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Amphetamine/dextroamphetamine dosage: A detailed guide

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Forms and strengthsDosageFAQHow it’s takenCouponOverdoseAsk your doctorBoxed warning
Doctors prescribe amphetamine/dextroamphetamine oral forms for attention deficit hyperactivity disorder (ADHD) or narcolepsy. You take it by mouth once or twice per day depending on the form you’re prescribed.
Medically reviewed by Beth Johnston, PharmD, BCPS
Updated on

This article describes amphetamine/dextroamphetamine dosages and strengths and gives details on how to take it. You’ll also find information on cost savings and coupon options for amphetamine/dextroamphetamine. If you want to know more about amphetamine/dextroamphetamine, see this overview article. It covers details about the drug’s uses and side effects, ways to save on cost, and more.

Amphetamine/dextroamphetamine oral forms are the generic version of the brand-name drug Adderall IR oral tablet and Adderall XR oral capsule. IR means “immediate release”, which means the drug is released into your body right away. XR means “extended release”, which means the drug is slowly released into your body over a long period of time.

Boxed warning: Risk of misuse and addiction

Amphetamine/dextroamphetamine has a boxed warning for the risk of misuse and dependence. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

See the “Boxed Warning” section below for more information about this warning.

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Forms and strengths of amphetamine/dextroamphetamine

Amphetamine/dextroamphetamine comes in these forms and strengths, strengths are expressed in milligrams (mg): 

FormHow to takeStrengths


Amphetamine/dextroamphetamine IR oral tablet
take by swallowing• 5 mg
• 7.5 mg
• 10 mg
• 12.5 mg
• 15 mg
• 20 mg
• 30 mg

Amphetamine/dextroamphetamine XR capsule
take by swallowing• 5 mg
• 10 mg
• 15 mg
• 20 mg
• 25 mg
• 30 mg

Dosage of amphetamine/dextroamphetamine

This article describes the recommended dosages for amphetamine/dextroamphetamine oral forms. The drugmaker provides these dosages.

If your doctor prescribes this medication, you should follow the dosage they prescribe. Your doctor will determine the dosage that best meets your needs. Do not change your dosage of amphetamine/dextroamphetamine oral forms without your doctor’s recommendation.

Usual recommended dosages of amphetamine/dextroamphetamine IR oral tablet in adults

Usually, doctors start by prescribing a low dosage of amphetamine/dextroamphetamine IR oral tablet. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of amphetamine/dextroamphetamine IR oral tablet that gives the desired outcome.

ConditionStarting dosage Maintenance dosage
attention deficit hyperactivity disorder (ADHD)5 mg once or twice per dayIncrease by 5 mg per week as needed. Some people may be prescribed three doses per day.
to help people with narcolepsy stay alert and awake during the day10 mg once per dayIncrease by 10 mg per week as needed. Some people may be prescribed three doses per day.

Usual recommended dosages of amphetamine/dextroamphetamine XR oral capsule in adults

Usually, doctors start by prescribing a low dosage of amphetamine/dextroamphetamine XR oral capsule. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of amphetamine/dextroamphetamine XR oral capsule that gives the desired outcome.

ConditionStarting dosageMaintenance dosage
ADHD 20 mg once per day individualized

Dosages of amphetamine/dextroamphetamine IR oral tablet in children

Usually, doctors start by prescribing a low dosage of amphetamine/dextroamphetamine IR oral tablet. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of amphetamine/dextroamphetamine IR oral tablet that gives the desired outcome.

Amphetamine/dextroamphetamine IR oral tablet is not recommended in children under ages 3 years to treat ADHD. Also, amphetamine/dextroamphetamine IR oral tablet isn’t recommended in children under ages 6 years to treat narcolepsy.

ConditionAgeStarting dosageMaintenance dosage
ADHD3–5 years2.5 mg once per dayincrease by 2.5 mg per week as needed. Some people may be prescribed three doses per day.
ADHD6 years and older5 mg once or twice per dayincrease by 5 mg per week as needed. Some people may be prescribed three doses per day.
to help people with narcolepsy stay alert and awake during the day6–12 years5 mg once per dayincrease by 5 mg per week as needed. Some people may be prescribed three doses per day.
to help people with narcolepsy stay alert and awake during the day12 years and older10 mg once per dayincrease by 10 mg per week as needed. Some people may be prescribed three doses per day.

Dosages of amphetamine/dextroamphetamine XR oral capsule in children

Usually, doctors start by prescribing a low dosage of amphetamine/dextroamphetamine XR oral capsule. Then, they’ll adjust it over time until the right dosage is reached. Ultimately, your doctor will prescribe the smallest dosage of amphetamine/dextroamphetamine XR oral capsule that gives the desired outcome.

The maximum dosage for children ages 6–12 years of age is 30 mg once per day. Amphetamine/dextroamphetamine XR oral capsule is not recommended in children under the ages 6 years.

