Farxiga interactions

This article describes possible interactions with Farxiga oral tablet. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.

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Other drugs and Farxiga

The drugs in the list below may interact with Farxiga. This article doesn’t include all drugs that may interact with Farxiga.

Drug classes or drugs that may interact with Farxiga include:

• atypical antipsychotics
  • drug examples: aripiprazole (Abilify, others), olanzapine (Zyprexa)
  • what might happen: atypical antipsychotics can increase blood sugar levels and make Farxiga less effective
• corticosteroids
  • drug examples: prednisone (Rayos), dexamethasone (Hemady)
  • what might happen: corticosteroids can increase blood sugar levels and make Farxiga less effective
• fibric acid derivatives
  • drug examples: fenofibrate (Antara, others), gemfibrozil (Lopid)
  • what might happen: can increase the risk of low blood sugar (hypoglycemia) and may require a Farxiga dose reduction
• insulin drugs
  • drug examples: insulin glargine (Lantus, others), insulin aspart (Novolog, others)
  • what might happen: can increase the risk of low blood sugar as a side effect of Farxiga or the insulin drug
• sulfonylureas
  • drug examples: glipizide (Glucotrol XL), glimepiride (Amaryl)
  • what might happen: can increase the risk of low blood sugar as a side effect of Farxiga or the sulfonylurea drug
• certain medications for treating hepatitis C
  • drug examples: Harvoni (ledipasvir/sofosbuvir), Mavyret (glecaprevir/pibrentasvir)
  • what might happen: can make Farxiga more effective, which can increase the risk of low blood sugar (hypoglycemia)
• lithium (Lithobid)
  • what might happen: can make lithium less effective
• ritonavir (Norvir) and treatments that contain it
  • drug examples: Kaletra (lopinavir/ritonavir), Paxlovid (nirmatrelvir/ritonavir)
  • what might happen: can increase blood sugar levels and make Farxiga less effective

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Questions about Farxiga and interactions

Here you’ll find answers to some common questions about Farxiga and possible interactions.

Is it safe to take Farxiga and metformin together?

Yes, it’s safe to take Farxiga and metformin together. These medications aren’t known to interact.

Doctors may use both metformin and Farxiga to help manage blood sugar levels in people with type 2 diabetes. In fact, the drug Xigduo XR contains both dapagliflozin (the active ingredient in Farxiga, which is what makes a drug work) and metformin in one tablet.

Talk with your doctor or pharmacist if you’d like to learn more about how metformin and Farxiga compare, or if you’d benefit from taking both medications rather than just one.

Why can’t you have caffeine with Farxiga?

Farxiga isn’t known to interact with caffeine. There aren’t reports of caffeine being unsafe to consume while taking Farxiga.

There are studies showing that moderate caffeine intake (including from coffee) does not necessarily make you dehydrated. Dehydration can increase the risk of side effects of Farxiga, and Farxiga itself can cause dehydration. So, while it’s important to keep hydration in mind while taking Farxiga, you shouldn’t need to avoid consuming coffee or caffeine entirely.

However, caffeine can interact with certain other medications and health conditions. Talk with your doctor or pharmacist if you’d like to know more about whether it’s safe for you to consume caffeine.

When to avoid Farxiga

Certain health conditions or other factors could increase some risks with Farxiga. Because of this, doctors may not prescribe Farxiga in these cases. These health conditions or other factors are called contraindications.

Here’s a list of contraindications for Farxiga:

• Past allergic reaction to Farxiga: If you’ve ever had an allergic reaction to Farxiga, taking it again may cause another allergic reaction.

Before you start taking Farxiga, talk with your doctor about the contraindications of Farxiga. They can recommend whether you should take Farxiga.

Alcohol and Farxiga

Farxiga is known to interact with alcohol. If you drink alcohol, you should avoid consuming large amounts while taking Farxiga.

Taking Farxiga and drinking alcohol, especially in large amounts, can raise your risk of ketoacidosis. This is a rare but serious side effect of Farxiga.

If you drink alcohol, talk with your doctor about whether it’s safe to consume it while taking Farxiga.

Other interactions and Farxiga

Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether Farxiga has these interactions. 

The information below doesn’t include all other possible interactions with Farxiga.

Farxiga and supplements

Before taking Farxiga oral tablet, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Farxiga and herbs

Farxiga oral tablet may interact with garlic supplements. This herb is often used for managing blood sugar. Because Farxiga works to lower blood sugar, taking a garlic supplement at the same time can cause your blood sugar to become too low.

Because of this, ask your doctor or pharmacist before taking any of these products while taking Farxiga.

Farxiga and vitamins and minerals

Farxiga oral tablet may interact with chromium supplements. This mineral is often used for managing blood sugar. Since Farxiga lowers blood sugar, taking this combination could cause your blood sugar to become too low.

Because of this, ask your doctor or pharmacist before taking any of these products while taking Farxiga oral tablet.

Farxiga and food

Farxiga oral tablet isn’t known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist about what foods you should avoid while taking Farxiga oral tablet.

Note: While Farxiga may interact with garlic supplements, it isn’t expected to interact with garlic used in cooking or found in food.

Farxiga and vaccines

Farxiga oral tablet isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.

Because of this, talk with your doctor or pharmacist before receiving any vaccines while taking Farxiga oral tablet.

Farxiga and lab tests

Farxiga oral tablet can interact with the following lab tests:

• urine glucose: this test measures the amount of glucose (sugar) in the urine
• 1,5-anhydroglucitol: this test estimates your average blood sugar level after meals over the previous 1 to 2 weeks

These tests are used to monitor how well your blood sugar levels are managed. Your doctor will likely order different tests to see how well your diabetes is managed instead.

Farxiga and cannabis or CBD

Farxiga oral tablet isn’t known to interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But this doesn’t mean interactions can’t happen or won’t be identified later.

As with any drug or supplement, tell your doctor before taking cannabis with Farxiga.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Health factors and Farxiga

Certain medical conditions or other health factors may increase the risk of interactions with Farxiga oral tablet. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking Farxiga, tell your doctor about your health history. They’ll determine whether Farxiga is right for you.

These health conditions or other factors might interact with Farxiga oral tablet:

• current or frequent history of genital yeast infection or urinary tract infection (UTI)
• liver condition, such as cirrhosis
• current or past pancreatitis
• frequent dehydration, or are at risk of becoming dehydrated (such as working outside in a hot climate)
• low sodium (salt) diet
• type 1 diabetes (Farxiga should not be taken for treating type 1 diabetes)
• pregnancy or breastfeeding
• past allergic reaction to Farxiga

Preventing Farxiga interactions

You may be able to help avoid certain interactions with Farxiga oral tablet. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.

Things to consider include:

• Whether you drink alcohol or use cannabis.
• Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
• What to do if you’re prescribed a new drug while taking Farxiga oral tablet.

Taking Farxiga exactly as prescribed can also help prevent interactions.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.