Omeprazole DR oral capsule interactions

This article describes possible interactions with omeprazole DR oral capsule. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.

Omeprazole comes as a delayed-release (DR) capsule that you’ll swallow. “Delayed release” means the drug releases into your body slowly over time. This form of omeprazole is available by prescription only. Omeprazole is also available in an over-the-counter version as tablets, capsules, and dissolvable tablets. The interactions and uses of omeprazole may vary depending on the form of omeprazole your doctor prescribed.

Need a diagnosis or prescription quickly? For certain health conditions, Optum Perks offers personalized on-demand care with no appointment required. For $25, answer a few questions online and receive a diagnosis and treatment plan from a board certified healthcare professional in 15 minutes or less. Get started here.

Other drugs and omeprazole

The drugs in the list below may interact with omeprazole DR oral capsule. This article doesn’t include all drugs that may interact with omeprazole.

Drug classes or drugs that may interact with omeprazole DR oral capsule include:

• certain HIV medications:
  • drug examples: atazanavir (Reyataz), rilpivirine (Edurant)
  • what might happen: can make the HIV medication less effective or increase the risk of side effects of the HIV medication
• certain diuretics:
  • drug examples: hydrochlorothiazide, chlorthalidone (Thalitone)
  • what might happen: can increase the risk of hypomagnesemia (low blood magnesium levels)
• warfarin (Coumadin):
  • what might happen: can affect the rate at which your blood clots, which may lead to increased bleeding
• methotrexate (Trexall):
  • what might happen: can increase the risk of side effects of methotrexate
• clopidogrel (Plavix):
  • what might happen: can make clopidogrel less effective
• citalopram (Celexa):
  • what might happen: can increase the risk of QT prolongation (a type of irregular heart rhythm)
• phenytoin:
  • what might happen: can increase the risk of side effects of phenytoin
• digoxin (Lanoxin):
  • what might happen: can increase the risk of side effects of digoxin
• mycophenolate mofetil (Cellcept):
  • what might happen: can make mycophenolate less effective
• rifampin (Rifadin):
  • what might happen: can make omeprazole less effective

Download the free Optum Perks Discount Card to save up to 80% on some prescription medications.

Questions about omeprazole and interactions

Here you’ll find answers to some common questions about omeprazole and possible interactions.

Can you take omeprazole with blood pressure medicine?

Yes, if recommended by your doctor. Omeprazole DR oral capsule typically doesn’t interact with most blood pressure medications.

However, omeprazole can interact with certain diuretics (water pills). Taking omeprazole and these diuretics together can increase your risk of hypomagnesemia (low blood magnesium levels).

Before starting any new drugs, talk with your doctor or pharmacist to make sure they are safe to take with your current medications.

Are there any omeprazole interactions with antibiotics?

Yes. Omeprazole DR oral capsule may interact with certain antibiotics, such as rifampin (Rifadin) and cefuroxime.

The effect of these interactions depends on the antibiotic. Taking rifampin and omeprazole together can make omeprazole less effective. But taking cefuroxime and omeprazole together can make cefuroxime less effective.

Before starting an antibiotic, talk with your doctor to see if it’s safe to take with omeprazole.

Other interactions and omeprazole

Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether omeprazole DR oral capsule has these interactions. 

The information below doesn’t include all other possible interactions with omeprazole.

Omeprazole and supplements

Before taking omeprazole DR oral capsule, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Omeprazole and herbs

Omeprazole DR oral capsule may interact with St. John’s wort. Some people use this herb to ease symptoms of depression.

Taking omeprazole and St. John’s wort can make omeprazole less effective for your condition.

Because of this, ask your doctor or pharmacist before taking any of these products while taking omeprazole DR oral capsule.

Omeprazole and vitamins

Omeprazole DR oral capsule isn’t known to interact with any vitamins. But this doesn’t mean interactions with vitamins can’t happen or won’t be identified later.

If you have more questions about omeprazole interactions with vitamins, talk with your doctor.

Omeprazole and food

It’s important that you take omeprazole DR oral capsule before a meal. If you take omeprazole with your meal, an interaction could occur that lowers the level of the drug in your body. This may make omeprazole less effective for your condition.

If you have more questions about omeprazole interactions with food, talk with your doctor.

Omeprazole and vaccines

Omeprazole DR oral capsule isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist before receiving any vaccines while taking omeprazole DR oral capsule.

Omeprazole and lab tests

Omeprazole DR oral capsule may interact with a serum chromogranin A (CgA) test. This is a blood test used to check for neuroendocrine tumors (a type of tumor that causes your body to release hormones into your blood). Taking omeprazole and having this test may lead to false-positive results.

Omeprazole may also interact with a secretin stimulation test. This test determines how well your pancreas is functioning. Taking omeprazole and having this test may cause inaccurate results.

Omeprazole may also interact with a urine test used to check for tetrahydrocannabinol (THC). Taking omeprazole and having this test may lead to false-positive results.

Because of this, talk with your doctor or pharmacist before having any tests while taking omeprazole DR oral capsule.

Omeprazole and cannabis or CBD

Studies of cannabis (commonly called marijuana) and cannabis products have shown cannabis to interact with omeprazole. Cannabidiol (CBD) is an example of a cannabis product.

Taking omeprazole and cannabis may increase your risk of side effects of omeprazole.

Before you take omeprazole, tell your doctor and pharmacist if you use cannabis. Doing so may help prevent possible interactions.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

When to avoid omeprazole

Certain health conditions or other factors could increase some risks with omeprazole DR oral capsule. Because of this, doctors may not prescribe omeprazole in these cases. These health conditions or other factors are called contraindications.

Here’s a list of omeprazole contraindications:

• Taking drugs that contain rilpivirine: If you take any drugs that contain rilpivirine, taking omeprazole oral capsule DR may cause rilpivirine to be less effective.
• Past allergic reaction to omeprazole: If you’ve ever had an allergic reaction to omeprazole DR oral capsule, taking it again may cause another allergic reaction.

Before you start taking omeprazole, talk with your doctor about the contraindications of omeprazole. They can recommend whether you should take it.

Alcohol and omeprazole

Omeprazole DR oral capsule is not known to interact with alcohol. But drinking alcohol while taking omeprazole can increase your risk of certain side effects. These include nausea, headache, and diarrhea.

Drinking alcohol can also worsen some of the conditions omeprazole is used to treat, such as gastroesophageal reflux disease (GERD).

If you have more questions about omeprazole interactions with alcohol, talk with your doctor.

Health factors and omeprazole

Certain medical conditions or other health factors may increase the risk of interactions with omeprazole DR oral capsule. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking omeprazole, tell your doctor about your health history. They’ll determine whether omeprazole is right for you.

These health conditions or other factors might interact with omeprazole DR oral capsule:

• liver problems
• low magnesium, calcium, or potassium levels in your blood
• osteoporosis
• Asian heritage
• lupus
• pregnancy or breastfeeding
• past allergic reaction to omeprazole

Preventing omeprazole interactions

You may be able to help avoid certain interactions with omeprazole DR oral capsule. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.

Things to consider include:

• Whether you drink alcohol or use cannabis.
• Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
• What to do if you’re prescribed a new drug while taking omeprazole DR oral capsule.

Taking omeprazole exactly as prescribed can also help prevent interactions.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.