Poison ivy is a plant that grows in North America. You may develop an allergic reaction if your skin comes into contact with its leaves, stems, or roots.
An allergic reaction can develop in response to urushiol, an oily resin present in poison ivy. Certain other plants also produce urushiol, including poison oak and poison sumac.
Mupirocin is an antibiotic available as a topical (you apply it on your skin) cream or ointment. Healthcare professionals use Mupirocin to treat bacterial skin infections.

Does mupirocin work for poison ivy?
Mupirocin is an antibiotic. It isn’t an effective treatment for poison ivy rash because the rash you develop from exposure to the plant is an allergic reaction and not a bacterial infection.
Other medications are available that doctors prescribe for the treatment of an itchy skin rash caused by exposure to poison ivy.
Need a diagnosis or prescription quickly? Optum Perks offers personalized on-demand care in as little as 15 minutes. For $29, answer a few questions online and receive a diagnosis and treatment plan from a US-licensed healthcare professional. Get started here.
What medications are most effective for poison ivy?
A skin rash caused by exposure to poison usually goes away on its own, but it can take weeks to resolve. Treatments for poison ivy rash aim to relieve symptoms like severe itching.
Oral steroids are usually the first-line treatment for poison ivy rash. This often includes medications such as:
- methylprednisolone (Medrol)
- prednisone (Rayos)
Betamethasone (Sernivo) is another topical steroid cream that can reduce itching. But it may cause skin damage if you use it for an extended period of time.
If your poison ivy rash is severe, a doctor may recommend a one-off steroid injection.
A poison ivy rash doesn’t involve the release of histamines. These are natural chemicals the body can produce during an allergic reaction. Because of this, antihistamines aren’t an effective treatment for a poison ivy skin rash. In some cases, antihistamines may even worsen a poison ivy rash.

Free prescription coupons
Seriously … free. Explore prices that beat the competition 70% of the time.
Get free cardWhat is mupirocin used for?
Mupirocin can be an effective treatment for bacterial infections like:
- staphylococcal (staph)
- streptococcal (strep)
- listeriosis
What rashes does mupirocin ointment treat?
Staph infections can lead to Ritter disease, a skin condition that causes a tender, itchy blister rash. A healthcare professional may prescribe mupirocin to treat Ritter disease, resulting from a staph infection.
Additionally, strep and staph infections can both cause impetigo. This skin condition causes itchy plaques. It typically affects children who live in hot and humid climates. Doctors may treat impetigo with mupirocin.
Download the free Optum Perks Discount Card to save up to 80% on some prescription medications.
Summary
Mupirocin is a topical antibiotic available as a cream or ointment that treats bacterial infections. Because mupirocin is an antibiotic, it isn’t a suitable treatment for poison ivy rash.
A poison ivy rash usually resolves on its own. However, steroid medications such as prednisone or triamcinolone may help ease itching.
If you have a rash caused by poison ivy and you want medication to help relieve itching, talk with your doctor or healthcare professional to find out what may work best for you.