This article describes possible interactions with chlorthalidone oral tablet. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.
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Other drugs and chlorthalidone
The drugs in the list below may interact with chlorthalidone oral tablet. This article doesn’t include all drugs that may interact with chlorthalidone.
Drug classes or drugs that may interact with chlorthalidone oral tablet include:
- angiotensin converting enzyme (ACE) inhibitors:
- angiotensin II receptor blockers (ARBs):
- drug examples: valsartan (Diovan), olmesartan (Benicar)
- what might happen: can increase the effect and the risk of low blood pressure as a side effect of chlorthalidone and the ARB drug
- beta-blockers:
- drug examples: metoprolol (Lopressor, Toprol XL), carvedilol (Coreg)
- what might happen: can increase the effect and the risk of low blood pressure as a side effect of chlorthalidone and the beta-blocker
- calcium channel blockers (CCBs):
- drug examples: verapamil (Verelan, others), diltiazem (Cardizem, others)
- what might happen: can increase the effect and the risk of low blood pressure as a side effect of chlorthalidone and the CCB drug
- other diuretics:
- drug examples: hydrochlorothiazide (Microzide), furosemide (Lasix)
- what might happen: can increase the effect and the risk of side effects of chlorthalidone and the other diuretics
- antidiabetic drugs:
- drug examples: metformin (Fortamet, Glumetza), insulins such as Tresiba (insulin degludec)
- what might happen: can make the antidiabetic drug more or less effective and may require a dosage adjustment of the antidiabetic drug
- digoxin (Lanoxin):
- what might happen: can increase the risk of side effects of digoxin
- lithium (Lithobid):
- what might happen: can increase the risk of side effects of lithium
- tranylcypromine (Parnate):
- what might happen: can increase the risk of low blood pressure as a side effect of chlorthalidone and tranylcypromine
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When to avoid chlorthalidone
Certain health conditions or other factors could increase some risks with chlorthalidone oral tablet. Because of this, doctors may not prescribe chlorthalidone in these cases. These health conditions or other factors are called contraindications.
Here’s a list of contraindications for chlorthalidone oral tablet:
- Not producing urine (anuria): If you have anuria, chlorthalidone may not work or work as well. Anuria can also raise the risk of a high level of nitrogen waste in your system as a side effect of chlorthalidone.
- Past allergic reaction to chlorthalidone: If you’ve ever had an allergic reaction to chlorthalidone oral tablet, taking it again may cause another allergic reaction.
Before you start taking chlorthalidone, tell your doctor if anything listed above relates to you. They can recommend whether you should take chlorthalidone.
Alcohol and chlorthalidone
Chlorthalidone oral tablet is known to interact with alcohol.
Taking chlorthalidone oral tablet and drinking alcohol may cause or worsen:
If you drink alcohol, talk with your doctor about whether it’s safe to consume it while using chlorthalidone oral tablet.
Other interactions and chlorthalidone
Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether chlorthalidone oral tablet has these interactions.
The information below doesn’t include all other possible interactions with chlorthalidone.
Chlorthalidone and supplements
Before taking chlorthalidone oral tablet, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.
In addition to the interactions discussed below, chlorthalidone may interact with coenzyme Q10 (CoQ10) and fish oil supplements. These supplements are used to support heart health, among other uses.
Taking chlorthalidone and using a CoQ10 or fish oil supplement can increase the risk of low blood pressure as a side effect of chlorthalidone.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Chlorthalidone interactions with herbs
Chlorthalidone oral tablet isn’t known to interact with any herbs. But this doesn’t mean interactions with herbs can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before taking any of these products while using chlorthalidone oral tablet.
Chlorthalidone interactions with vitamins and minerals
Chlorthalidone oral tablet may interact with calcium and vitamin D supplements. These supplements are used to support a healthy level of calcium and vitamin D in your system. Among other uses, this can help support bone health and lower the risk of osteoporosis.
Taking chlorthalidone and using a calcium or vitamin D supplement can increase the risk of hypercalcemia (high level of calcium in the blood) as a side effect from taking chlorthalidone.
Because of this, ask your doctor or pharmacist before taking any of these products while taking chlorthalidone oral tablet.
Chlorthalidone and food
Chlorthalidone oral tablet isn’t known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist about what foods you should avoid while taking chlorthalidone oral tablet.
Chlorthalidone and vaccines
Chlorthalidone oral tablet isn’t known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before receiving any vaccines while using chlorthalidone oral tablet.
Chlorthalidone and lab tests
Chlorthalidone oral tablet may interact with a blood test, which is used to check protein-bound iodine (PBI). Doctors use this test to assess thyroid health and function. Having a low PBI level in your blood can be a sign of problems in thyroid function.
Taking chlorthalidone can cause a low PBI blood level without actually affecting your thyroid function. This means the test may show a low PBI level in your blood, even if your thyroid is functioning as usual.
Because of this, talk with your doctor or pharmacist before having any tests while taking chlorthalidone oral tablet.
Chlorthalidone and cannabis or CBD
Chlorthalidone oral tablet isn’t known to interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But this doesn’t mean interactions can’t happen or won’t be identified later.
As with any drug or supplement, tell your doctor before taking cannabis with chlorthalidone.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Health factors and chlorthalidone
Certain medical conditions or other health factors may increase the risk of interactions with chlorthalidone oral tablet. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking chlorthalidone, tell your doctor about your health history. They’ll determine whether chlorthalidone is right for you.
These health conditions or other factors might interact with chlorthalidone oral tablet:
* Doctors typically won’t prescribe chlorthalidone if you have anuria. To learn more about this warning, check out the “When to avoid” section in this article.
Preventing chlorthalidone interactions
You may be able to help avoid certain interactions with chlorthalidone oral tablet. Before taking this drug, you may want to discuss possible interactions and warnings with your doctor and pharmacist.
Things to consider include:
- Whether you drink alcohol or use cannabis.
- Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
- What to do if you’re prescribed a new drug while using chlorthalidone oral tablet.
Taking chlorthalidone exactly as prescribed can also help prevent interactions.
What to ask your doctor
If you have questions about chlorthalidone and possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Does chlorthalidone have similar interactions as other similar drugs such as hydrochlorothiazide?
- If chlorthalidone interacts with another blood pressure medication I take, should I monitor my blood pressure at home more frequently?
- Are certain other blood pressure medications safer to take with chlorthalidone than others? How severe is the interaction with other blood pressure medications?
- Should I let you know if I make lifestyle changes, such as to my diet or exercise routine?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
