This article describes possible interactions with ceftriaxone injection. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.
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Other drugs and ceftriaxone
The drugs in the list below may interact with ceftriaxone injection. This article does not include all drugs that may interact with ceftriaxone.
Drug classes or drugs that may interact with ceftriaxone injection include:
- certain diuretics (water pills):
- drug examples: furosemide (Lasix), bumetanide (Bumex)
- what might happen: can increase the risk of side effects of ceftriaxone and the diuretic
- birth control pills:
- drug examples: Yasmin 28 (ethinyl estradiol/drospirenone), Lo Loestrin Fe (norethindrone acetate/ethinyl estradiol/ferrous fumarate)
- what might happen: can make birth control pills less effective than usual
- warfarin:
- what might happen: can increase the effect of warfarin
- cyclosporine:
- what might happen: can increase the effect of cyclosporine
- sodium picosulfate/magnesium oxide/anhydrous citric acid (Clenpiq, others):
- what might happen: can make sodium picosulfate/magnesium oxide/anhydrous citric acid less effective than usual
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When to avoid ceftriaxone
Certain health conditions or other factors could increase some risks with ceftriaxone injection. Because of this, doctors may not prescribe ceftriaxone in these cases. These health conditions or other factors are called contraindications.
Here’s a list of ceftriaxone contraindications:
- Premature newborns of certain ages: Premature newborns of certain ages should not receive ceftriaxone injection. The medication may cause serious side effects since their body may not be able to break down the drug.
- Newborns with high bilirubin levels: If your newborn has high bilirubin levels, ceftriaxone injection may worsen their condition.
- Newborns receiving calcium medications through their vein: If your newborn is getting a medication that contains calcium intravenously, administering ceftriaxone injection can cause a solid compound (precipitate) to form in their body.
- Intravenous (IV) administration if used with lidocaine: If your ceftriaxone injection contains lidocaine, you should not receive it intravenously.
- Past allergic reaction to ceftriaxone or another cephalosporin: If you’ve ever had an allergic reaction to ceftriaxone injection or another cephalosporin drug, using it again may cause another allergic reaction.
Before you start using Ceftriaxone, tell your doctor if anything listed above relates to you. They can recommend whether you should use ceftriaxone.
Alcohol and ceftriaxone
Ceftriaxone injection is not known to interact with alcohol.
Talk with your doctor if you have questions about ceftriaxone interactions with alcohol.
Other interactions and ceftriaxone
Interactions can occur with supplements, foods, vaccines, and some lab tests. Below you can learn whether ceftriaxone injection has these interactions.
The information below does not include all other possible interactions with ceftriaxone.
Ceftriaxone and supplements
Before using ceftriaxone injection, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Ceftriaxone interactions with herbs
Ceftriaxone injection is not known to interact with any herbs. But this doesn’t mean interactions with herbs can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before taking any of these products while using ceftriaxone injection.
Ceftriaxone interactions with vitamins
Ceftriaxone injection is not known to interact with any vitamins. But this doesn’t mean interactions with vitamins can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before taking any of these products while using ceftriaxone injection.
Ceftriaxone and food
Ceftriaxone injection is not known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist about ceftriaxone interactions with food.
Ceftriaxone and vaccines
Ceftriaxone injection is not known to interact with any vaccines. But this doesn’t mean interactions with vaccines can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist before receiving any vaccines while using ceftriaxone injection.
Ceftriaxone and lab tests
Ceftriaxone injection may interact with a blood test that checks for hemolytic anemia (a condition in which your body destroys your red blood cells faster than it can make them). Having this test during treatment with ceftriaxone injection may lead to positive results.
Ceftriaxone injection may interact with a blood test that checks for galactosemia (a genetic condition that affects how your body breaks down galactose). Having this test during treatment with ceftriaxone injection may lead to positive results.
Ceftriaxone injection may interact with certain urine tests used to check for glucose. Having this test during treatment with ceftriaxone injection may lead to false-positive results.
Ceftriaxone injection may interact with certain blood glucose monitoring systems. Receiving ceftriaxone injection and using these monitoring systems may lead to falsely lower results.
Because of this, talk with your doctor or pharmacist before having any tests while using ceftriaxone injection.
Ceftriaxone and cannabis or CBD
Ceftriaxone injection is not known to interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But this doesn’t mean interactions can’t happen or won’t be identified later.
As with any drug or supplement, tell your doctor before using cannabis with ceftriaxone.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Health factors and ceftriaxone
Certain medical conditions or other health factors may increase the risk of interactions with ceftriaxone injection. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before receiving Ceftriaxone, tell your doctor about your health history. They’ll determine whether ceftriaxone is right for you.
These health conditions or other factors might interact with ceftriaxone injection:
*For more details about this health condition interaction, see the “When to avoid ceftriaxone” section.
Preventing ceftriaxone interactions
You may be able to help avoid certain interactions with ceftriaxone injection. Before using this drug, you may want to discuss possible interactions with your doctor and pharmacist.
Things to consider include:
- Whether you drink alcohol or use cannabis.
- Other medications and herbs you take, as well as vitamins and supplements. Your doctor or pharmacist can help you fill out a medication list.
- What to do if you’re prescribed a new drug while using ceftriaxone injection.
Using ceftriaxone exactly as prescribed can also help prevent interactions.
What to ask your doctor
If you have questions about ceftriaxone and possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Should I tell you if I start taking another medication or supplement during my ceftriaxone treatment?
- How do interactions of ceftriaxone compare with other cephalosporins?
- Can I still use ceftriaxone if it interacts with a health condition I have?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
