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Medically Approved

Dofetilide oral capsule dosage: A detailed guide

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Form and strengthsDosageFAQHow it's takenCouponOverdoseAsk your doctorBoxed warning
Doctors prescribe dofetilide oral capsule to treat certain heart rhythm problems in adults. You’ll start dofetilide in a healthcare facility or hospital. You take it by mouth two times per day.
Medically reviewed by Beth Johnston, PharmD, BCPS
Updated on

This article describes dofetilide oral capsule’s dosages and strengths and gives details on its administration. You’ll also find information on cost savings and coupon options for dofetilide. To learn more about dofetilide oral capsule, talk with your doctor.

Dofetilide oral capsule is a generic version of the brand-name drug Tikosyn. This article describes dosages of dofetilide.

Boxed warning: Risk of arrhythmia

Dofetilide has a boxed warning for the risk of arrhythmia (irregular heart rhythm). A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

See the end of this article for more information about this warning.

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Form and strengths of dofetilide

Dofetilide oral capsule comes as follows:

  • Form: oral capsule, which you swallow
  • Strengths: 125 micrograms (mcg), 250 mcg, 500 mcg

Dosage of dofetilide

This article describes the recommended dosages for dofetilide oral capsule. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of dofetilide oral capsule without your doctor’s recommendation.

Usual recommended dosage of dofetilide in adults

At first, you’ll be admitted to a healthcare facility or hospital and receive an individualized dosage of dofetilide. Here, you’ll receive electrocardiographic (ECG) monitoring for at least 3 days.

Your doctor may prescribe dofetilide oral capsule to take after you are discharged from the hospital. Your doctor will prescribe the smallest dosage of dofetilide oral capsule that gives the desired outcome.

PurposeUsual doseMaximum doseFrequency
to convert abnormal heart rhythms (atrial fibrillation and atrial flutter) to a normal sinus rhythmindividualized500 mcgtwo times per day
to maintain a normal sinus rhythm after it has been converted from an abnormal heart rhythm (atrial fibrillation or atrial flutter)individualized500 mcgtwo times per day

Dosage adjustments for dofetilide

Your doctor will prescribe a dosage of dofetilide oral capsule based on several factors. These include:

  • the specific condition being treated and how severe it is
  • other health conditions you may have
  • how well your kidneys work
  • based on certain ECG monitoring results

Your doctor will test your kidney function before your start dofetilide. If your kidney’s aren’t working as well as they should, they will likely lower your dosage of dofetilide.

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Missed dose of dofetilide

You will receive your first doses of dofetilide in the hospital or a healthcare facility. Then, you’ll likely continue treatment at home.

If you miss a dose of dofetilide, take your next dose as you usually would. Do not take two doses at the same time. If you have other questions about missed doses, talk with your doctor or pharmacist.

For tips on how to plan your doses of dofetilide oral capsule , read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about dofetilide oral capsule and its dosage.

Does dofetilide have a recommended loading dose?

No. There isn’t a recommended loading dose (a dose you receive at the beginning of treatment that’s higher than your normal dose) of dofetilide.

The dosage of dofetilide is individualized. Your doctor will prescribe a dosage that’s right for you.

If you have questions about your dosage of dofetilide, talk with your doctor.

Is dofetilide taken long term?

Yes, doctors typically prescribe dofetilide oral capsule as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term. You’ll also have ongoing ECG monitoring and blood tests usually every 3 months or as needed.

If you have questions about how long you should take dofetilide oral capsule, talk with your doctor.

How dofetilide is taken

You’ll swallow dofetilide oral capsule twice per day. You will receive your first doses of dofetilide in the hospital or a healthcare facility. Here, you’ll receive electrocardiographic (ECG) monitoring for at least 3 days.

Once you’re discharged from the hospital, you’ll likely continue taking dofetilide oral capsule at home two times per day. You can take dofetilide oral capsule with or without food.

Your doctor may advise that you take this medication around the same time each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

Dofetilide oral capsule shouldn’t be stopped suddenly. Talk to your doctor if you have concerns about taking dofetilide.

You should swallow capsules whole. If it’s hard for you to swallow capsules, see this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

Dofetilide coupon

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Overdose of dofetilide

It’s important that you do not take more dofetilide oral capsule than your doctor prescribes. Doing so can lead to harmful effects.

What to do if you take too much dofetilide

If you think you’ve taken too much dofetilide, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosage for dofetilide oral capsule. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of dofetilide oral capsule without your doctor’s recommendation. You should take dofetilide oral capsule exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • What medical test results do doctors use to calculate my dosage of dofetilide oral capsule?
  • How does the dosage of dofetilide oral capsule compare with the dosage of Tikosyn?
  • If I have kidney problems, how will my dosage of dofetilide oral capsule be calculated?

Boxed warning for dofetilide

Dofetilide has a boxed warning for the risk of arrhythmia. A boxed warning is the most serious warning from the FDA.

Dofetilide can increase the risk of arrhythmia. In some cases, these arrhythmias can be life threatening. Due to this risk, you will start your treatment in a healthcare facility. Here, you’ll receive continuous ECG monitoring for at least 3 days.

To learn more about this risk, you can also talk with your doctor.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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