ConditionAgeStarting dosageMaintenance dosage
ADHD6–12 years 5 or 10 mg once per dayincrease by 5 mg or 10 mg per week as needed
ADHD13–17 years 10 mg once per dayincrease to 20 mg per day after 1 week if needed

Dosage adjustments for amphetamine/dextroamphetamine

Your doctor will prescribe a dosage of amphetamine/dextroamphetamine oral forms based on several factors. These include:

  • the specific condition being treated and how severe it is
  • your age
  • other health conditions you may have
  • other medications you may take

Missed dose of amphetamine/dextroamphetamine

Talk with your doctor or pharmacist right away if you realize you have forgotten to take a dose of amphetamine/dextroamphetamine oral forms. They may advise you to take the missed dose, or they may advise you to skip it and take your next dose as scheduled.

For tips on how to plan your doses of amphetamine/dextroamphetamine oral forms and avoid missing a dose, read this article. You could also try:

  • downloading a reminder app on your phone
  • setting an alarm
  • putting a note where you’ll see it, such as on your calendar, bathroom mirror, or bedside table

Frequently asked questions

Below are answers to some commonly asked questions about amphetamine/dextroamphetamine oral forms and their dosage.

How does the dosage of amphetamine/dextroamphetamine compare with the dosage of Vyvanse?

Amphetamine/dextroamphetamine and Vyvanse are both approved to treat attention deficit hyperactivity disorder (ADHD). However, they contain different active ingredients. An active ingredient is what makes the drug work. For this reason, their dosages are different. The active ingredient in Vyvanse is lisdexamfetamine, while amphetamine/dextroamphetamine contains mixed amphetamine salts.

To learn more about how amphetamine/dextroamphetamine and Vyvanse compare, see this article. For information about the dosage of Vyvanse, see this article. Also, talk with your doctor, they can recommend the medication that’s right for your condition.

Is amphetamine/dextroamphetamine taken long term?

It’s possible. Doctors may prescribe amphetamine/dextroamphetamine oral forms as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you may take it long term.

If you have questions about how long you should take amphetamine/dextroamphetamine, talk with your doctor.

How amphetamine/dextroamphetamine is taken

You’ll swallow amphetamine/dextroamphetamine oral forms by mouth once, twice, or three times per day, depending on the form you’re prescribed. You’ll take your first dose when you wake up. If you take amphetamine/dextroamphetamine more than once per day, the other dose(s) should be 4–6 hours apart.

Your doctor may advise you to take this medication around the same time each day. This helps keep a consistent amount of the drug in your body, which makes the drug work more effectively.

Amphetamine/dextroamphetamine oral forms can be taken with or without food. Taking it with food may help prevent stomach upset.

Amphetamine/dextroamphetamine XR oral capsule should not be chewed, split, or crushed. Amphetamine/dextroamphetamine XR oral capsules may be opened, and the contents sprinkled on applesauce and taken right away. The sprinkled medication beads should not be chewed, broken, or crushed.

If it’s hard for you to swallow capsules or tablets, view this article. It provides suggestions on how to swallow medications that come in pill form.

Also, be sure to talk with your doctor or pharmacist if you’re having difficulty taking your medication. They can offer recommendations about taking it.

Amphetamine/dextroamphetamine coupon

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Overdose of amphetamine/dextroamphetamine

It’s important that you do not take more amphetamine/dextroamphetamineoral forms than your doctor prescribes. Doing so can lead to harmful effects.

Symptoms of amphetamine/dextroamphetamine overdose

Symptoms of an overdose can include:

What to do if you take too much amphetamine/dextroamphetamine

If you think you’ve taken too much amphetamine/dextroamphetamine, call your doctor or pharmacist right away. Or you could call 800-222-1222 to speak with someone at America’s Poison Centers. You can also use its online resource. If you have severe symptoms, call 911 or a local emergency number immediately. You can also go to the closest emergency room.

What to ask your doctor

This article describes the usual recommended dosages for amphetamine/dextroamphetamine oral forms. If your doctor prescribes this medication, they’ll determine the dosage that’s best for you.

Do not change your dosage of amphetamine/dextroamphetamine oral forms without your doctor’s recommendation. You should take amphetamine/dextroamphetamine oral forms exactly as your doctor prescribes them. Let your doctor know if you have concerns or questions about your treatment plan.

Here’s a list of some possible questions you may want to ask your doctor:

  • Why are the dosages for amphetamine/dextroamphetamine IR and amphetamine/dextroamphetamine XR different?
  • How do the dosages of amphetamine/dextroamphetamine and brand-name Adderall compare?
  • If I have kidney problems, will you be adjusting my dosage of amphetamine/dextroamphetamine?

Boxed warning for amphetamine/dextroamphetamine

Amphetamine/dextroamphetamine has a boxed warning for the risk of misuse and dependence. A boxed warning is the most serious warning from the FDA.

Amphetamine/dextroamphetamine is a controlled substance. Controlled substances are regulated by the government because they carry a risk of misuse or dependence. 

Misuse means that a drug is used in a way other than it was prescribed. With dependence, your body needs the drug to function like it normally would. Misuse of and dependence on amphetamine/dextroamphetamine oral forms can lead to overdose, which can be life threatening.

Before you begin taking amphetamine/dextroamphetamine oral forms, your doctor will assess your risk. They will also monitor you during your treatment for signs of misuse and addiction.

You can talk with your doctor to learn more about this warning.

Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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