This article describes Entresto’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for Entresto. If you want to know more about Entresto, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.
Entresto is a brand-name medication that comes as a tablet that you swallow. It isn’t available in a generic version. This article describes dosages of Entresto.
Entresto has a boxed warning. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the end of this article.
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Form and strengths of Entresto
Entresto is a combination of two medications, sacubitril and valsartan. Strengths are listed in milligrams (mg), with the strength of sacubitril listed first and the strength of valsartan listed second. The form and strengths of Entresto are as follows:
- Form: tablet that you swallow
- Strengths: 24 mg sacubitril/26 mg valsartan, 49 mg sacubitril/51 mg valsartan, 97 sacubitril/103 mg valsartan
In certain situations, your doctor may prescribe Entresto oral suspension (a type of liquid mixture). The pharmacy will prepare the oral suspension using Entresto 49 mg sacubitril/51 mg valsartan tablets.
Dosage of Entresto
This article describes the recommended dosages for Entresto. The drugmaker provides these dosages. In some cases, doctors may adjust your dosage from those shown below.
If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of Entresto without your doctor’s recommendation.
Usual recommended dosages of Entresto in adults
Entresto is prescribed to reduce the risk of hospitalization and death related to heart failure in adults with heart failure.
Usually, doctors start by prescribing a low dosage of Entresto. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of Entresto that gives the desired outcome.
- Starting dosage: Entresto 49 mg sacubitril/51 mg valsartan twice per day
- Maintenance dosage: Entresto 97 mg sacubitril/103 valsartan mg twice per day
- Maximum dosage: Entresto 97 mg sacubitril/103 mg valsartan twice per day
Your doctor may prescribe an Entresto oral suspension (type of liquid mixture) if you’re unable to swallow tablets. The pharmacy will prepare the oral suspension using Entresto 49 mg sacubitril/51 mg valsartan oral tablets. You’ll take the same dosage of Entresto as you would if you were taking Entresto oral tablets.
Dosages of Entresto in children
Entresto is prescribed to treat certain types of heart failure in children ages 1 year or older. The doctor may increase your child’s dose of Entresto as quickly as every 2 weeks. Typically, your child will start by taking a low dosage of Entresto for 2 weeks. Then, your child will take a second, higher dosage for 2 weeks. If this dosage is tolerated, your child’s dosage will then be adjusted to a final higher dose level. Doses of Entresto should be taken two times per day. The usual dosage schedule is as follows:
| Weight in (kg) | Weight in (lb) | Starting dose level | Second dose level | Final and maximum dose level | Frequency |
|---|---|---|---|---|---|
| less than 40 kg | less than 88 lb | 1.6 mg/kg | 2.3 mg/kg | 3.1 mg/kg | two times per day |
| 40 kg to less than 50 kg | 88 lb to less than 110 lb | 24 mg sacubitril/26 mg valsartan | 49 mg sacubitril/51 mg valsartan | 72 mg sacubitril/78 mg valsartan | two times per day |
| 50 kg or greater | 110 lb or greater | 49 mg sacubitril/51 mg valsartan | 72 mg sacubitril/78 mg valsartan | 97 mg sacubitril/103 mg valsartan | two times per day |
Your doctor will likely prescribe an Entresto oral suspension (a type of liquid mixture) if your child weighs less than 40 kg (less than 88 lb). Your doctor also may prescribe an Entresto oral suspension if your child is unable to swallow tablets, or if oral tablets are not available in a strength that matches the prescribed dose.
The pharmacy will prepare the oral suspension using Entresto 49 mg sacubitril/51 mg valsartan oral tablets. The recommended doses of the oral suspension in mg/kg represent the combined amount of both sacubitril and valsartan.
Frequently asked questions
Below are answers to some commonly asked questions about Entresto and its dosage.
What should I do for a missed dose of Entresto?
If you realize you forgot to take a dose of Entresto, take it as soon as you remember. If it’s close to your next dose, skip your missed dose. You should not take two doses at once. This could lead to low blood pressure.
If you’ve missed a dose and are uncertain about what to do, tell your doctor or pharmacist right away. They may advise you to take the missed dose. Or they may advise you to skip it and take your next dose as scheduled.
For tips on how to plan your doses of Entresto and avoid missing a dose, read this article. You could also try:
- downloading a reminder app on your phone
- setting an alarm
- putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table
Can Entresto tablets be cut in half?
Cutting Entresto tablets in half has not been studied or approved by the FDA. Entresto contains two different drugs. Splitting a tablet in half may result in uneven amounts of each drug. If you have difficulty swallowing tablets, your pharmacy can use Entresto tablets to make an oral suspension (a type of liquid mixture) of the drug.
Speak with your doctor or pharmacist to learn more about your dosage options.
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Get free cardOverdose of Entresto
It’s important that you do not take more Entresto than your doctor prescribes. Doing so can lead to harmful effects.
Symptoms of Entresto overdose
The most likely symptom of an overdose is low blood pressure.
What to do if you take too much Entresto
If you think you’ve taken too much Entresto, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.
Boxed warning for Entresto
Entresto has a boxed warning for the risk of fetal harm during pregnancy. A boxed warning is the most serious warning from the FDA.
Risk of fetal harm: Taking Entresto while pregnant can cause fetal harm. It could damage the kidneys of the developing fetus and potentially lead to fetal death. It may also increase the risk of illness or death in the newborn. If you find out you’re pregnant while taking Entresto, stop taking the drug and speak with your doctor immediately. They may recommend a different drug for your heart failure.
You can talk with your doctor to learn more about this warning.
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.