxer drugs. They may be used for short-term relief of muscle pain and stiffness.
Talk with your doctor or pharmacist if you’d like to learn more about how metaxalone and cyclobenzaprine compare.
Other interactions and metaxalone
Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether metaxalone oral tablet has these interactions.
The information below doesn’t include all other possible interactions possible with metaxalone.
Metaxalone and supplements
Before taking metaxalone oral tablet, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Metaxalone interactions with herbs
Metaxalone oral tablet may interact with St. John’s wort. People use this herb to help relieve symptoms of depression. Using metaxalone and St. John’s wort together may increase the risk of serotonin syndrome as a side effect. (With this condition, serotonin builds up in your body.)
Because of this, ask your doctor or pharmacist before taking any of these products while taking metaxalone oral tablet.
Metaxalone interactions with vitamins
Metaxalone oral tablet isn’t known to interact with any vitamins. But this doesn’t mean interactions with vitamins can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before taking any of these products while using metaxalone oral tablet.
Metaxalone and food
Metaxalone oral tablet isn’t known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist about what foods you should avoid while using metaxalone oral tablet.
Metaxalone and vaccines
Metaxalone oral tablet isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before receiving any vaccines while taking metaxalone oral tablet.
Metaxalone and lab tests
Metaxalone oral tablet may interact with a certain test used to check for glucose (sugar) in the urine. Having sugar in your urine is typically a sign of very high blood sugar levels.
Taking metaxalone can cause a false-positive result on this test. (A false-positive result means the test result may show glucose in your urine when there isn’t any.)
Because of this, talk with your doctor or pharmacist before having any tests while taking metaxalone oral tablet.
Metaxalone and cannabis or CBD
Reports have shown cannabis (commonly called marijuana) and cannabis products may interact with metaxalone. Cannabidiol (CBD) is an example of a cannabis product.
Taking metaxalone and cannabis or cannabis products may increase the risk of side effects, including drowsiness and difficulties with balance, coordination, or decision making.
Before you take metaxalone, tell your doctor and pharmacist if you use cannabis. Doing so may help prevent possible interactions.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Health factors and metaxalone
Certain medical conditions or other health factors may increase the risk of interactions with metaxalone oral tablet. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking metaxalone, tell your doctor about your health history. They’ll determine whether metaxalone is right for you.
These health conditions or other factors might interact with metaxalone oral tablet:
- kidney conditions, such as chronic kidney disease
- liver conditions, such as cirrhosis
- pregnancy or breastfeeding
- past allergic reaction to metaxalone
Preventing metaxalone interactions
You may be able to help avoid certain interactions with metaxalone oral tablet. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.
Things to consider include:
- Whether you drink alcohol or use cannabis.
- Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
- What to do if you’re prescribed a new drug while using metaxalone oral tablet.
Taking metaxalone exactly as prescribed can also help prevent interactions.
What to ask your doctor
If you have questions about metaxalone and possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Should I take my medications at different times of the day to help avoid interactions?
- Do other drugs that could treat my condition have similar interactions?
- Could I still take metaxalone even if it interacts with a health condition I have?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.