Medically Approved

Are Prozac and Adderall safe to take together?

Prozac and Adderal

Optum Perks Author

By Optum Perks Author

Before taking multiple medications, it’s important to understand any potential drug interactions. 

Adderall is a prescription stimulant that contains 2 drugs: amphetamine and dextroamphetamine. Doctors typically use it to treat attention deficit hyperactivity disorder (ADHD).

Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant that works by increasing the activity of serotonin in your brain. It’s prescribed by doctors to treat conditions like: 

  • Depression
  • Panic disorder
  • Bulimia
  • Premenstrual dysphoric disorder (PMDD)

Prozac may increase the effects of both primary components of Adderall (amphetamine and dextroamphetamine). This could lead to side effects, such as:

  • Anxiety
  • Racing thoughts
  • Nervousness
  • Restlessness
  • Nausea 
  • Confusion

Combining Adderall and Prozac can also increase the risk of serotonin syndrome. Serotonin syndrome is a serious side effect that has major health risks. Don’t take Adderall and Prozac together unless you’re being closely monitored by your doctor.

What is serotonin syndrome? 

Serotonin syndrome happens when you have too much serotonin in your body. It can cause symptoms like:

  • Increased heart rate
  • Blurry vision
  • Dizziness
  • Hallucination
  • Agitation
  • Muscle twitching or tremors
  • Nausea and vomiting

In rare cases, serotonin syndrome can result in coma and death.


If you begin experiencing any of these symptoms while taking Adderall and Prozac, talk with your doctor. Don’t take Adderall and Prozac together unless your doctor is closely monitoring you.

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How is serotonin syndrome treated? 

If you experience serotonin syndrome, your doctor will evaluate your symptoms. They may recommend:

  • Benzodiazepines, or muscle relaxants, such as lorazepam (Ativan) or diazepam (Valium)
  • Serotonin-production blocking agents, such as cyproheptadine
  • Heart rate and blood pressure medications: such as nitroprusside (Nitropress) or phenylephrine (Vazculep)

In certain circumstances, your doctor may order oxygen, intravenous fluids (IV), or a breathing tube and machine.


Unless closely monitored by a doctor, you shouldn’t take Adderall and Prozac together.


When taken in combination, Prozac and Adderall could result in serotonin syndrome, a potentially serious condition.