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Medically Approved

Methocarbamol oral tablet vs. cyclobenzaprine oral tablet: A detailed guide

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OverviewUsesDosageSide effectsCostBrand namesFAQWarnings
Medically reviewed by Philip Ngo, PharmD
Updated on

Key takeaways

  • Methocarbamol and cyclobenzaprine are both prescribed for short-term musculoskeletal conditions, but cyclobenzaprine is specifically approved for muscle spasms, while methocarbamol helps ease muscle pain and stiffness.
  • You should not take these medications together due to the increased risk of side effects like drowsiness and dizziness, which can impair driving or operating machinery.
  • While both drugs can be effective for different indications, they have different dosages, potential side effects, and suitability for different age groups and health conditions, so a doctor should determine the best option based on individual needs.

Overview

This article explains how methocarbamol oral tablet and cyclobenzaprine oral tablet are similar and different. You can view detailed articles about methocarbamol oral tablet and cyclobenzaprine oral tablet if you’d like more information about these drugs.

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Uses of methocarbamol and cyclobenzaprine

Here’s a summary of the approved uses of methocarbamol oral tablet and cyclobenzaprine oral tablet:

 methocarbamol oral tabletcyclobenzaprine oral tablet
Approved usesto help relieve discomfort due to short-term painful musculoskeletal conditionsto help relieve muscle spasms due to short-term painful musculoskeletal conditions
Prescribed toadults and children ages 16 years and olderadults and children ages 15 years and older

These medications are prescribed alongside rest, physical therapy, and other nondrug measures for symptoms due to short-term, painful musculoskeletal conditions.

If you’d like to know more about taking either medication for your condition, ask your doctor. They can recommend whether methocarbamol oral tablet or cyclobenzaprine oral tablet is an option to consider.

Dosage of methocarbamol and cyclobenzaprine

The following are dosages provided by the drugmakers of methocarbamol oral tablet and cyclobenzaprine oral tablet. If your doctor prescribes either medication, you should follow the dosage they prescribe. They’ll advise the dosage that’s best for your condition. Do not adjust your dosage without first talking with your doctor.

Methocarbamol oral tablet’s dosage

Here is a summary of methocarbamol oral tablet’s recommended dosage in adults and certain children. Strength is expressed in milligrams (mg). The dosage varies depending on whether you’re prescribed the 500-mg or 750-mg oral tablet.

PurposeHow it’s takenUsual recommended dosage
to help relieve discomfort due to short-term, painful musculoskeletal conditions in adults and children ages 16 and olderby mouth1,500 mg taken four times per day for the first 2 to 3 days, followed by:
• 1,000 mg taken four times per day or,
• 750 to 1,500 mg taken three times per day

Cyclobenzaprine oral tablet’s dosage

Here is a summary of cyclobenzaprine oral tablet’s recommended dosage in adults and certain children. Strength is measured in milligrams (mg).

PurposeHow it’s takenUsual recommended dosage
to help relieve muscle spasms due to short-term, painful musculoskeletal conditions in adults and children ages 15 years and olderby mouth5 to 10 mg three times per day

Side effects of methocarbamol and cyclobenzaprine

Methocarbamol oral tablet and cyclobenzaprine oral tablet may cause mild or serious side effects. Some of the more common mild side effects of each drug are listed as follows. Serious side effects of methocarbamol oral tablet and cyclobenzaprine oral tablet are also listed.

Keep in mind that your side effects may differ from those listed here. They can vary based on your overall health, any other medications you take, and your age.

This article doesn’t include all possible side effects of these medications. To find more information, you can view the prescribing information for methocarbamol oral tablet and cyclobenzaprine oral tablet. You can also check out these articles about methocarbamol oral tablet side effects and cyclobenzaprine oral tablet side effects.

Mild side effects

Here are some of the mild side effects reported with methocarbamol oral tablet and cyclobenzaprine oral tablet:

 methocarbamol oral tablet*cyclobenzaprine oral tablet
drowsiness ✓
dry mouth
fatigue
headache✓ 
dizziness✓ 
changes in taste
mild allergic reaction

* These side effects are possible with methocarbamol oral tablet. But it’s unclear whether they occurred in the drug’s studies or after the drug became available for use.

Serious side effects

Here are serious side effects reported with methocarbamol oral tablet and cyclobenzaprine oral tablet:

 methocarbamol oral tablet*cyclobenzaprine oral tablet
serotonin syndrome (high levels of serotonin in your body) 
seizures
fast heart rate
slow heart rate
low blood pressure and fainting
heart rhythm problems
depression and anxiety
hallucinations
double vision
central nervous system (CNS) depression
low white blood cell level
liver problems, including yellowing of the skin and whites of the eyes
serious allergic reaction

* These side effects are possible with methocarbamol oral tablet. But it’s unclear whether they occurred in the drug’s studies or after the drug became available for use.

With a lot of drugs, serious side effects are possible, but they’re not common. If you have serious side effects from methocarbamol oral tablet or cyclobenzaprine oral tablet, call your doctor right away. If your symptoms are severe or you’re having a medical emergency, call 911 or a local emergency number.

