Cholestyramine is commonly used to treat hyperlipidemia (high cholesterol) and itching caused by partial bile obstruction.
It comes in the form of a powder that is mixed with liquid or food to form an oral suspension.
Cholestyramine is not available over the counter and requires a prescription from a healthcare professional. Cholestyramine is a generic drug, but it comes in brand-name versions like Locholest, Locholest Light, and Prevalite.
What foods should I avoid while taking cholestyramine?
No foods are dangerous to eat while taking cholestyramine, and most foods will not affect how the drug works. However, some foods can potentially make it less effective, mostly due to their high cholesterol content. Some foods may increase your risk of side effects, such as diarrhea, constipation, nausea, heartburn, gas, and bloating, when you eat them with cholestyramine.
Because of this, you may want to avoid some foods while taking cholestyramine, such as:
- High fat foods: High fat foods like pizza, fried food, processed meats, and chips are typically high in cholesterol. Since you will take cholestyramine to reduce cholesterol, you’d probably want to avoid these foods while taking the drug. Also, high fat foods can increase how much bile acid your body produces. Since cholestyramine works by binding to bile acids, this may affect how effective the drug is. High fat foods may also increase your risk of side effects while taking cholestyramine.
- Dairy products: Full-fat dairy may cause cholestyramine to be less effective since it tends to be high in cholesterol. Dairy foods may also increase the risk of common side effects like constipation and bloating. Because of this, it’s best to avoid full-fat dairy like cheese and milk.
- Foods fortified with vitamins and minerals: Foods with added vitamins, such as certain cereals and juices, may interact with cholestyramine, decreasing its absorption and effectiveness. Keep an eye out for foods with added folate or vitamin K.
- Spicy foods: Spicy foods won’t affect how cholestyramine works. But they can make side effects like nausea, vomiting, and heartburn worse.
Can you drink coffee when taking cholestyramine?
It is generally safe to drink coffee while taking cholestyramine. Coffee itself does not have a significant impact on the effectiveness of cholestyramine or its side effects.
However, research may suggest that drinking a certain amount of coffee could be related to a higher risk of dyslipidemia. Dyslipidemia refers to an atypical level of lipids (fats) in the blood, including cholesterol.
How long should I wait to eat after taking cholestyramine?
You do not need to wait a certain amount of time after eating to take your cholestyramine dose. Instead, it is recommended that you take this drug with meals.
Taking cholestyramine with food and drink may help reduce your risk of certain gastrointestinal side effects. Taking it with food also helps it to work properly. Cholestyramine works by binding to bile acids in your intestines to lower cholesterol levels. Your body creates these bile acids during digestion.
It’s also important to remember that cholestyramine is a suspension that you must mix with food or liquid. You may choose to mix cholestyramine with water, juice, other non-carbonated drinks, applesauce, pulpy fruits (such as crushed pineapple), or thin soups.
Avoid mixing Cholestyramine with soda or sparkling water. These drinks can make the powder foam, making it harder to swallow, and can cause extra gas or bloating.

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Although no specific foods are dangerous to eat while taking cholestyramine, some foods may make it less effective or increase your risk of side effects. For this reason, you may want to avoid foods high in cholesterol, high fat foods, full-fat dairy products, vitamin-fortified foods, and possibly spicy foods. These foods will likely increase your risk of side effects like nausea, heartburn, diarrhea, gas, and bloating.
Cholestyramine works best when you eat a diet low in cholesterol. You should always mix it with food or liquid before taking it.