Prempro (generic name is conjugated estrogens and medroxyprogesterone) is used to treat symptoms of menopause such as hot flashes, vaginal dryness and burning, and it is also used to prevent osteoporosis. Prempro prices are comparable to the prices of the brand name alternative called Premphase with an average cost of $180 f0r a 28-day supply. If your insurance does not cover this drug, you can save on your Prempro cost with a free coupon from our site. Just enter your zip code, dosage, and quantity, and then click ‘See My Savings.’ Browse the list of nearby pharmacies that accept our Prempro coupon and their estimated prices for this drug with the Prempro discount. Then, print or download your coupon for Prempro and bring it to one of the pharmacies on the list to save on the cost of your medication. Our coupons do not expire, so you can use your Prempro coupon card to save each time you fill your prescription.

Prempro is used to treat symptoms of menopause such as hot flashes, vaginal dryness, irritation, and burning, and it is also used to prevent osteoporosis.

Prempro is in a class of drugs called hormones. It works by replacing estrogen and progesterone hormones that are normally produced by the body.

The recommended maintenance dose of Prempro for the treatment of postmenopausal symptoms is 0.3 mg-1.5 mg or 0.45 mg-1.5 mg orally once per day.


The recommended dose of Prempro to prevent osteoporosis varies from 0.3 mg-1.5 mg once per day to 0.625 mg-2.5 mg or 0.625-5 mg once per day.

Consult with your doctor for specific dosage and use instructions for Prempro for the treatment of your condition.

Contact your doctor if you experience any of these symptoms and they persist or are severe:


  • back pain

  • depression

  • excess gas in the stomach or intestines

  • weakness


Contact your doctor immediately if you experience any of the following serious symptoms:


  • bloating or swelling of the face, arms, hands, lower legs, or feet

  • blood in the urine

  • blurred vision

  • chest pain

  • clear or bloody discharge from the nipple

  • cough or hoarseness

  • dimpling of the breast skin

  • dizziness

  • rapid, irregular heartbeat or pulse

  • dizziness or lightheadedness

  • feeling of warmth or heat

  • fever or chills
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Use your Optum Perks discount card at pharmacies nationwide, from the large chains to small independent pharmacies.

There is no program or membership to enroll in. Once you receive your card, just show it to your pharmacist and start saving on your prescription medications.

Our card is not insurance, we simply provide discounts on prescriptions. Since pricing is an ongoing negotiation, please bring both your insurance card and Optum Perks coupon to your pharmacist to see which provides a more cost-effective option for you.

No. We merely provide discounts through coupons for prescriptions. Any purchases through Optum Perks will not count toward an insurance deductible.