Key takeaways
- Zyrtec is a second-generation antihistamine, while Xyzal is a newer, third-generation version. This makes Xyzal less likely to cause drowsiness for most patients.
- Experts specifically recommend taking Xyzal in the evening to manage potential sedation, whereas Zyrtec offers more flexibility and can be taken at any time of day.
- While Xyzal is primarily available as a tablet or oral solution, Zyrtec offers a wider range of formats, including liquid gels, chewables, and dissolvable tablets.
Overview
Xyzal (levocetirizine) and Zyrtec (cetirizine) are both medications that belong to the drug class of antihistamines, which means they’re both used to manage allergy symptoms. These medications are very similar, but they have several key differences, including in their active ingredient and dosage timing.
If you aren’t sure which medication will be right for you, consider reaching out to a healthcare professional, who will be able to guide you in your treatment journey.
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Xyzal vs. Zyrtec: Differences at a glance
While Xyzal and Zyrtec are both common allergy treatments, they do have several differences that we’ll look into in more depth later in the article. These differences include:
- Active ingredient: The active ingredient is what makes a drug work. Xyzal contains levocetirizine, whereas Zyrtec contains cetirizine. While similar, these two ingredients are different and can have slightly different effects.
- Type of antihistamine: Zyrtec is called a second-generation antihistamine, whereas Xyzal is a newer third-generation antihistamine.
- Side effects: Both drugs may cause similar side effects, but Xyzal may be slightly less likely than Zyrtec to cause drowsiness.
- Typical timing: Experts recommend taking Xyzal in the evening, but Zyrtec can be taken at any time of day.
Xyzal and Zyrtec forms and dosage
Here’s an overview of Xyzal and Zyrtec’s dosages and how you would take these drugs for allergies.
| Xyzal | Zyrtec | |
|---|---|---|
| Forms | – oral tablets – oral solution | – oral tablets – liquid gels – liquid suspension – dissolvable tablets – chewable tablets |
| Active ingredient | levocetirizine | cetirizine |
| Strengths | tablets: 5 milligrams (mg) oral solution: 0.5 mg per milliliter (mL) | tablet forms: 2.5 mg, 5 mg, and 10 mg liquid forms: 5 mg/5 mL |
| Adult dose | tablets: 5 mg per day oral solution: 10 mL per day | tablet forms: 5 or 10 mg per day liquid forms: 5 or 10 mL per day |
| Frequency | once per day, in the evening | once per day |
Can Xyzal and Zyrtec be used in children?
Both Xyzal and Zyrtec are approved for use in some children. The liquid forms are generally recommended for younger patients, and the dosages will be different than those for adults. Speak with a doctor for more information
Xyzal oral solution can be used in children older than 6 months, while the tablets can be taken in children older than 6 years. Zyrtec liquid forms can be given to children older than 1 year if prescribed by a doctor, while the tablets can be taken by children older than 6 years.
Side effects of Xyzal and Zyrtec
Like any medication, both Xyzal and Zyrtec may cause certain side effects. Because the drugs belong to the same class, their side effects tend to be similar.
The following shows the most common side effects of Xyzal and Zyrtec.
| Xyzal | Zyrtec | |
|---|---|---|
| Drowsiness | ✓ | ✓ |
| Fatigue | ✓ | ✓ |
| Dry mouth | ✓ | ✓ |
| Sore throat | ✓ | ✓ |
The main difference between the side effects of Xyzal and Zyrtec is the likelihood of them occurring for each medication.
This table may not include all side effects of these drugs. For more information on mild side effects, see the Xyzal prescribing information and Zyrtec prescribing information. If you have severe side effects, seek medical advice. If you think you’re having a medical emergency, call 911 or your local emergency number.
Xyzal vs. Zyrtec for drowsiness
Zyrtec is considered a second-generation antihistamine, and Xyzal is a third-generation antihistamine. These medications are classified by how likely they are to reach the brain and cause drowsiness.
First-generation antihistamines, such as diphenhydramine (Benadryl), are the most likely to enter the brain and affect your nervous system. This makes them more likely to result in drowsiness and sedation.
Second-generation drugs like Zyrtec are less likely to reach the brain or be sedating, and third-generation antihistamines like Xyzal are the least likely. However, they can all still make you feel tired.
Effectiveness of Xyzal and Zyrtec
Xyzal and Zyrtec are both used to manage allergy symptoms in adults and some children. Studies of Xyzal and Zyrtec have shown that both drugs are effective for this use.
It’s important to note that your results from Xyzal or Zyrtec may differ from those seen in studies. Talk with your doctor about whether one of these drugs is right for you.
Cost of Xyzal and Zyrtec
Whether you have health insurance or not, cost may be a factor when you’re considering these drugs. Keep in mind that what you’ll pay for either drug will depend on your treatment plan, health insurance, and the pharmacy you use.
Xyzal and Zyrtec are both brand-name drugs. These drugs also have generic forms: levocetirizine and cetirizine, respectively. You’ll usually pay more for brand-name drugs than generics. If you’re interested in using the generic form of either drug, talk with your doctor.
If you don’t have insurance, you can also look into discount cards and coupons for the medications, such as the Optum Perks coupon for Zyrtec.
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Get free cardHow to choose between Xyzal and Zyrtec
Xyzal and Zyrtec each have benefits and drawbacks, and the right medication for you will depend on your individual condition, lifestyle, and preferences. If you need advice, consider reaching out to a healthcare professional to help you decide.
Here are some factors you may consider:
- Lifestyle: It’s recommended to take Xyzal in the evening, which can help you establish a stronger routine. Zyrtec can be taken at any time, which may offer more flexibility.
- Side effects: Both medications may cause side effects, but the likelihood of you experiencing these effects may be different for each drug. Xyzal is a newer medication that is less likely to cause drowsiness.
- Drug form and dosage: Zyrtec comes in more forms than Xyzal. It also comes in a stronger dose.
Summary
Ultimately, choosing between Xyzal (levocetirizine) and Zyrtec (cetirizine) often comes down to your personal sensitivity to side effects and your daily routine.
Because both medications are effective for managing seasonal allergies and hives, the “best” choice is the one that aligns with your condition and lifestyle. If you have underlying health conditions or are choosing a medication for a young child, consulting a healthcare professional is the best way to ensure a safe and effective treatment journey.
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Disclaimer: While Optum Perks strives for factual, comprehensive, and current information, this article is not a substitute for a licensed healthcare professional’s expertise. Always consult a doctor before taking or discontinuing any medication. Drug information is subject to change and may not cover all uses, directions, precautions, warnings, interactions, reactions, or adverse effects. The lack of a warning does not guarantee a drug’s safety, effectiveness, or appropriateness for all patients or specific uses.