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Medically Approved

Aplenzin dosage: A detailed guide

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Form and strengthsDosageFAQHow it’s takenCouponOverdoseAsk your doctorBoxed warning
Doctors prescribe Aplenzin for certain types of depression, including major depressive disorder (MDD) and seasonal affective disorder (SAD). You take it by mouth once per day.
Medically reviewed by Rosanna Sutherby, PharmD
Updated on

This article describes Aplenzin’s dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for Aplenzin. If you want to know more about Aplenzin, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.

Aplenzin is a brand-name medication that comes as an extended-release oral tablet. (Extended release means the drug is slowly released into your body over a long period of time.) Aplenzin isn’t available in a generic version. This article describes dosages of Aplenzin.

Boxed warning: Risk of suicidal thoughts and behaviors

Aplenzin has a boxed warning for the risk of suicidal thoughts and behaviors. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

See the end of this article for more information about this warning.

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Form and strengths of Aplenzin

Aplenzin comes as follows:

  • Form: tablet that you swallow
  • Strengths: 174 milligrams (mg), 348 mg, 522 mg

Dosage of Aplenzin

This article describes the recommended dosages for Aplenzin. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of Aplenzin without your doctor’s recommendation.

Usual recommended dosages of Aplenzin in adults

Usually, doctors start by prescribing a low dosage of Aplenzin. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of Aplenzin that gives the desired outcome.

Dosage for certain types of depression

Below is the recommended dosages of Aplenzin. The dosages are in milligrams (mg).

ConditionStarting dosageTarget dosage
MDD174 mg once per day in the morning348 mg once per day in the morning
SAD174 mg once per day348 mg once per day in the morning

Dosage adjustments for Aplenzin

Your doctor will prescribe a dosage of Aplenzin based on several factors. These include:

  • the specific condition being treated and how severe it is
  • your age
  • other health conditions you may have
  • other medications you may take

Missed dose of Aplenzin

Talk with your doctor or pharmacist right away if you realize you forgot to take a dose of Aplenzin. They may advise you to skip it and take your next dose as scheduled.

For tips on how to plan your doses of Aplenzin and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about Aplenzin and its dosage.

How does the dosage of Aplenzin compare with the dosage of Wellbutrin?

Similar to Aplenzin, Wellbutrin comes as an extended-release oral tablet called Wellbutrin XL. Aplenzin and Wellbutrin both contain the same active ingredient, bupropion. They both are used to treat MDD and SAD. (An active ingredient is what makes a drug work.) Wellbutrin also comes as a sustained-release oral tablet called Wellbutrin SR. (With sustained release, the drug is released over a certain period of time.) Wellbutrin SR is only used to treat MDD.

The following table shows the recommended dosages of Aplenzin, Wellbutrin XL, and Wellbutrin SR:

ConditionAplenzinWellbutrin XLWellbutrin XR
MDD348 mg once per day300 mg once per day150 mg twice per day
SAD348 mg once per day300 mg once per daynot approved for use

If you have questions about how the dosages of these drugs compare, talk with your doctor.

Can Aplenzin be used for anxiety, weight loss, or ADHD? If so, what is the dosage?

Aplenzin isn’t approved for anxiety, weight loss, or attention deficit hyperactivity disorder (ADHD). It’s approved to treat MDD and SAD. However, in some cases, doctors may prescribe Aplenzin off-label for anxiety, weight loss, or ADHD. With off-label use, doctors prescribe a drug for a purpose other than what it’s approved for.

If you have questions about treatment options for anxiety, weight loss, or ADHD, talk with your doctor.

Is Aplenzin taken long term?

Yes, doctors typically prescribe Aplenzin as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

If you have questions about how long you should take Aplenzin, talk with your doctor.

How Aplenzin is taken

You’ll swallow Aplenzin once per day in the morning. You can take it with or without food.

Your doctor may advise that you take this medication around the same time each day. This helps keep a consistent amount of the drug in your body. And that can help the drug work more effectively.

You should not crush, divide, or chew Aplenzin tablets. Doing so can increase your risk of serious side effects, including seizures. Swallow the tablets whole. If it’s hard for you to swallow tablets, view this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

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Overdose of Aplenzin

It’s important that you do not take more Aplenzin than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of Aplenzin overdose

Symptoms of an overdose can include:

What to do if you take too much Aplenzin

If you think you’ve taken too much Aplenzin, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for Aplenzin. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of Aplenzin without your doctor’s recommendation. You should take Aplenzin exactly as your doctor prescribes it. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • Will you change my dosage of Aplenzin if I take other drugs with it?
  • Will a higher dosage of Aplenzin increase my risk of side effects?
  • How does the dosage of Aplenzin compare with other drugs used for my condition?

Boxed warning for Aplenzin

Aplenzin has a boxed warning for the risk of suicidal thoughts and behaviors. A boxed warning is the most serious warning from the FDA.

Antidepressants, such as Aplenzin, can cause suicidal thoughts and behaviors. This risk is especially high for people under the age of 24 years.

Due to this risk, your doctor will monitor you for suicidal thoughts or behaviors, worsening depression, and unusual changes in behavior. If you or someone close to you recognizes any signs of suicidal thoughts, talk with your doctor right away.

If you have thoughts of suicide during Aplenzin treatment, call the Suicide and Crisis Lifeline by dialing 988. Or tell your doctor right away. You can also refer to this article for ways to seek support.

Talk with your doctor to learn more.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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