This article describes imiquimod topical cream’s dosages and strength and gives details on how to use it. You’ll also find information on cost savings and coupon options for imiquimod. If you want to know more about imiquimod topical cream, talk with your doctor or pharmacist.
Imiquimod topical cream is a generic version of the brand-name drug Zyclara.
Form and strength of imiquimod
Imiquimod topical cream comes as follows:
- Form: cream that you apply to the affected area of your skin
- Strength: 3.75%
The cream is available in packets and in a pump.
Dosage of imiquimod
This article describes the recommended dosages for imiquimod topical cream. The drugmaker provides these dosages.
If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of imiquimod topical cream without your doctor’s recommendation.
Usual recommended dosages of imiquimod in adults
Imiquimod topical cream is approved to treat actinic keratosis and external genital warts or perianal warts in adults. The table below shows the dosages and treatment plan.
| Condition | Recommended dosage | Treatment plan |
| actinic keratosis | Apply a thin film once daily to the affected skin. | • Weeks 1 and 2: use recommended dosage daily at bedtime • Weeks 3 and 4: do not use • Weeks 5 and 6: use recommended dosage daily at bedtime |
| external genital warts or perianal warts* | Apply a thin film once daily to the affected skin. | Use recommended dosage daily at bedtime until warts are gone or for a maximum of 8 weeks. |
* “Perianal” involves the tissues surrounding the anus.
Dosages of imiquimod in children
Imiquimod topical cream is approved to treat external genital warts or perianal warts in children ages 12 years and older. Children’s recommended dosage is as follows:
- Dosage: Apply a thin film once daily to the affected skin. The maximum dose is up to one packet or one pump.
- Treatment plan: Use recommended dosage daily at bedtime until warts are gone or for a maximum of 8 weeks.
Missed dose of imiquimod
Talk with your doctor or pharmacist right away if you realize you forgot to apply a dose of imiquimod topical cream. They may advise you to apply the missed dose. Or they may advise you to skip it and apply your next dose as scheduled.
For tips on how to plan your doses of imiquimod topical cream and avoid missing a dose, read this article. You could also try:
- downloading a reminder app on your phone
- setting an alarm
- putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table
Frequently asked questions
Below are answers to some commonly asked questions about imiquimod topical cream and its dosage.
Can imiquimod be used for basal cell carcinoma? If so, what’s the dosage?
Imiquimod is not approved for basal cell carcinoma (BCC). But your doctor might prescribe it off-label for this use. With off-label use, doctors prescribe a drug for a purpose other than what it’s approved to treat or prevent.
If you have questions about BCC or imiquimod’s dosage, talk with your doctor.
Is imiquimod used long term?
No, doctors don’t typically prescribe imiquimod topical cream as a long-term treatment. Instead, it’s usually recommended for short-term use.
If you have questions about how long you should use imiquimod topical cream, talk with your doctor.
How imiquimod is used
You’ll apply imiquimod topical cream to your affected skin once per day.
Dab the cream onto the affected area, and rub it in gently until it’s no longer visible. Allow the cream to stay on your skin for about 8 hours. After that, wash the area with soap and water.
Your doctor may advise that you use this medication at bedtime each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

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Overdose of imiquimod
It’s important that you do not use more imiquimod topical cream than your doctor prescribes. Doing so can lead to harmful effects.
Symptoms of imiquimod overdose
Symptoms of an overdose can include:
- increased skin irritation
- low blood pressure
What to do if you use too much imiquimod
If you think you’ve used too much imiquimod, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.
What to ask your doctor
This article describes the usual recommended dosages for imiquimod topical cream. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.
Do not change your dosage of imiquimod topical cream without your doctor’s recommendation. You should use imiquimod topical cream exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.
Here’s a list of some possible questions you may want to ask your doctor:
- Will my dosage of imiquimod topical cream be changed if my current dosage isn’t working for my condition?
- Will a different dosage of imiquimod topical cream raise or lower my risk of side effects from the drug?
- Does my dosage of imiquimod topical cream need to be adjusted if I’m taking other drugs with it?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.