Cost of methocarbamol and cyclobenzaprine

As with the cost of other medications, the cost of methocarbamol oral tablet and cyclobenzaprine oral tablet can vary. Their price may be affected by:

  • whether they’re covered by health insurance, if you have coverage
  • the pharmacy they’re purchased from

Coupons and cost savings

To view drug prices when Optum Perks coupons are applied, see this coupon page for methocarbamol oral tablet and this coupon page for cyclobenzaprine oral tablet. You can also check with your doctor, pharmacist, or insurance provider.

The options described in this article may also help you save on your prescription.

Note: Optum Perks coupons cannot be used with insurance copays or benefits.

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Brand-name versions

Methocarbamol oral tablet and cyclobenzaprine oral tablet are generic medications. The brand-name version of methocarbamol is Robaxin. The brand-name version of cyclobenzaprine is Amrix.

A generic medication is an identical copy of the active ingredient in a brand-name medication. (An active ingredient is what makes a medication work.) Generics usually cost less than brand-name drugs. And they’re thought to be as safe and effective as the brand-name versions.

If your doctor prescribed methocarbamol oral tablet or cyclobenzaprine oral tablet, but you’d like to know about taking its brand-name version, let your doctor or pharmacist know. They can help determine whether the brand-name version is right for you.

Questions about methocarbamol and cyclobenzaprine

Find answers to some common questions about methocarbamol oral tablet and cyclobenzaprine oral tablet as follows.

Is methocarbamol stronger than cyclobenzaprine?

Not necessarily. Like all drugs, you may respond differently to one medication than another. This may depend on:

  • the condition you’re taking the drug to treat and the severity of your symptoms
  • the dosage you’re prescribed
  • other medical conditions you have
  • other medications you take
  • your age

Methocarbamol and cyclobenzaprine are both approved to treat symptoms related to short-term, painful musculoskeletal conditions. But cyclobenzaprine is approved specifically to help relieve muscle spasms. And methocarbamol is approved to help ease muscle pain and stiffness. Depending on your symptoms, one drug may work better than the other.

If you have questions about whether methocarbamol or cyclobenzaprine is a better choice for you, talk with your doctor or pharmacist.

Can I take methocarbamol and cyclobenzaprine together?

No, it usually isn’t recommended to take methocarbamol and cyclobenzaprine together. This is because taking the drugs together could worsen side effects, such as drowsiness and dizziness. And either drug can affect your ability to drive or operate machinery.

If you find that either of these drugs isn’t managing your symptoms, talk with your doctor. They can review your treatment plan or suggest other options that are a better choice for treating your condition.

Between methocarbamol and cyclobenzaprine, which one is a better treatment for muscle pain or spasms?

Doctors may prescribe either methocarbamol oral tablet or cyclobenzaprine oral tablet to treat symptoms due to short-term painful musculoskeletal conditions. In studies, methocarbamol oral tablet and cyclobenzaprine oral tablet were both effective for this purpose.

That said, these medications differ in some ways. Cyclobenzaprine is approved specifically to help relieve muscle spasms. Methocarbamol is not. It does not directly relax tense muscles. There are also some other differences. For instance, they:

  • have some similar and different side effects
  • have different dosages
  • may be used in different age groups
  • may have different drug interactions

Keep in mind that your results from taking methocarbamol oral tablet or cyclobenzaprine oral tablet may differ from those seen in studies.

How do methocarbamol and cyclobenzaprine compare with tizanidine?

Tizanidine (Zanaflex) is another form of skeletal muscle relaxant. It’s most often used to treat muscle spasticity caused by conditions like multiple sclerosis. In this way, it’s more similar to cyclobenzaprine than methocarbamol. However, it may have a slightly different indication and cause different side effects.

Your doctor can help determine whether one option is better for your condition. They’ll recommend this based on your specific needs and health factors. Talk with your doctor if you’d like to learn more about which drug is right for you.

Warnings for methocarbamol oral tablet and cyclobenzaprine oral tablet

Some medications may not be recommended for you if you have certain factors affecting your health. These are referred to as a drug’s warnings.

Some people should not take methocarbamol oral tablet or cyclobenzaprine oral tablet, and others should take either medication with caution.

Before taking either medication, talk with your doctor about your health conditions, past surgeries, and any medications you take. Your doctor can recommend whether either drug is safe for you.

Warnings for methocarbamol oral tablet and cyclobenzaprine oral tablet are summarized in the following table:

 methocarbamol oral tabletcyclobenzaprine oral tablet
heart rhythm problems, heart failure, or a recent heart attack ✓ 
thyroid problems✓ 
serotonin syndrome
urinary retention
angle-closure glaucoma or increased pressure in the eye
liver problems
use of alcohol or other CNS depressants during treatment
current use of a monoamine oxidase inhibitor or use within the past 14 days ✓ 
use of anticholinergic drugs✓ ✓ 
allergic reaction to either drug or any of their ingredients✓ ✓ 
being age 65 years or older✓ ✓ 
currently pregnant or planning to become pregnant✓  
currently breastfeeding or planning to breastfeed

You can view more detailed articles about methocarbamol oral tablet and cyclobenzaprine oral tablet if you’d like to know more about warnings for these drugs. You can also view the prescribing information for methocarbamol oral tablet and cyclobenzaprine oral tablet.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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