This article describes possible interactions with dexlansoprazole delayed-release oral capsule. (Delayed-release drugs are released into your body more slowly.) Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.
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Other drugs and dexlansoprazole
The drugs in the list below may interact with dexlansoprazole delayed-release oral capsule. This article doesn’t include all drugs that may interact with dexlansoprazole.
Drug classes or drugs that may interact with dexlansoprazole delayed-release oral capsule include:
- certain antifungal drugs
- drug examples: ketoconazole, itraconazole (Tolsura, Sporanox)
- what might happen: can make the antifungal drug less effective
- certain antiretroviral drugs
- drug examples: atazanavir (Reyataz), rilpivirine (Edurant)*
- what might happen: it varies, depending on the specific antiretroviral; some antiretrovirals may be less effective, others may have an increased risk of side effects
- certain tyrosine kinase inhibitors
- cefuroxime
- what might happen: can make cefuroxime less effective
- digoxin (Lanoxin)
- what might happen: can increase the effect and risk of side effects of digoxin
- methotrexate (Trexall, others)
- what might happen: can increase the risk of side effects of digoxin
- mycophenolate mofetil (CellCept)
- what might happen: can make mycophenolate mofetil less effective
- tacrolimus (Prograf, others)
- what might happen: can increase the effect and risk of side effects of tacrolimus
- warfarin (Jantoven)
- what might happen: can increase the risk of side effects of warfarin
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*To learn more, see the “When to avoid” section below.
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Get free cardWhen to avoid dexlansoprazole
Certain health conditions or other factors could increase some risks with dexlansoprazole delayed-release oral capsule. Because of this, doctors may not prescribe dexlansoprazole in these cases. These health conditions or other factors are called contraindications.
Here’s a list of contraindications for dexlansoprazole delayed-release oral capsule:
- Taking rilpivirine or treatments that contain it: If you take rilpivirine or treatments that contain it, taking dexlansoprazole delayed-release oral capsule may reduce the effect of rilpivirine. It can also cause HIV resistance to rilpivirine. Due to this serious risk, doctors would not usually prescribe dexlansoprazole and rilpivirine together. They also won’t prescribe dexlansoprazole with treatments that contain rilpivirine, such as Cabenuva (cabotegravir/rilpivirine).
- Past allergic reaction to dexlansoprazole: If you’ve ever had an allergic reaction to dexlansoprazole delayed-release oral capsule, taking it again may cause another allergic reaction.
Before you start taking dexlansoprazole, tell your doctor if anything listed above relates to you. They can recommend whether you should take dexlansoprazole.
Alcohol and dexlansoprazole
Dexlansoprazole delayed-release oral capsule is not known to have interactions with alcohol.
If you drink alcohol, talk with your doctor about whether it’s safe to consume it while taking dexlansoprazole delayed-release oral capsule.
Other interactions and dexlansoprazole
Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether dexlansoprazole delayed-release oral capsule has these interactions.
The information below doesn’t include all other possible interactions with dexlansoprazole.
Dexlansoprazole and supplements
Before taking dexlansoprazole delayed-release oral capsule, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Dexlansoprazole interactions with herbs
Dexlansoprazole delayed-release oral capsule may interact with St. John’s wort. This herb is often used to ease the symptoms of depression.
Taking dexlansoprazole and St. John’s wort may make dexlansoprazole less effective.
Because of this, ask your doctor or pharmacist before taking this or other herbs while taking dexlansoprazole delayed-release oral capsule.
Dexlansoprazole interactions with vitamins and minerals
Dexlansoprazole delayed-release oral capsule may interact with iron, a mineral found in iron supplements and some multivitamin products. Iron supplements are used to prevent and treat anemia due to an iron deficiency.
Taking dexlansoprazole and iron may make iron supplements less effective.
Because of this, ask your doctor or pharmacist before taking iron supplements while taking dexlansoprazole delayed-release oral capsule.
Dexlansoprazole and food
Dexlansoprazole delayed-release oral capsule isn’t known to interact with foods. You may take dexlansoprazole before or after a meal.
But this doesn’t mean interactions with foods can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist about possible foods you should avoid while taking dexlansoprazole delayed-release oral capsule.
Dexlansoprazole and vaccines
Dexlansoprazole delayed-release oral capsule isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before receiving any vaccines while taking dexlansoprazole delayed-release oral capsule.
Dexlansoprazole and lab tests
Dexlansoprazole delayed-release oral capsule may interact with certain lab tests. These tests include:
- Urine tests to check tetrahydrocannabinol (THC). Dexlansoprazole can cause a false-positive result on this test. A “false positive” means the test result shows THC in your urine, even if it actually isn’t.
- The secretin stimulation test is used to measure the response of your pancreas to secretin (a hormone made by the small intestine). Dexlansoprazole can cause a false-positive result on this test.
- A blood test to check your chromogranin A level. This test is used to check neuroendocrine tumors. Dexlansoprazole can cause a false-positive result on this test.
Because of this, talk with your doctor or pharmacist before having any lab tests performed while taking dexlansoprazole delayed-release oral capsule.
Dexlansoprazole and cannabis or CBD
Dexlansoprazole delayed-release oral capsule isn’t known to interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But this doesn’t mean interactions can’t happen or won’t be identified later.
As with any drug or supplement, tell your doctor before taking cannabis with dexlansoprazole.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Health factors and dexlansoprazole
Certain medical conditions or other health factors may increase the risk of interactions with dexlansoprazole delayed-release oral capsule. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking dexlansoprazole, tell your doctor about your health history. They’ll determine whether dexlansoprazole is right for you.
These health conditions or other factors might interact with dexlansoprazole delayed-release oral capsule:
- kidney conditions, such as chronic kidney disease
- liver conditions, such as cirrhosis
- low level of calcium, magnesium, potassium, or sodium in your blood
- vitamin B12 deficiency
- systemic lupus erythematosus or cutaneous lupus
- osteoporosis
- pregnancy or breastfeeding
- past allergic reaction to dexlansoprazole
Preventing dexlansoprazole interactions
You may be able to help avoid certain interactions with dexlansoprazole delayed-release oral capsule. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.
Things to consider include:
- Whether you drink alcohol or use cannabis.
- Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
- What to do if you’re prescribed a new drug while taking dexlansoprazole delayed-release oral capsule.
Taking dexlansoprazole exactly as prescribed can also help prevent interactions.
What to ask your doctor
If you have questions about dexlansoprazole and possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Can I take dexlansoprazole (Dexilant) and omeprazole together?
- Do I need to take my medications at different times throughout the day to avoid interactions?
- If I take dexlansoprazole and have certain health conditions such as lupus, will I be monitored more closely during treatment?
- Does my risk of interactions depend on how long I need to take dexlansoprazole?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.